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Analysis of an engineered organoid model of pancreatic cancer identifies hypoxia as a contributing factor in determining transcriptional subtypes. [PDF]
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Hypoxia Imaging As a Guide for Hypoxia-Modulated and Hypoxia-Activated Therapy
Antioxidants & Redox Signaling, 2022Significance: Oxygen imaging techniques, which can probe the spatiotemporal heterogeneity of tumor oxygenation, could be of significant clinical utility in radiation treatment planning and in evaluating the effectiveness of hypoxia-activated prodrugs. To fulfill these goals, oxygen imaging techniques should be noninvasive, quantitative, and capable of ...
Jeffrey R. Brender +4 more
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Hypoxia. 5. Hypoxia and hematopoiesis
American Journal of Physiology-Cell Physiology, 2011Our understanding of organismal responses to hypoxia has stemmed from studies of erythropoietin regulation by hypoxia that led to the discovery of the master regulator of the hypoxic response, i.e., hypoxia-inducible factor (HIF). This is a transcription factor that is now known to induce the expression of a battery of genes in response to hypoxia ...
Donghoon Yoon +2 more
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Anesthesiology, 1964
During the past three decades or so a vast amount of research has been done in an effort to discover a procedure, or find some agent, which would increase man's tolerance to hypoxia. For the most part, early studies were concerned with attempts to raise the ceiling of aircraft pilots, that is, enable them to withstand a more severe degree of hypoxia ...
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During the past three decades or so a vast amount of research has been done in an effort to discover a procedure, or find some agent, which would increase man's tolerance to hypoxia. For the most part, early studies were concerned with attempts to raise the ceiling of aircraft pilots, that is, enable them to withstand a more severe degree of hypoxia ...
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Journal of Applied Physiology, 2021
The word “hypoxia” has recently come to the attention of the general public on two occasions, the Nobel Prize in Medicine or Physiology in 2019 and the recent COVID-19 pandemic. In the academic environment, hypoxia is a current topic of research in biology, physiology, and medicine: in October 2020, there were more than 150,000 occurrences of “hypoxia”
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The word “hypoxia” has recently come to the attention of the general public on two occasions, the Nobel Prize in Medicine or Physiology in 2019 and the recent COVID-19 pandemic. In the academic environment, hypoxia is a current topic of research in biology, physiology, and medicine: in October 2020, there were more than 150,000 occurrences of “hypoxia”
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The British Journal of Radiology, 1970
The importance of hypoxia in radiobiology and radiotherapy continues to occupy much space in this journal (Littbrand and Revesz, 1969; Berry, Hall and Cavanagh, 1970). In spite of the excellent review by Boag (1969) we feel the pitfalls, namely: (a) variation in height of medium with its subsequent effect on oxygen diffusion and cell numbers; (b) the ...
J. L. Moore, C. W. Smith
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The importance of hypoxia in radiobiology and radiotherapy continues to occupy much space in this journal (Littbrand and Revesz, 1969; Berry, Hall and Cavanagh, 1970). In spite of the excellent review by Boag (1969) we feel the pitfalls, namely: (a) variation in height of medium with its subsequent effect on oxygen diffusion and cell numbers; (b) the ...
J. L. Moore, C. W. Smith
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Journal of Insect Physiology, 2001
Insects exhibit a remarkable array of adaptations that allow them to handle more or less severe hypoxia associated with numerous aquatic and terrestrial habitats. We consider these habitats and then discuss physiological, behavioral and morphological mechanisms that facilitate insect life under oxygen deprivation.
W. Wyatt Hoback, David Stanley
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Insects exhibit a remarkable array of adaptations that allow them to handle more or less severe hypoxia associated with numerous aquatic and terrestrial habitats. We consider these habitats and then discuss physiological, behavioral and morphological mechanisms that facilitate insect life under oxygen deprivation.
W. Wyatt Hoback, David Stanley
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, 2019 A hypoxic environment can be defined as a region of the body or the whole body that is deprived of oxygen. Hypoxia is a feature of many diseases, such as cardiovascular disease, tissue trauma, stroke, and solid cancers. A loss of oxygen supply usually results in cell death; however, when cells gradually become hypoxic, they may survive and continue to ...
Michael Ladomery, Elizabeth Bowler
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International Urology and Nephrology, 2013
This review mainly focuses on our understanding of spermatogenesis in physiological and pathological hypoxic condition. Real hypoxia is closely related to vascular changes and an increase in testicular temperature. Both induce a reduction in sperm count and can be related to the increase in germ cell apoptosis.
Ljubinka Jankovic Velickovic +1 more
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This review mainly focuses on our understanding of spermatogenesis in physiological and pathological hypoxic condition. Real hypoxia is closely related to vascular changes and an increase in testicular temperature. Both induce a reduction in sperm count and can be related to the increase in germ cell apoptosis.
Ljubinka Jankovic Velickovic +1 more
openaire +3 more sources