Results 271 to 280 of about 1,114,410 (399)

Electrographic reflections of cerebral hypoxia [PDF]

, 1961
William C. Gibson
openalex   +1 more source

The Nuclear Localization of ACLY Guards Early Embryo Development Through Recruiting P300 and HAT1 to Promote Histone Acetylation and Transcription

Advanced Science, EarlyView.
ACLY is vital for early embryo development. IGF‐1 activates AKT to phosphorylate ACLY, driving its nuclear localization and recruitment of HATs (P300/HAT1), boosting acetyl‐CoA production and histone acetylation for transcriptional activation. Conversely, ACLY deficiency (via knockdown, knockout, or AKT inhibition) reduces nuclear acetyl‐CoA, disrupts ...
Yerong Ma, Yingyi Zhang, Weijie Yang, Xiaomei Tong, Siya Liu, Yan Zhou, Mengjia Qiu, Huifang Jiang, Zhanhong Hu, Peipei Ren, Yan Rong, Mengru Lai, Jiamin Jin, Fei Huang, Liujian Ouyang, Feng Zhou, Heng‐Yu Fan, Yin‐Li Zhang, Songying Zhang   +18 more
wiley   +1 more source

Comprehensive analysis of SQOR involvement in ferroptosis resistance of pancreatic ductal adenocarcinoma in hypoxic environments. [PDF]

Front Immunol
Lin Q, Guan S, Peng M, Zhang K, Zhang H, Mo T, Yu H.   +6 more
europepmc   +1 more source

THE EFFECT OF HYPOXIA ON ELECTRICAL ACTIVITY OF THE VISUAL SYSTEM IN CATS

, 1966
Leo C. Massopust, L.R. Wolin, H. W. BARNES   +2 more
openalex   +2 more sources

HYPOXIA [PDF]

, 1968

openalex   +1 more source

Neuraminidase 1 Exacerbated Glycolytic Dysregulation and Cardiotoxicity by Destabilizing SIRT1 through Interactions with NRF2 and HIF1α

Advanced Science, EarlyView.
NEU1, a key regulator of glycolysis, is markedly upregulated following DOX treatment. This upregulation is attributed to HIF1α’s transcriptional repression, requiring intricate interactions with NRF2. Increased NEU1 facilitates SIRT1 lysosomal degradation, contributing to aberrant glycolytic phenotype and cardiac damage.
Ting Gao, Yufeng Tang, Tao Zeng, Jie Wang, Xiaohui Zhang, Qingbo Liu, Xun Guan, Xinyu Tang, Guangping Lu, Jiahao Li, Mingrui Liu, Dongmei Zhang, Sixuan Lv, Junlian Gu   +13 more
wiley   +1 more source

Exosomal PD-L1 derived from hypoxia nasopharyngeal carcinoma cell exacerbates CD8⁺ T cell suppression by promoting PD-L1 upregulation in macrophages. [PDF]

Cancer Immunol Immunother
Yuan X, Liu X, Jiang D, Zheng Z, Ma X, Wu S, Li X, Lu J, Fu M.   +8 more
europepmc   +1 more source

MYC Binding Near Transcriptional End Sites Regulates Basal Gene Expression, Read‐Through Transcription, and Intragenic Contacts

Advanced Science, EarlyView.
MYC is a transcription factor (TF) that binds DNA near transcriptional start sites (TSSs) and within enhancer elements. Here, unappreciated sites of MYC binding in the vicinity of transcriptional end sites (TESs) of many genes in multiple cell types in association with numerous other TFs are described previously.
Huabo Wang, Bingwei Ma, Taylor Stevens, Jessica Knapp, Jie Lu, Edward V. Prochownik   +5 more
wiley   +1 more source

Improving cellular fitness of human stem cell-derived islets under hypoxia. [PDF]

Nat Commun
Wang X, Brielle S, Kenty-Ryu J, Korover N, Bavli D, Pop R, Melton DA.   +6 more
europepmc   +1 more source

Role of the Liver in Enteral Insufflation of Oxygen during Hypoxia in Infant Rats [PDF]

, 1962
B. Korecký, O Poupa
openalex   +1 more source