Results 281 to 290 of about 1,114,410 (399)

Unraveling Neurodevelopment: Synergistic Effects of Intrinsic Genetic Programs and Extrinsic Environmental Cues

Advanced Science, EarlyView.
Overview of the regulation of intrinsic and extrinsic signals during neurodevelopment. Intrinsic genetic signals from NSCs, in conjunction with cues from microglia and blood vessels, collaboratively regulate the proliferation of NSCs, their fate determination, synaptogenesis, synaptic pruning, neuronal survival, and death, as well as communication ...
Yanyan Wang, Shukui Zhang, Huiyang Jia, Fen Ji, Jianwei Jiao   +4 more
wiley   +1 more source

Inhibition of MCP1 (CCL2) Enhances Antitumor Activity of NK Cells Against HCC Cells Under Hypoxia. [PDF]

Int J Mol Sci
Lee HH, Kim J, Park E, Kang H, Cho H.
europepmc   +1 more source

Metal–Organic Frameworks: Unlocking New Frontiers in Cardiovascular Diagnosis and Therapy

Advanced Science, EarlyView.
Metal–organic frameworks (MOFs), are composed of metal ions and bridging organic ligands, are recognized as an excellent platform for host‐gust chemistry. Its rich structural composition, modifiable sites, and multilevel pore distribution can provide delivery and release of signaling molecules, probes, and therapeutic drugs, which exhibit great medical
Qilu Wu, Yuxiao Feng, Mathilde Lepoitevin, Meng Yu, Christian Serre, Jun Ge, Yuan Huang   +6 more
wiley   +1 more source

P4HA1 mediates hypoxia-induced invasion in human pancreatic cancer organoids. [PDF]

Cancer Res Commun
Navarro-Serer B, Wissler MF, Glover BK, Lerner MG, Oza HH, Wang V, Knutsdottir H, Shojaeian F, Noller K, Baskaran SG, Hughes S, Weaver AM, Wilentz D, Olayemi O, Bader JS, Fertig EJ, Gilkes DM, Wood LD.   +17 more
europepmc   +1 more source

COPS5 Triggers Ferroptosis Defense by Stabilizing MK2 in Hepatocellular Carcinoma

Advanced Science, EarlyView.
COPS5, which is overexpressed in HCC in an amplification‐ and ATF4‐dependent manner, stabilizes MK2 through deubiquitination and, in turn, induces HSPB1 activation, protecting HCC cells from ferroptosis and thus promoting sorafenib resistance and tumor progression. Abstract Sorafenib, which is proven to serve as a potent ferroptosis inducer, is used as
Ai‐Ling Luo, Wen‐Ying Zheng, Qiong Zhang, Yan Yuan, Mei‐Qi Li, Kai Du, An‐Ran Gao, Li‐Jun Pei, Jie Xie, Wen‐Hao Chen, Long Zhang, Xiu‐Zhu Guo, Xiao‐Ran Yang, Chao Zeng, Guo‐Hua Yang, Min Deng   +15 more
wiley   +1 more source

THE EFFECT OF MATERNAL HYPOXIA ON THE HEART RATE OF THE FOETUS IN UTERO

, 1965
A. Howard John
openalex   +1 more source

Collaborative Duality of CircGLIS3(2) RNA and Protein in human Wound Repair

Advanced Science, EarlyView.
CircGLIS3(2), a circRNA transiently upregulated in dermal fibroblasts during acute wound healing, is induced by IL‐1α and TGF‐β. Its RNA activates fibroblasts into matrix‐secreting cells, while its encoded protein enhances proliferation. The RNA stabilizes PCOLCE, and the protein interacts with BTF3, collectively accelerating wound repair. Abstract The
Guanglin Niu, Maria A. Toma, Jennifer Geara, Xiaowei Bian, Yongjian Chen, Lihua Luo, Qizhang Wang, Yunting Xiao, Manika Vij, Minna Piipponen, Zhuang Liu, Sho Oasa, Letian Zhang, Dörte Schlesinger, Ákos Végvári, Dongqing Li, Aoxue Wang, Vladana Vukojević, Simon J Elsässer, Pehr Sommar, Ning Xu Landén   +20 more
wiley   +1 more source

Neovascular pruning by IDO1 inhibitors can potentiate immunogenic cytotoxicity of ischemia-targeted agents to synergistically enhance anti-PD-1 responsiveness. [PDF]

J Immunother Cancer
Shen SC, Dey S, DuHadaway JB, Sutanto-Ward E, Hampton MT, Kozlov SV, Prendergast GC, Muller AJ.   +7 more
europepmc   +1 more source

Advances in Hypoxia-Inducible Factor Biology.

Cell Metabolism, 2017
H. Choudhry, A. Harris
semanticscholar   +1 more source

Ruthenium Single‐Atom Nanozyme Driven Sonosensitizer with Oxygen Vacancies Enhances Electron–Hole Separation Efficacy and Remodels Tumor Microenvironment for Sonodynamic‐Amplified Ferroptosis

Advanced Science, EarlyView.
An atomic‐level engineered ruthenium single‐atom nanozyme is fabricated that features sufficient oxygen vacancies and electron and hole separation efficiency, which enhances response to the sono‐suppressive tumor microenvironment and induces tumor ferroptosis.
Yang Zhu, Dengliang Wang, Chengzhong Du, Tiantian Wu, Penghui Wei, Hongjia Zheng, Guanting Li, ShunZhe Zheng, Lichao Su, Lingjun Yan, Yongrui Hu, Huimin Wang, Lisen Lin, Chenyu Ding, Xiaoyuan Chen   +14 more
wiley   +1 more source