Results 51 to 60 of about 956,013 (356)

Beyond Pharmacology: The Biological Mechanisms of Remote Ischemic Conditioning in Cerebrovascular Disease

Biomolecules
Cerebrovascular diseases (CVDs), comprising predominantly ischemic stroke and chronic cerebral hypoperfusion (CCH), are a significant threat to global health, often leading to disability and mortality.
Linhui Qin, Fang Tong, Sijie Li, Changhong Ren   +3 more
doaj   +1 more source

Effects of Normobaric Hypoxia on Oculomotor Dynamics of Aviator Students during a Simulated Flight Task [PDF]

, 2020
Hypoxia occurs when the body\u27s tissues are unable to obtain adequate oxygen supply and is the primary environmental factor present when pilots are exposed to increasing altitude levels.
Blackley, Anna, de Moors, Moroni, Deshner, Austin, Ehrlich, Kaela, Engberg, Josh, Hornsby, Jared, Hu, Theodore, Jankovic, Maja, McCarty, Abby, Morrison, Mitchell, Rider, Carl Wesley, Walsh, Brian   +11 more
core   +1 more source

Hypoxia activates IKK-NF-κB and the immune response in Drosophila melanogaster [PDF]

, 2014
Hypoxia, or low oxygen availability, is an important physiological and pathological stimulus for multicellular organisms. Molecularly, hypoxia activates a transcriptional programme directed at restoration of oxygen homoeostasis and cellular survival.
An, Azad, Bartels, Bonello, Centanin, Culver, Cummins, Cummins, Daniel Bandarra, Dekanty, Fandrey, Fu, Glittenberg, H. Arno Muller, Harhaj, Hetru, Jiang, John Biddlestone, Jono, Kenneth, Kounatidis, Lando, Lavista-Llanos, Liu, Lu, Massoumi, Melvin, Moniz, Perkins, Perkins, Ratcliffe, Rius, Rocha, Romero, Ruland, Scholz, Semenza, Sharon Mudie, Silke, Silverman, Silverman, Sonia Rocha, Sonnenfeld, Tornatore, Tsichritzis, van Uden, van Uden, Walmsley, Xue   +48 more
core   +5 more sources

Modeling Thoracic Aortic Dissection Using Patient-Specific iPSCs Reveals VSMC Dysfunction and Extracellular Matrix Dysregulation

Stem Cells International
Thoracic aortic dissection (TAD) is a life-threatening condition characterized by medial degeneration and vascular smooth muscle cell (VSMC) dysfunction, with no effective medical therapy currently available. The underlying pathological mechanisms of TAD
Peifeng Jin, Yubin Xu, Sixian Wang, Lu Ding, Yuhao Chen, Miqi Zhou, Xiufang Chen, Xiaofang Fan, Yongsheng Gong, Ming Li, Yongyu Wang   +10 more
doaj   +1 more source

Progressive Hypoxia-on-a-chip: An In Vitro Oxygen Gradient Model for Capturing the Effects of Hypoxia on Primary Hepatocytes in Health and Disease

, 2019
Oxygen is vital to the function of all tissues including the liver and lack of oxygen, that is, hypoxia can result in both acute and chronic injuries to the liver in vivo and ex vivo.
Bulutoglu, Beyza, Eo, Jinsu, Kang, Young Bok Abraham, Usta, O. Berk, Yarmush, Martin L.   +4 more
core   +1 more source

Hypoxia Upregulates Estrogen Receptor β in Pulmonary Artery Endothelial Cells in a HIF-1α-Dependent Manner [PDF]

, 2018
17β-Estradiol (E2) attenuates hypoxia-induced pulmonary hypertension (HPH) through estrogen receptor (ER)-dependent effects, including inhibition of hypoxia-induced endothelial cell proliferation; however, the mechanisms responsible for this remain ...
Albrecht, Marjorie, Frump, Andrea L., Lahm, Tim, Petrache, Irina, Selej, Mona, Wood, Jordan A., Yakubov, Bakhtiyor   +6 more
core   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Verteporfin Mitigates Isoproterenol-Induced Myocardial Hypertrophy by Attenuating IL-6/STAT3 in Cardiac Fibroblasts

Cardiovascular Therapeutics
Conclusions: Verteporfin protects the heart against ISO-induced myocardial hypertrophy by regulating IL-6/STAT3 in cardiac fibroblasts.
Sunpeng Sheng, Lu Ding, Jinbiao Lai, Zelei Ye, Ru Zhao, Shijia Chen, Jianshe Ma, Junming Fan, Peifeng Jin   +8 more
doaj   +1 more source

Weight Loss and Fat Metabolism during Multi-Day High-Altitude Sojourns: A Hypothesis Based on Adipocyte Signaling

Life, 2022
Several publications and random observations have reported weight loss in high-altitude sojourners of both sexes. This could be a result of multiple adaptations, which hypoxia and mountaineering provoke on a cellular and organic level.
Stephan Pramsohler, Martin Burtscher, Linda Rausch, Nikolaus C. Netzer   +3 more
doaj   +1 more source

Hypoxia Produces Pro-arrhythmic Late Sodium Current in Cardiac Myocytes by SUMOylation of NaV1.5 Channels. [PDF]

, 2020
Acute cardiac hypoxia produces life-threatening elevations in late sodium current (ILATE) in the human heart. Here, we show the underlying mechanism: hypoxia induces rapid SUMOylation of NaV1.5 channels so they reopen when normally inactive, late in the ...
Dai, Hui, Goldstein, Steve AN, Plant, Leigh D, Romero, Jesus, Xiong, Dazhi   +4 more
core