Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects.
Journal of the National Cancer Institute, 2001 Tissue hypoxia results from an inadequate supply of oxygen (O(2)) that compromises biologic functions. Evidence from experimental and clinical studies increasingly points to a fundamental role for hypoxia in solid tumors. Hypoxia in tumors is primarily a
M. Höckel, P. Vaupel
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Tumor Hypoxia as a Barrier in Cancer Therapy: Why Levels Matter
Cancers, 2021 Simple Summary Hypoxia is a common feature of solid tumors and associated with poor outcome in most cancer types and treatment modalities, including radiotherapy, chemotherapy, surgery and, most likely, immunotherapy.
T. Hompland, C. Fjeldbo, H. Lyng
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Editorial for Life Special Issue Book Cellular and Functional Response to Hypoxia
Life, 2022 Hypoxia is a current research topic in biology, physiology, and medicine [...]
Jean-Paul Richalet
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Effect of acute severe hypoxia on peripheral fatigue and endurance capacity in healthy humans [PDF]
, 2007 Effect of acute severe hypoxia on peripheral fatigue and endurance capacity in healthy humans. Am J Physiol Regul Integr Comp Physiol 292: R598–R606, 2007. First published September 7, 2006; doi:10.1152/ajpregu.00269.2006.—We hypothesized that severe
Amann, M +5 more
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Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
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Metabolic and hypoxic adaptation to anti‐angiogenic therapy: a target for induced essentiality
EMBO Molecular Medicine, 2015 Anti‐angiogenic therapy has increased the progression‐free survival of many cancer patients but has had little effect on overall survival, even in colon cancer (average 6–8 weeks) due to resistance.
Alan McIntyre, Adrian L Harris
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Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
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MiR675-5p acts on HIF-1α to sustain hypoxic responses: A new therapeutic strategy for glioma [PDF]
, 2016 Hypoxia is a common feature in solid tumours. In glioma, it is considered the major driving force for tumour angiogenesis and correlates with enhanced resistance to conventional therapies, increased invasiveness and a poor prognosis for patients. Here we
Alessandro, Riccardo +10 more
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Hypoxia-Induced Epithelial-Mesenchymal Transition in Cancers: HIF-1α and Beyond
Frontiers in Oncology, 2020 Metastasis is the main cause of cancer-related mortality. Although the actual process of metastasis remains largely elusive, epithelial-mesenchymal transition (EMT) has been considered as a major event in metastasis.
S. Tam, V. Wu, H. Law
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Circulating histones as clinical biomarkers in critically ill conditions
FEBS Letters, EarlyView.Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez +17 more
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