Results 71 to 80 of about 1,114,410 (399)
Stem Cell Research, 2020 A human induced pluripotent stem cell (hiPSC) line (WMUi001-A) was generated from the aortic tissue of a 47-year-old donor with aortic dissection and normal blood pressure.
Peifeng Jin +14 more
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STAR Protocols, 2022 Summary: In human pluripotent stem cells (hPSCs), traditional approaches for gene overexpression have low efficiency and are often laborious. Here, we provide a relatively simple protocol for gene overexpression with the Dox-inducible PiggyBac transposon
Jiwen Yang, Minjie Hu, Yongyu Wang
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Journal of Molecular and Cellular Cardiology, 1979 Abstract During hypoxia peak developed tension falls rapidly, resting tension inceeases slowly and recovery is incomplete if the hypoxia is sufficiently prolonged for resting tension to become greatly elevated. We propose that the initial fall of peak developed tension is due to a failure of excitation-contraction coupling at a time when high energy ...
Winifred G. Nayler +2 more
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Tumor Hypoxia as a Barrier in Cancer Therapy: Why Levels Matter
Cancers, 2021 Simple Summary Hypoxia is a common feature of solid tumors and associated with poor outcome in most cancer types and treatment modalities, including radiotherapy, chemotherapy, surgery and, most likely, immunotherapy.
T. Hompland, C. Fjeldbo, H. Lyng
semanticscholar +1 more source
BiomoleculesCerebrovascular diseases (CVDs), comprising predominantly ischemic stroke and chronic cerebral hypoperfusion (CCH), are a significant threat to global health, often leading to disability and mortality.
Linhui Qin +3 more
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Open Life Sciences, 2023 Curcumin is the most abundant derivative of turmeric rhizome. Although studies have proved that curcumin could inhibit the growth of tumors, its specific molecular mechanism has not yet been fully elucidated.
Wang Xiaoping +4 more
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Collagens Regulating Adipose Tissue Formation and Functions
Biomedicines, 2023 The globally increasing prevalence of obesity is associated with the development of metabolic diseases such as type 2 diabetes, dyslipidemia, and fatty liver.
Iida Jääskeläinen +6 more
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Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects.
Journal of the National Cancer Institute, 2001 Tissue hypoxia results from an inadequate supply of oxygen (O(2)) that compromises biologic functions. Evidence from experimental and clinical studies increasingly points to a fundamental role for hypoxia in solid tumors. Hypoxia in tumors is primarily a
M. Höckel, P. Vaupel
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MiR675-5p acts on HIF-1α to sustain hypoxic responses: A new therapeutic strategy for glioma [PDF]
, 2016 Hypoxia is a common feature in solid tumours. In glioma, it is considered the major driving force for tumour angiogenesis and correlates with enhanced resistance to conventional therapies, increased invasiveness and a poor prognosis for patients. Here we
Alessandro, Riccardo +10 more
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Hypoxia. 3. Hypoxia and neurotransmitter synthesis [PDF]
American Journal of Physiology-Cell Physiology, 2011 Central and peripheral neurons as well as neuroendocrine cells express a variety of neurotransmitters/modulators that play critical roles in regulation of physiological systems. The synthesis of several neurotransmitters/modulators is regulated by O2-requiring rate-limiting enzymes.
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