Results 111 to 120 of about 3,831,267 (331)

Involvement of E3 Ligases and Deubiquitinases in the Control of HIF-α Subunit Abundance

Cells, 2019
The ubiquitin and hypoxia-inducible factor (HIF) pathways are cellular processes involved in the regulation of a variety of cellular functions. Enzymes called ubiquitin E3 ligases perform protein ubiquitylation.
Kateryna Kubaichuk, Thomas Kietzmann
doaj   +1 more source

Profiling the effect of low frequency mechanical vibration on the metabolic and oxidative stress responses of A431 carcinoma

FEBS Open Bio, EarlyView.
20 Hz mechanical vibration induced A431 cancer cells' apoptosis without such effect on other healthy cell lines of L929 and C2C12. Lowered glucose consumption is observed specifically in A431. The expressions of ROS, HMGB1, and HSP1 levels initially increase and subsequently decrease in the cancer cell line, as opposed to L929 and C2C12, which ...
Wresti L. Anggayasti, Chikahiro Imashiro, Takashi Morikura, Shogo Miyata, Akira Funahashi, Kenjiro Takemura   +5 more
wiley   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment

Advanced Biology, EarlyView.
The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li, Sepehr Akhtarkhavari, Sumeng Qi, Jiawei Fan, Tu‐Yung Chang, Yao‐An Shen, JinMing Yang, Barbara S. Slusher, Ie‐Ming Shih, Stephanie Gaillard, Tian‐Li Wang   +10 more
wiley   +1 more source

The effect of hypoxia onDaphnia magnaperformance and its associated microbial and bacterioplankton community: a scope for Genotype x Microbial community interactions upon environmental stress ? [PDF]

, 2023
Manon Coone, Isabel Vanoverberghe, Shira Houwenhuyse, Chris Verslype, Ellen Decaestecker   +4 more
openalex   +1 more source

Distinct Tumor Microenvironment at Tumor Edge as a Result of Astrocyte Activation Is Associated With Therapeutic Resistance for Brain Tumor

Frontiers in Oncology, 2019
Tumor vasculatures and hypoxia are critical tumor micro-environmental factors associated with tumor response to the therapy and heterogeneous in both time- and location-dependent manner.
Chiu-Min Lin, Ching-Fang Yu, Ching-Fang Yu, Hsueh-Ya Huang, Hsueh-Ya Huang, Fang-Hsin Chen, Fang-Hsin Chen, Fang-Hsin Chen, Ji-Hong Hong, Ji-Hong Hong, Ji-Hong Hong, Chi-Shiun Chiang, Chi-Shiun Chiang, Chi-Shiun Chiang   +13 more
doaj   +1 more source

Novel Biologically Active Glass Fiber Functionalized Using Magnesium Phosphate Cement Promotes Bone and Vascular Regeneration

Advanced Biology, EarlyView.
In this study, a new type of bioactive glass fiber ‐based composite magnesium phosphate bone cement is prepared and verified that its mechanical strength and biological properties. In addition, the cement may have played a biologically active role in the Notch and HIF signaling pathways.
Yuzheng Lu, Yanbo Shan, Yingjie Xiong, Jianting Ye, Yanbin Wu, Jipeng Song, Yao Zhang, Wancheng Lin, Haoye Meng, Wenjing Xu, Jiang Peng, Qiang Lu, Lixiang Ding   +12 more
wiley   +1 more source

Metabolic adaptation of the intertidal worm Sipunculus nudus to functional and environmental hypoxia

Marine Biology, 1984
The scope of anaerobic metabolism of Sipunculus nudus L. was assessed from the maximal activities of some enzymes of the intermediary metabolism and from the concentration of some metabolites accumulated during enhanced muscular activity and during prolonged experimental hypoxia.
Pörtner, Hans-Otto, Kreutzer, U., Siegmund, B., Heisler, N., Grieshaber, M. K.   +4 more
openaire   +3 more sources

Video classification of hypoxic habitats and benthic communities in two productive freshwater embayments

Ecological Indicators
Ongoing anthropogenic eutrophication and warming temperatures are expected to increase the extent and severity of hypoxia globally. Monitoring hypoxia has traditionally relied on costly surveys or sensor networks.
Lyubov E. Burlakova, Alexander Y. Karatayev, Susan E. Daniel, Justin R. Meyer, Tomas O. Höök, Sarah Lawhun, Kelly L. Bowen, Warren J.S. Currie, Paris D. Collingsworth   +8 more
doaj  

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source