Results 151 to 160 of about 3,831,267 (331)
TUMOR HYPOXIA DIAGNOSIS USING DEEP CNN LEARNING STRATEGY A THERANOSTIC PHARMACOGENOMIC APPROACH
International Journal of Prognostics and Health Management, 2019 Tumor hypoxia results in most of the anticancer drugs becoming ineffective. However, due to lack of proper signaling in the hypoxic micro environment, the condition cannot be detected in advance, leading into unnecessary delay in the diagnosis and ...
Vaisali B +3 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.This review highlights recent progress in nanocarriers targeting pattern recognition receptors (PRRs), including Toll‐like and NOD‐like receptors, for enhancing the treatment of bacterial sepsis and related complications. These nanomedicines deliver antibiotics and anti‐inflammatory agents while modulating immune responses.
Eman A. Ismail +3 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Extracellular vesicles (EVs) are pivotal mediators of intercellular communication and disease, yet the fundamental mechanisms controlling their biogenesis and cargo selection remain unclear. This limitation hinders their diagnostic utility and therapeutic development.
Luís Carvalho Ferraz +2 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.This study presents a multiphasic bile duct construct composed of biocompatible materials and cells, featuring an inner layer that supports biliary epithelium growth, a middle layer providing mechanical strength, and an outer cell‐permissive layer designed to support future in vivo integration.
Mattia Pasqua +9 more
wiley +1 more source
Bioenergetics of adaptation to the environmental hypoxia of high altitude at rest and exercise
The FASEB Journal, 2008 The effect of hypoxia on the mechanism of energy transduction has been studied by determining the rates of O2 uptake and energy generation in both humans and guinea‐pig mitochondria under resting and active metabolic conditions. The following findings were made. 1) The O2 level required for half maximal rates of ATP syntesis (Km for O2)is higher than 0.
openaire +1 more source
Tumor Microenvironment‐responsive Nanocatalyst for Targeted Chemodynamic Cancer Therapy
Advanced Healthcare Materials, EarlyView.An Tumor microenvironment‐responsive nanocatalyst system composed of PLGA‐encapsulated Ca–Fe peroxide and polyarginine enables sustainable Fenton reaction in tumors. Low levels of H2O2 (50–100 µm) initiate the nanoparticle degradation, while polyarginine‐derived nitric oxide accelerates Fe3+ reduction, leading to self‐amplifying •OH generation for ...
Jun Ma, Jingjing Qiu, Shiren Wang
wiley +1 more source
Ultra‐Tiny Gelatin Nanoparticles‐Assisted 3D Stem Cell Spheroids for Engineering Tissue Regeneration
Advanced Healthcare Materials, EarlyView.GNPs effectively guide the formation of structurally compact and functionally enhanced stem cell spheroids. This GNP‐assisted 3D culture system improves cell–cell and cell‐ECM interactions, leading to superior viability and complexity. Time‐dependent regenerative potential is demonstrated in both bone and skin defects, positioning GNP‐spheroids as a ...
Dream Kim +7 more
wiley +1 more source