Results 41 to 50 of about 9,128 (213)

Antenatal allopurinol for reduction of birth asphyxia induced brain damage (ALLO-Trial); a randomized double blind placebo controlled multicenter study

BMC Pregnancy and Childbirth, 2010
Background Hypoxic-ischaemic encephalopathy is associated with development of cerebral palsy and cognitive disability later in life and is therefore one of the fundamental problems in perinatal medicine. The xanthine-oxidase inhibitor allopurinol reduces
von Lindern Jeannette, van Meir Claudia A, Bakker Saskia CMJER, Huisjes Anjoke JM, van Elburg Ruurd M, Wouters Maurice GAJ, Gavilanes AW Danilo, Willekes Christine, Oetomo Sidarto, Porath Martina M, Bos Arie F, van Pampus Maria G, Rijken Monique, Bloemenkamp Kitty WM, de Haan Timo R, Oudijk Martijn A, Torrance Helen L, Rademaker Carin MA, Benders Manon JNL, Kaandorp Joepe J, Boon Janine, de Boer Inge P, Rijnders Robbert JP, Jacobs Corrie JWFM, Uiterwaal Cuno SPM, Mol Ben Willem J, Visser Gerard HA, van Bel Frank, Derks Jan B   +28 more
doaj   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

Mimickers of hypoxic-ischaemic brain injury in term neonates: What the radiologist should know

South African Journal of Radiology
Patterns of neonatal hypoxic-ischaemic brain injury (HIBI) are fairly well known. There are, however, other diagnoses with imaging patterns that may mimic HIBI.
Shalendra K. Misser, Moherndran Archary
doaj   +1 more source

Research progress on biomarkers of traumatic brain injury

Animal Models and Experimental Medicine, EarlyView.
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen, Si Cheng, Shuyi Chen, Mengyue Wang, Tangying Li, Weicheng Xu, Yifan Zhang, Ping Yuan, Lei Shi   +8 more
wiley   +1 more source

Biochemical profile of term neonates with perinatal asphyxia and their correlation with severity of asphyxia

Journal of Family Medicine and Primary Care
Background: Birth asphyxia is a major cause of neonatal mortality and neurological morbidity. This study was aimed to determine biochemical (sodium, potassium, and calcium) abnormalities and their correlation across different severities of perinatal ...
Sachin V. Bhoye, Neha D. Bhongale, Rohit M. Thorat, Poonam A. Wade   +3 more
doaj   +1 more source

Clinical and Laboratory Barriers to the Timely Diagnosis of Sulphite Oxidase Deficiency

Proceedings of Singapore Healthcare, 2010
Isolated sulphite oxidase deficiency (SOD) is a rare genetic neurometabolic disorder characterised by intractable seizures and progressive severe neurological dysfunction.
Chew Thye Choong MBBS, MMED (Paed), Claire Hart MSc Clinical Biochemistry, FRCPath, Ee Shien Tan MBBS, MMED (Paed), Denise Li Meng Goh MBBS, MMED (Paed)   +3 more
doaj   +1 more source

Low diagnostic yield of presurgical genetic testing in adult patients with epilepsy

Epilepsia, EarlyView.
Abstract Objective To determine the diagnostic yield of genetic testing in patients undergoing presurgical evaluation for epilepsy. Methods We conducted a cohort study including 115 adult patients who underwent presurgical evaluation in the Calgary Epilepsy Program between 2019 and 2023 and who had undergone research exome sequencing.
Clara Jünemann, Amanda Stuart, Navprabhjot Kaur, Samuel Wiebe, Nathalie Jette, Shaily Singh, Felippe Borlot, Susanne Knake, The Calgary Comprehensive Epilepsy Program Collaborators, Paolo Federico, Colin Josephson, William Murphy, Andrea Salmon, Guillermo Delgado Garcia, Walter Hader, Ping Yee Billie Au, Karl Martin Klein   +16 more
wiley   +1 more source

Perinatal hypoxic-ischaemic encephalopathy: Clinical and etiopathogenetic classification

, 2003
Hypoxic-ischaemic encephalopathy is one of the clinical expressions of hypoxic-ischaemic damage in which concomitant hypoxia and ischaemia are responsible for the death of the foetus or neonate, or result in organ impairment with possible long-term ...
Ramenghi L. A., Mosca F., Bassi L., Fumagalli M.   +3 more
core   +1 more source

Diagnosis and management guidelines for infantile epileptic spasms syndrome around the world: A scoping review and comparative study of international approaches

Epilepsia, EarlyView.
Abstract Objective Infantile epileptic spasms syndrome (IESS) is an epileptic encephalopathy requiring rapid diagnosis and treatment to optimize neurodevelopmental outcomes. Although multiple national and regional guidelines exist, recommendations vary.
Gozde Erdemir, Chethan K. Rao, Anne Francine Pino, Christina Briscoe, Debopam Samanta, Jo M. Wilmshurst, Sonal Bhatia, Jessica L. Carpenter, Christina Hoei‐Hansen, Puneet Jain, Tommy Stodberg, Robyn Whitney, Ryuki Matsuura, Karina Rosso Astorga, Keryma Acevedo Gallinato, Pratibha Singhi, Aristides Hadijinicolaou, Gia Melikishvili, Patricia Smeyers, Nicola Specchio, Stéphane Auvin, Pediatric Epilepsy Research Consortium Infantile Spasm Work Group and International Committee   +21 more
wiley   +1 more source

THERAPEUTIC HYPOTHERMIA (TH) IN NEONATAL HYPOXIC ISCHAEMIC ENCEPHALOPATHY (HIE)

Pakistan Armed Forces Medical Journal, 2018
Therapeutic hypothermia is considered as a standard of care in the treatment of moderate to severe hypoxic ischaemic encephalopathy in neonates ≥36 weeks of gestation and is considered safe and effective.
Irfan Ahmed
doaj