Results 1 to 10 of about 4,093 (154)

An epigenetic perspective on neonatal encephalopathy with suspected hypoxic ischaemic encephalopathy [PDF]

Clinical Epigenetics
Neonatal encephalopathy with suspected hypoxic ischaemic encephalopathy (NESHIE) is a neurological disorder caused by oxygen deprivation and limited blood flow to a neonate’s brain.
Priyal Mistry, Juanita Mellet, Chrisna Durandt, Izelle Smuts, Michael S. Pepper   +4 more
doaj   +2 more sources

Predictive modelling of hypoxic ischaemic encephalopathy risk following perinatal asphyxia

Heliyon, 2021
Hypoxic Ischemic Encephalopathy (HIE) remains a major cause of neurological disability. Early intervention with therapeutic hypothermia improves outcome, but prediction of HIE is difficult and no single clinical marker is reliable.
Catherine Mooney, Daragh O'Boyle, Mikael Finder   +2 more
exaly   +3 more sources

Neuroserpin: A Potential Neuroprotective Agent in Mild Neonatal Hypoxic–Ischaemic Encephalopathy [PDF]

Cells
Neonatal hypoxic–ischaemic encephalopathy (HIE) remains a leading cause of infant morbidity and mortality worldwide, with therapeutic hypothermia being the only clinically approved treatment.
Eri Kawashita, Yumi Fukuzaki, Jan Fischer, Lei Shi, Yumei Liao, Lancelot Jamie Millar, Peiyun Zhong, Anna Hoerder-Suabedissen, Luana Campos Soares, Zoltán Molnár   +9 more
doaj   +2 more sources

Epidemiology of neonatal encephalopathy and hypoxic–ischaemic encephalopathy

Early Human Development, 2010
Neonatal encephalopathy (NE) is the clinical manifestation of disordered neonatal brain function. Lack of universal agreed definitions of NE and the sub-group with hypoxic-ischaemia (HIE) makes the estimation of incidence and the identification of risk factors problematic. NE incidence is estimated as 3.0 per 1000 live births (95%CI 2.7 to 3.3) and for
Jennifer J Kurinczuk, Melanie White-Koning, Nadia Badawi   +2 more
exaly   +4 more sources

Rationale for the Use of Cord Blood in Hypoxic-Ischaemic Encephalopathy [PDF]

Stem Cells International, 2022
Hypoxic-ischaemic encephalopathy (HIE) is a severe complication of asphyxia at birth. Therapeutic hypothermia, the standard method for HIE prevention, is effective in only 50% of the cases. As the understanding of the immunological basis of these changes
Izabela Zdolińska-Malinowska, Dariusz Boruczkowski, Dominika Hołowaty, Paweł Krajewski, Emilian Snarski   +4 more
doaj   +2 more sources

Assessing Creatine Supplementation for Neuroprotection against Perinatal Hypoxic-Ischaemic Encephalopathy: A Systematic Review of Perinatal and Adult Pre-Clinical Studies

Cells, 2021
There is an important unmet need to develop interventions that improve outcomes of hypoxic-ischaemic encephalopathy (HIE). Creatine has emerged as a promising neuroprotective agent.
Nhi T Tran, Sharmony B Kelly, Rodney J Snow   +2 more
exaly   +3 more sources

The underlying molecular mechanisms of Fyn in neonatal hypoxic-ischaemic encephalopathy [PDF]

Frontiers in Cellular Neuroscience
Fyn is a cytoplasmic tyrosine kinase (TK) that is a nonreceptor and a member of the Src family of kinases (SFKs). It is involved in several transduction pathways in the central nervous system (CNS), such as oligodendrocyte development, myelination, axon ...
Jiao Zhou, Jiao Zhou, Xiang Lu, Haichuan Wang   +3 more
doaj   +2 more sources

Leveraging electronic medical record-embedded standardised electroencephalogram reporting to develop neonatal seizure prediction models: a retrospective cohort study

The Lancet: Digital Health, 2023
Summary: Background: Accurate prediction of seizures can help to direct resource-intense continuous electroencephalogram (CEEG) monitoring to neonates at high risk of seizures.
Jillian L McKee, MD, Michael C Kaufman, MS, Alexander K Gonzalez, MS, Mark P Fitzgerald, MD, Shavonne L Massey, MD, France Fung, MD, Sudha K Kessler, MD, Stephanie Witzman, BA, Nicholas S Abend, ProfMD, Ingo Helbig, MD   +9 more
doaj   +1 more source

Core outcomes in neonatal encephalopathy: a qualitative study with parents

BMJ Paediatrics Open, 2022
Objective To identify the outcomes considered important to parents or caregivers of infants diagnosed with neonatal encephalopathy, hypoxic ischaemic encephalopathy or birth asphyxia in high-income and low- to middle-income countries (LMiCs), as part of ...
Karen Walker, Mandy Daly, Eleanor Molloy, Malcolm Battin, Jamie J Kirkham, Shabina Ariff, Tim Hurley, Frank H Bloomfield, Declan Devane, Linda Biesty, Patricia Healy, Shireen Meher, Fiona Quirke, Caitlin Bernard, David M Haas, Vincent Kibet, Sarah Koskei, Maira Niaz, Elaine Ní Bhraonáin, Christabell Omukagah Okaronon, Farhana Tabassum   +20 more
doaj   +1 more source

Hypoxic ischaemic encephalopathy

Paediatrics and Child Health, 2014
Abstract Over the past several years, basic and clinical research has improved our understanding of critical cellular and molecular events which eventually lead to brain damage following perinatal hypoxia-ischaemia. The knowledge that perinatal hypoxia-ischaemia is a process that evolves over hours to days provides a "window of opportunity" for ...
Anitha James, Vaishali Patel
  +4 more sources