Results 31 to 40 of about 20,402 (269)

Regulated cell death in hypoxic-ischaemic encephalopathy: recent development and mechanistic overview. [PDF]

Cell Death Discov
Hypoxic-ischaemic encephalopathy (HIE) in termed infants remains a significant cause of morbidity and mortality worldwide despite the introduction of therapeutic hypothermia.
Wu L, Chang E, Zhao H, Ma D.
europepmc   +2 more sources

Abnormal expression and role of MicroRNA-214-3p/SLC8A1 in neonatal Hypoxic-Ischaemic encephalopathy. [PDF]

Int J Exp Pathol, 2023
Neonatal hypoxic‐ischaemic encephalopathy (HIE) refers to brain damage caused by intra‐uterine distress and asphyxia/hypoxia during the perinatal and neonatal periods. MicroRNA (MiR)‐214‐3p plays a critical role in cell growth and apoptosis.
Yang L, Zhang L, Zhu J, Wang Y, Zou N, Liu Z, Wang Y.   +6 more
europepmc   +2 more sources

Role of Pentoxifylline in neonatal hypoxic ischaemic encephalopathy: A systematic review of animal studies

, 2023
Systematic review of animal studies evaluating safety and efficacy of Pentoxifylline to treat hypoxic ischaemic encephalopathy in neonatal ...
Bhanu Gowda, Chandra Rath, Florence Wong, Sanjay Patole   +3 more
core   +2 more sources

Perinatal brain damage: The term infant

Neurobiology of Disease, 2016
Perinatal brain injury at term is common and often manifests with neonatal encephalopathy including seizures. The most common aetiologies are hypoxic–ischaemic encephalopathy, intracranial haemorrhage and neonatal stroke. Besides clinical and biochemical
Henrik Hagberg, A. David Edwards, Floris Groenendaal   +2 more
doaj   +1 more source

Motor function and white matter connectivity in children cooled for neonatal encephalopathy

NeuroImage: Clinical, 2021
Therapeutic hypothermia reduces the incidence of severe motor disability, such as cerebral palsy, following neonatal hypoxic-ischaemic encephalopathy. However, cooled children without cerebral palsy at school-age demonstrate motor deficits and altered ...
Arthur P.C. Spencer, Jonathan C.W. Brooks, Naoki Masuda, Hollie Byrne, Richard Lee-Kelland, Sally Jary, Marianne Thoresen, Marc Goodfellow, Frances M. Cowan, Ela Chakkarapani   +9 more
doaj   +1 more source

Intrapartum-related neonatal encephalopathy incidence and impairment at regional and global levels for 2010 with trends from 1990. [PDF]

, 2013
BACKGROUND: Intrapartum hypoxic events ("birth asphyxia") may result in stillbirth, neonatal or postneonatal mortality, and impairment. Systematic morbidity estimates for the burden of impairment outcomes are currently limited.
Vos, Theo, Cousens, Simon, Adil Bahalim, Susan Niermeyer, Lawn, Joy E, Naoko Kozuki, Theo Vos, Nicola J. Robertson, Ellis, Matthew, Matthew Ellis, Anne CC Lee, Joy E. Lawn, Robertson, Nicola J, Darmstadt, Gary L, Gary L. Darmstadt, Simon Cousens, Blencowe, Hannah, Lee, Anne CC, Kozuki, Naoko, Hannah Blencowe, Niermeyer, Susan, Bahalim, Adil   +21 more
core   +1 more source

Pilot randomized trial of therapeutic hypothermia with serial cranial ultrasound and 18-22 month follow-up for neonatal encephalopathy in a low resource hospital setting in Uganda: study protocol [PDF]

, 2011
Background: There is now convincing evidence that in industrialized countries therapeutic hypothermia for perinatal asphyxial encephalopathy increases survival with normal neurological function. However, the greatest burden of perinatal asphyxia falls in
Allen, Elizabeth, Allen Elizabeth, Cornelia F Hagmann, Jacobs Ian, Hagmann, Cornelia F., Nakakeeto Margaret, Elbourne, Diana, Jacobs, Ian, Ian Jacobs, Costello, Anthony, Frances Cowan, Acolet Dominique, Nicola J Robertson, Acolet, Dominique, Anthony Costello, Cowan Frances, Cowan, Frances, Acolet, D, Elbourne, D, Nyombi, Natasha, Robertson, Nicola J., Hagmann Cornelia F, Dominique Acolet, Robertson Nicola J, Robertson, NJ, Diana Elbourne, Margaret Nakakeeto, Nyombi Natasha, Cowan, F, Jacobs, I, Costello, A, Nakakeeto, Margaret, Robertson, Nicola J, Elbourne Diana, Hagmann, Cornelia F, Nakakeeto, M, Elizabeth Allen, Hagmann, CF, Nyombi, N, Allen, E, Costello Anthony, Natasha Nyombi   +41 more
core   +1 more source

Altered Cytokine Endotoxin Responses in Neonatal Encephalopathy Predict MRI Outcomes

Frontiers in Pediatrics, 2021
Background: Neonatal encephalopathy (NE) is associated with adverse neurodevelopmental outcome and is linked with systemic inflammation. Pro-inflammatory and anti-inflammatory cytokines are known to play a role in the pathology of NE by activating innate
Mary Isabel O'Dea, Mary Isabel O'Dea, Mary Isabel O'Dea, Mary Isabel O'Dea, Mary Isabel O'Dea, Mary Isabel O'Dea, Mary Isabel O'Dea, Mary Isabel O'Dea, Lynne A. Kelly, Lynne A. Kelly, Lynne A. Kelly, Ellen McKenna, Ellen McKenna, Tammy Strickland, Tammy Strickland, Tim P. Hurley, Tim P. Hurley, Tim P. Hurley, Tim P. Hurley, Tim P. Hurley, Tim P. Hurley, John Butler, Claudine Vavasseur, Afif F. EL-Khuffash, Afif F. EL-Khuffash, Jan Miletin, Jan Miletin, Lida Fallah, Arthur White, Jason Wyse, Eleanor J. Molloy, Eleanor J. Molloy, Eleanor J. Molloy, Eleanor J. Molloy, Eleanor J. Molloy, Eleanor J. Molloy   +35 more
doaj   +1 more source

Temporal evolution of electrographic seizures in newborn infants with hypoxic-ischaemic encephalopathy requiring therapeutic hypothermia: a secondary analysis of the ANSeR studies. [PDF]

Lancet Child Adolesc Health
Summary Background Despite extensive research on neonatal hypoxic-ischaemic encephalopathy, detailed information about electrographic seizures during active cooling and rewarming of therapeutic hypothermia is sparse.
Pavel AM, Rennie JM, de Vries LS, Mathieson SR, Livingstone V, Finder M, Foran A, Shah DK, Pressler RM, Weeke LC, Dempsey EM, Murray DM, Boylan GB, ANSeR Consortium.   +13 more
europepmc   +2 more sources

Cytokine dysregulation persists in childhood post Neonatal Encephalopathy

BMC Neurology, 2020
Background Cytokines are possible mediators of neuroinflammation and associated with adverse outcome in neonatal encephalopathy (NE). Our aim was to explore cytokine response in children with Neonatal Encephalopathy (NE) at school age compared to age ...
Zunera Zareen, Tammy Strickland, Victoria Mc Eneaney, Lynne A. Kelly, Denise McDonald, Deirdre Sweetman, Eleanor J. Molloy   +6 more
doaj   +1 more source