Results 21 to 30 of about 20,402 (269)

The Potential Clinical Relevance of Necrosis-Necroptosis Pathways for Hypoxic-Ischaemic Encephalopathy. [PDF]

Cells
Highlights What are the main findings? Necroptosis makes a major contribution to both early and delayed brain injury after perinatal hypoxia-ischaemia. Necroptotic signalling starts soon after hypoxia–ischaemia, remains active into the tertiary phase and
Lear BA, McDouall AJ, Lear OJ, Dhillon SK, Lear CA, Northington FJ, Bennet L, Gunn AJ.   +7 more
europepmc   +2 more sources

Association of caffeine with renal and other short-term outcomes in neonates with hypoxic-ischaemic encephalopathy undergoing therapeutic hypothermia. [PDF]

BMJ Paediatr Open
Objective To evaluate the association of caffeine with renal and other short-term clinical outcomes in neonates with moderate or severe hypoxic-ischaemic encephalopathy (HIE) undergoing therapeutic hypothermia (TH). Study design This retrospective cohort
Lavu R, Nicoletti N, Worley S, Puthuraya S, Aly H, Acun C.   +5 more
europepmc   +2 more sources

Placental histology for infants with hypoxic ischaemic encephalopathy compared with healthy controls: a case-control study. [PDF]

BMC Pediatr
The role of the placenta in the development of hypoxic ischaemic encephalopathy (HIE) remains undefined. There is limited research comparing placental histology for infants with HIE and healthy controls.
Fox Á, Doyle E, Reynolds A, Geary M, Cuzzilla R, Hayes B.   +5 more
europepmc   +2 more sources

Therapeutic hypothermia for neonatal hypoxic ischaemic encephalopathy in Sub-Saharan Africa: A scoping review. [PDF]

PLoS One
Introduction There are divergent views and limited data regarding therapeutic hypothermia (TH) for neonatal hypoxic ischaemic encephalopathy (HIE) in sub-Saharan Africa (SSA).
Buxton-Tetteh NA, Pillay S, Kali GTJ, Horn AR.   +3 more
europepmc   +2 more sources

Genetic Variants Associated with Suspected Neonatal Hypoxic Ischaemic Encephalopathy: A Study in a South African Context. [PDF]

Int J Mol Sci
Neonatal encephalopathy suspected to be due to hypoxic ischaemic encephalopathy (NESHIE) carries the risk of death or severe disability (cognitive defects and cerebral palsy).
Foden CJ, Durant K, Mellet J, Joubert F, van Rensburg J, Masemola K, Velaphi SC, Nakwa FL, Horn AR, Pillay S, Kali G, Coetzee M, Ballot DE, Kalua T, Babbo C, Pepper MS, NESHIE Working Group.   +16 more
europepmc   +2 more sources

Minimal impact of feed intolerance during therapeutic hypothermia for hypoxic ischaemic encephalopathy in a South African cohort with a standardised feeding regimen. [PDF]

Front Pediatr
Introduction Enteral feeding during therapeutic hypothermia (TH) for neonatal hypoxic ischaemic encephalopathy (HIE), is beneficial, but there is insufficient evidence to guide timing and feed advancement strategies. The aim of this study was to describe
Samaai I, Pepper MS, Pillay S, Horn AR.
europepmc   +2 more sources

Hypoglycaemia and hypoxic–ischaemic encephalopathy [PDF]

Developmental Medicine & Child Neurology, 2015
The transition from fetal to neonatal life requires metabolic adaptation to ensure that energy supply to vital organs and systems is maintained after separation from the placental circulation. Under normal conditions, this is achieved through the mobilization and use of alternative cerebral fuels (fatty acids, ketone bodies, and lactate) when blood ...
James P, Boardman, Jane M, Hawdon
openaire   +2 more sources

Validation of a machine learning algorithm for identifying infants at risk of hypoxic ischaemic encephalopathy in a large unseen data set. [PDF]

Arch Dis Child Fetal Neonatal Ed
Objective To validate a hypoxic ischaemic encephalopathy (HIE) prediction algorithm to identify infants at risk of HIE immediately after birth using readily available clinical data.
Murray AL, O'Boyle DS, Walsh BH, Murray DM.   +3 more
europepmc   +2 more sources

Hypothermia as a treatment option for hypoxic-ischemic encephalopathy in newborns – A literature review

Journal of Education, Health and Sport, 2022
Introduction and purpose: Neonatal asphyxia is a medical condition in which the neonate is not able to maintain sufficient respiratory function. The hypoxia may be caused by either an impaired respiratory activity of the neonate or an interruption of ...
Weronika Urbaś, Klaudia Artykiewicz, Marcin Czarkowski, Kamila Gorczyca, Maria Grodkiewicz, Paweł Kozieł, Urszula Krzysiek, Klaudia Podgórska, Aleksandra Puła, Aleksandra Słupczyńska   +9 more
doaj   +1 more source

Acute High Dose Melatonin for Encephalopathy of the Newborn (ACUMEN) Study: a protocol for a multicentre phase 1 safety trial of melatonin to augment therapeutic hypothermia for moderate/severe hypoxic ischaemic encephalopathy. [PDF]

BMJ Open
Introduction Neonatal death and later disability remain common sequelae of hypoxic-ischaemic encephalopathy (HIE) despite the now standard use of therapeutic hypothermia (HT). New therapeutic approaches to brain protection are required.
Pang R, Macneil A, Wadke A, Jaami Y, Marlow N, Standing JF, Dehbi HM, Tranter P, Robertson NJ, ACUMEN Consortium.   +9 more
europepmc   +2 more sources