Results 61 to 70 of about 48,292 (244)

Resolution of generalized tonic seizures following focal ablative or resective surgery

Epileptic Disorders, EarlyView.
Abstract Objective Focal brain lesions may underlie generalized tonic seizures, as seen in Lennox–Gastaut syndrome, by engaging bilateral neural networks. However, this seizure type is often not considered surgically remediable. Here, we describe the resolution of apparent electroclinically classic generalized tonic seizures in children originating ...
Sem L. Kampman, Itay Tokatly Latzer, Aaron E. L. Warren, Jurriaan M. Peters   +3 more
wiley   +1 more source

Behavioral and epileptic phenotypes in a CHD2‐related developmental delay model

Epilepsia, EarlyView.
Abstract Objective Heterozygous loss‐of‐function mutations in the CHD2 gene, encoding chromodomain helicase DNA‐binding protein 2, are associated with severe childhood onset epilepsy, global developmental delay, and autistic features. Animal models that accurately recapitulate human phenotypes are crucial for understanding rare neurodevelopmental ...
Anat Mavashov, Shaked Turk, Yael Sarusi, Marina Brusel, Rotem Ben Tov Perry, Shir Quinn, Yael Almog, Karni Vilian, Mor Yam, Igor Ulitsky, Moran Rubinstein   +10 more
wiley   +1 more source

Evolution of the European Medicines Agency clinical guidelines for epilepsy drug development between 2010 and 2025: A comparative analysis by the ILAE Task Force on Regulatory Affairs

Epilepsia, EarlyView.
Abstract Objective The latest European Medicines Agency (EMA) guideline on the clinical investigation of medicines to treat epileptic disorders was adopted by the EMA Committee for Medicinal Products for Human Use in 2025. We compared this guideline with the previous version (2010), highlighting areas where significant revisions were introduced ...
Stéphane Auvin, Alexis Arzimanoglou, Jacqueline French, Kelly G. Knupp, Lieven Lagae, Eugen Trinka, Dennis Dlugos, Emilio Perucca   +7 more
wiley   +1 more source

The Usefulness of Serum Brain Damage Biomarkers in Detection and Evaluation of Hypoxic Ischemic Encephalopathy in Calves with Perinatal Asphyxia

Animals, 2022
The purpose of the present study was to determine hypoxic brain damage in calves with perinatal asphyxia using brain-specific damage biomarkers. Ten healthy and 25 calves with perinatal asphyxia were enrolled in the study.
Mahmut Ok, Amir Naseri, Mehmet Burak Ates, Merve Ider, Kamil Uney, Mutlu Sevinc, Fatih Hatipoglu, Ramazan Yildiz, Alper Erturk, Nuri Baspinar, Suleyman Serhat Iyigun   +10 more
doaj   +1 more source

Neonatal hypoxic-ischemic encephalopathy diagnosis and treatment: a National Survey in China

BMC Pediatrics, 2021
Background Neonatal hypoxic-ischemic encephalopathy (HIE) affects as many as 100,000 infants each year in China. Therapeutic hypothermia reduces HIE related mortality and long-term neurodevelopmental disabilities.
Zheng Wang, Peng Zhang, Wen-Hao Zhou, S. Xia, Wei Zhou, Xiaoyu Zhou, Xiuyong Cheng, Yuan Shi, Zhenlang Lin, Dongli Song, G. Cheng   +10 more
semanticscholar   +1 more source

Lactate receptor HCAR1 in neonatal hypoxic–ischemic seizures

Epilepsia, EarlyView.
Abstract Hydroxycarboxylic acid receptor 1 (HCAR1) is a G‐protein‐coupled lactate receptor expressed in the brain and plays a role in neuronal excitability and repair after injury. Hypoxic–ischemic encephalopathy (HIE) is the most common cause of brain injury and seizures in term neonates.
Jennifer Burnsed, Angelina June, Maria Marlicz, Emmy Zucker, Ellie Kain‐Kuzniewski, Hannah Mulhern, Leanne Maharaj, John Williamson, Chengsan Sun, Suchitra Joshi, Huayu Sun, Jaideep Kapur   +11 more
wiley   +1 more source

Time of day/unit busyness at birth and perinatal hypoxia and or moderate to severe hypoxic ischemic encephalopathy a cohort study

The Journal of Maternal-Fetal & Neonatal Medicine
Objectives To investigate the potential link between nighttime births, unit busyness, and the incidence of perinatal hypoxia or moderate-to-severe hypoxic-ischemic encephalopathy.Methods Retrospective cohort study with nested case control study of all ...
Stephen Wood, Selphee Tang, Khorsid Mohammad, Matt Hicks   +3 more
doaj   +1 more source

Basic biochemical and hematological parameters in perinatal asphyxia and their correlation with hypoxic ischemic encephalopathy.

Experimental and Therapeutic Medicine, 2021
Perinatal hypoxic-ischemic encephalopathy (HIE) represents a major cause of neonatal death or long-term disability. Inflammation plays an important role in mediating brain damage induced by neonatal hypoxic-ischemic encephalopathy.
A. Munteanu, A. Manea, C. Jincă, M. Boia   +3 more
semanticscholar   +1 more source

Neonatal seizures: Advances in diagnosis and management

Epilepsia Open, EarlyView.
Abstract The International League Against Epilepsy (ILAE) created the ILAE Neonatal Task Force that classified neonatal seizures, defined neonatal epilepsy syndromes, and specified treatment guidelines. These frameworks, in addition to improved access to genetic testing and other recent advances, have revolutionized the diagnosis and management of ...
Elissa G. Yozawitz, Ronit M. Pressler, Eli M. Mizrahi   +2 more
wiley   +1 more source

Restricted diffusion in the corpus callosum: A neuroradiological marker in hypoxic–ischemic encephalopathy

Indian Journal of Radiology and Imaging, 2016
Background: Restricted diffusion within the splenium of the corpus callosum has been described by other authors in various conditions, however, restricted diffusion in the entire corpus callosum or isolated involvement of the splenium, genu, or body has ...
Alok Kale, Priscilla Joshi, A Kelkar
doaj   +1 more source