Hypsarhythmia or Hypsarrhythmia?
Hypsarhythmia was originally spelled with one ‘r’ by Drs Frederick and Erna Gibbs when they coined the term in 1952.
John J. Millichap, J. Gordon Millichap
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Hypsarrhythmia Variant Patterns
The frequency of hypsarrhythmia variant or atypical patterns was determined by analysis of pre-ACTH EEG records of 53 consecutive patients with infantile spasms at Children’s Hospital, Harvard Medical School, Boston, MA.
J Gordon Millichap
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Distributed EEG source localization of hypsarrhythmia in west syndrome: a standardized, low-resolution, brain electromagnetic tomography (sLORETA) study [PDF]
Background West syndrome is a developmental epileptic encephalopathy characterized by epileptic spasms, hypsarrhythmia, and neurodevelopmental regression.
Jooyoung Lee +6 more
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Quantification of Hypsarrhythmia in Infantile Spasmatic EEG: A Large Cohort Study [PDF]
Infantile spasms (IS) is a neurological disorder causing mental and/or developmental retardation in many infants. Hypsarrhythmia is a typical symptom in the electroencephalography (EEG) signals with IS.
Ruolin Hou +13 more
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Association of serum insulin-like growth factor-1 and adrenocorticotropic hormone therapeutic response in patients with infantile epileptic spasms syndrome [PDF]
BackgroundInfantile epileptic spasm syndrome (IESS), a rare age-specific epileptic encephalopathy, exhibits limited therapeutic efficacy, with approximately 50% of patients showing resistance to adrenocorticotropic hormone (ACTH) monotherapy.
Ka-Na Lin +9 more
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The clinical, EEG, and radiological findings in 6 patients with the asymmetric variant of hypsarrhythmia among 26 children with infantile spasms are reported from the University of Michigan EEG Laboratory, Ann Arbor, MI.
J Gordon Millichap
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Identification of Hypsarrhythmia in Children with Microcephaly Infected by Zika Virus [PDF]
Hypsarrhythmia is an electroencephalographic pattern specific to some epileptic syndromes that affect children under one year of age. The identification of this pattern, in some cases, causes disagreements between experts, which is worrisome since an ...
Gean Carlos Sousa +6 more
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ACTH Therapy in Epileptic Spasms without Hypsarrhythmia
The short and long-term effects of adrenocorticotrophic hormone (ACTH) in 30 children ages 11 to 86 months (median 29 months) with epileptic spasms (ES) without hypsarrhythmia were analyzed at Tokyo Women’s Medical University, Japan.
J Gordon Millichap
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Infantile Spasms, Hypsarrhythmia, and Adrenoleukodystrophy (ALD)
An 8 1/2 month-old girl with seizures beginning at 5 days, hypsarrhythmia in the EEG, severe retardation, and a clinical diagnosis of infantile spasms was discovered to have biochemical and pathological features of adrenoleukodystrophy, as reported from ...
J Gordon Millichap
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Oral Prednisolone vs. IM Corticotropin and Hypsarrhythmia* in West Syndrome [PDF]
Investigators at University of Columbo, Sri Lanka, studied the efficacy of oral prednisolone (40-60 mg/day) and intramuscular adrenocorticotrophin hormone (40-60 IU synthetic ACTH every other day) for 14 days in improving hypsarrhythmia in children (age ...
J Gordon Millichap, John J Millichap
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