Results 81 to 90 of about 16,226,491 (322)

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Randomized crossover comparison of the laryngeal mask airway classic with i-gel laryngeal mask airway in the management of difficult airway in post burn neck contracture patients

Indian Journal of Anaesthesia, 2012
Purpose: The objective of the study was to compare the performance of i-gel supraglottic airway with cLMA in difficult airway management in post burn neck contracture patients and assess the feasibility of i-gel use for emergency airway management in ...
Jeevan Singh, Manohar Kumar Yadav, Sujan Babu Marahatta, Bikash Lal Shrestha   +3 more
doaj   +1 more source

Comparison of oropharyngeal leak pressure and clinical performance of LMA ProSeal™ and i-gel® in adults: Meta-analysis and systematic review

Journal of International Medical Research, 2016
Background A meta-analysis and systematic review of randomized controlled trials to compare the oropharyngeal leak pressure (OLP) and clinical performance of LMA ProSeal™ (Teleflex® Inc., Wayne, PA, USA) and i-gel® (Intersurgical Ltd, Wokingham, UK) in ...
H. Shin, Hae Na Yoo, G. Bae, Jun Chul Chang, Min Kyung Park, Hae Seun You, H. Kim, H. Ahn   +7 more
semanticscholar   +1 more source

i-gel™ supraglottic airway in clinical practice: a prospective observational multicentre study [PDF]

, 2017
Background The i-gel™ supraglottic airway device has been studied in randomized controlled studies, but it has not been evaluated in a large prospective patient cohort.
Greif, R., Gutzmann, M., Kaempfen, B., Kleine-Brueggeney, M., Theiler, L., Urwyler, N.   +5 more
core  

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

EASE OF INSERTION OF LARYNGEAL MASK AIRWAY BY CLASSIC AND I GEL SUPRAGLOTTICAIRWAY DEVICES- ACOMPARATIVESTUDY [PDF]

Perspectives In Medical Research, 2019
BACKGROUND: Laryngeal mask airway is a supraglottic airway device with an inflatable cuffforming a low-pressure seal around the laryngeal inlet and permitting ventilation.
PVenketashwar Reddy 1, Nikhil Mugdalkar2
doaj  

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Interplay between Spinodal Decomposition and Glass Formation in Proteins Exhibiting Short-Range Attractions

, 2009
We investigate the competition between spinodal decomposition and dynamical arrest using aqueous solutions of the globular protein lysozyme as a model system for colloids with short-range attractions.
Anna Stradner, E. Zaccarelli, Frédéric Cardinaux, Peter Schurtenberger, Thomas Gibaud   +4 more
core   +1 more source

Colon cancer cell-derived 12(S)-HETE induces the retraction of cancer-associated fibroblast via MLC2, RHO/ROCK and Ca2+ signalling [PDF]

, 2016
Retraction of mesenchymal stromal cells supports the invasion of colorectal cancer cells (CRC) into the adjacent compartment. CRC-secreted 12(S)-HETE enhances the retraction of cancer-associated fibroblasts (CAFs) and therefore, 12(S)-HETE may enforce ...
Bago-Horvath, Zsuzsanna, Brendel, Konstantin Alexander, Brenner, Stefan, De Wever, Olivier, Dolznig, Helmut, Eichsteininger, Julia, Giessrigl, Benedikt, Holzner, Silvio, Huttary, Nicole, Jäger, Walter, Koperek, Oskar, Krenn, Liselotte, Krieger, Sigurd, Krupitza, Georg, Mader, Robert M, Marian, Brigitte, Milovanovic, Daniela, Nguyen, Chi Huu, Schachner, Helga, Schmidt, Wolfgang M, Senfter, Daniel, Stadler, Mira, Stadler, Serena   +22 more
core   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source