Results 251 to 260 of about 174,637 (308)

Targeting the Osteopontin-regulated PI3K/AKT signaling pathway: A molecular approach to overcome drug resistance and metastasis in gastrointestinal tumors. [PDF]

World J Gastrointest Oncol
Nian H, Bai Y, Wang HY, Yu H, Zhang ZL, Shi RH, Zhang S, Wu YB, Zhou DH, Du QC.   +9 more
europepmc   +1 more source

A 50‐year‐old man with a 12‐year history of extensive pachymeningeal thickening

Brain Pathology, EarlyView.
Alyssa M. Lee, Siddhartha Gaddamanugu, Kathyrn L. Eschbacher, Aishwarya Ravindran   +3 more
wiley   +1 more source

Targeting Inflammation and Immune Regulation in Chronic Inflammation Associated Cancers

Cancer Science, EarlyView.
Chronic inflammation sustains activation of key inflammatory pathways, including Nuclear factor kappa B (NF‐κB), Interleukin‐6‐signal transducer and activator of transcription 3 (IL6‐STAT3), Phosphoinositide 3‐kinase/Akt (PI3K/Akt), and Wingless/β‐catenin (Wnt/β‐catenin) signaling. This promotes immune dysregulation through the expansion and functional
Lawan Rabiu, Mengzhu Chinn, Feng Chen, Yerkezhan Yerkinkazhina, Yuan Tian, Wei‐Guo Zhu   +5 more
wiley   +1 more source

Autophagy in Rheumatoid Arthritis: Molecular Mechanisms, Diagnostic Biomarkers, and Emerging Therapeutic Strategies. [PDF]

Inflammation
Nasrollahizadeh A, Rahmati S, Chahkand MSG, Moallem FE, Azarm E, Dadkhah PA, Karimi M, Amini-Salehi E, Karimi MA.   +8 more
europepmc   +1 more source

Acalabrutinib in Chronic Lymphocytic Leukemia: Pharmacology and Emerging Clinical Perspectives

European Journal of Haematology, EarlyView.
ABSTRACT Acalabrutinib, a second‐generation Bruton's tyrosine kinase inhibitor (BTKi), is characterized by enhanced specificity and selectivity for BTK with minimal off‐target effects, offering a significant evolution in the treatment of chronic lymphocytic leukemia (CLL). Its mechanism of action, a covalent binding to Cys481 within the BTK active site,
Gianluca Gaidano, Romano Danesi
wiley   +1 more source

Chaihu-Shugan-San ameliorates chronic atrophic gastritis by inhibiting nuclear factor-kappa B-mediated inflammation and apoptosis. [PDF]

World J Gastroenterol
Song J, Li DY, Zhang XL, He SS, Wang N, Zhang HC, Bai YJ, Li B, Zhang SS.   +8 more
europepmc   +1 more source

Bibliometric analysis and core target identification of network pharmacology on neuroinflammation in central nervous system disorders: Trends, collaborations, and future directions. [PDF]

Neuroprotection
Zhang Y, Hou S, Li J, Wang W, Jia S, Wang X, Xia Y, Wang Y.   +7 more
europepmc   +1 more source

Brain demyelination is crucially dependent on the I kappa B kinase complex in vivo

, 2018
Prinz, Marco R., van Loo, Geert, Pasparakis, Manolis   +2 more
openaire   +1 more source

Cytosolic nucleic acid sensing triggers type I interferon activation via the Hippo kinase LATS1. [PDF]

J Biol Chem
Nass T, Reichardt AD, Aliyari SR, Tom E, LeMunyan G, Parvatiyar MS, Cheng G, Parvatiyar K.   +7 more
europepmc   +1 more source

Decoding TREM2 Signaling Pathways: Linking Macrophage Glycolysis to Inflammatory Diseases in the CNS. [PDF]

Neurol Neuroimmunol Neuroinflamm
Che Y, Yu Z, Ji S, Yang D.
europepmc   +1 more source