Results 261 to 270 of about 174,637 (308)

Inhibition of Inflammation by an Air-Based No-Ozone Cold Plasma in TNF-α-Induced Human Keratinocytes: An In Vitro Study. [PDF]

Curr Issues Mol Biol
Choi BB, Park SA, Choi JH, Kim MK, Choi YD, Lee HW, Kim GC.   +6 more
europepmc   +1 more source

In Silico Assessment of Potential Geroprotectors: From Separate Endpoints to Complex Pharmacotherapeutic Effects. [PDF]

Int J Mol Sci
Stolbov L, Rudik A, Lagunin A, Druzhilovskiy D, Filimonov D, Poroikov V.   +5 more
europepmc   +1 more source

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Development and comparison of two nonradioactive kinase assays for I kappa B kinase

Analytical Biochemistry, 2004
In response to diverse stimuli, the transcription factor NF-kappaB is activated by the IKK kinase complex containing two kinases (IKKalpha and IKKbeta) that phosphorylate IkappaB, an inhibitory protein of NF-kappaB. The phosphorylation of IkappaB results in ubiquitination and degradation of IkappaB, allowing NF-kappaB to translocate to the nucleus ...
Tammy M, Sadler, Maria, Achilleos, Shoba, Ragunathan, Adam, Pitkin, James, LaRocque, John, Morin, Rebecca, Annable, Lee M, Greenberger, Philip, Frost, Yixian, Zhang   +9 more
openaire   +2 more sources

Proteasome inhibitors induce inhibitory kappa B (I kappa B) kinase activation, I kappa B alpha degradation, and nuclear factor kappa B activation in HT-29 cells.

Molecular pharmacology, 2004
The transcription factor nuclear factor kappaB (NF-kappaB) is activated and seems to promote oncogenesis in certain cancers. A major mechanism of NF-kappaB activation in cells involves cytoplasm-to-nucleus translocation of this transcription factor after hydrolysis of the cytoplasmic inhibitor inhibitory kappaB (IkappaB) by the 26S proteasome.
Zoltán H, Németh, Hector R, Wong, Kelli, Odoms, Edwin A, Deitch, Csaba, Szabó, E Sylvester, Vizi, György, Haskó   +6 more
openaire   +2 more sources

Gingerenone A Attenuates Monocyte‐Endothelial Adhesion via Suppression of I Kappa B Kinase Phosphorylation

Journal of Cellular Biochemistry, 2017
ABSTRACTDuring the early stages of atherosclerosis, monocytes bind and migrate into the endothelial layer, promoting inflammation within the aorta. In order to prevent the development of atherosclerosis, it is critical to inhibit such inflammation. The therapeutic effects of ginger have been investigated in several models of cardiovascular disease ...
Hee Joo Kim, Joe Eun Son, Jae Hwan Kim, Charles C. Lee, Hee Yang, Soonham Sami Yaghmoor, Youssri Ahmed, Jehad Mustafa Yousef, Khalid Omer Abualnaja, Abdulrahman Labeed Al‐Malki, Taha Abdullah Kumosani, Jong Hun Kim, Jung Han Yoon Park, Chang Yong Lee, Jong‐Eun Kim, Ki Won Lee   +15 more
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The zinc finger mutation C417R of I-kappa B kinase gamma impairs lipopolysaccharide- and TNF-mediated NF-kappa B activation through inhibiting phosphorylation of the I-kappa B kinase beta activation loop.

Journal of immunology (Baltimore, Md. : 1950), 2004
The activation of the I-kappaB kinase (IKK) complex by TNF or LPS stimulates phosphorylation and degradation of I-kappaBalpha, leading to the nuclear translocation of NF-kappaB. The IKK complex is mainly composed of two catalytic subunits, IKKalpha and IKKbeta, and a chaperon subunit IKKgamma.
Fan, Yang, Junro, Yamashita, Eric, Tang, Hom-Lay, Wang, Kunliang, Guan, Cun-Yu, Wang   +5 more
openaire   +2 more sources

Abstract LB-144: I-kappa-B kinase (IKK)ε expression in pancreatic ductal adenocarcinoma

Cancer Research, 2011
Abstract I-kappa-B-kinase (IKKε) is a serine/threonine protein kinase that belongs to the IKK kinase family. Recent studies have shown that IKKε functions as a breast and ovarian cancer oncogene. Here we demonstrate frequent overexpression of IKKε in pancreatic ductal adenocarcinoma (PDA).
Jianping Guo, Anna Cheng, Evita B. Henderson-Jackson, Donghwa Kim, Mokenge Malafa, Domenico Coppola   +5 more
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Targeting the I-Kappa-B Kinase Epsilon (IKKe) for Breast Cancer Therapy

2009
Abstract : IKK(Epsilon) has been recently identified as a breast cancer oncogene. Although it is believed that the kinase activity of IKK(epsilon) is essential for its oncogene activity, its mechanism in turmogenesis and therapeutic potential are not fully understood.
Bin Qin, Kun Cheng
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NF-kappa B regulation by I kappa B kinase in primary fibroblast-like synoviocytes.

Journal of immunology (Baltimore, Md. : 1950), 1999
NF-kappa B is a key regulator of inflammatory gene transcription and is activated in the rheumatoid arthritis (RA) synovium. In resting cells, NF-kappa B is retained as an inactive cytoplasmic complex by its inhibitor, I kappa B. Phosphorylation of I kappa B targets it for proteolytic degradation, thereby releasing NF-kappa B for nuclear translocation.
K R, Aupperle, B L, Bennett, D L, Boyle, P P, Tak, A M, Manning, G S, Firestein   +5 more
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I-kappa B kinase beta is critical for B cell proliferation and antibody response.

Journal of immunology (Baltimore, Md. : 1950), 2002
The NF-kappaB proteins are critical in the regulation of the immune and inflammatory response. Stimulation of the NF-kappaB pathway leads to increases in I-kappaB kinase beta (IKKbeta) kinase activity to result in the enhanced phosphorylation and degradation of I-kappaB and the translocation of the NF-kappaB proteins from the cytoplasm to the nucleus ...
Hong, Ren, Aurelia, Schmalstieg, Dorothy, Yuan, Richard B, Gaynor   +3 more
openaire   +1 more source