Results 271 to 280 of about 174,637 (308)

NF-kappa B regulation by I kappa B kinase-2 in rheumatoid arthritis synoviocytes.

Journal of immunology (Baltimore, Md. : 1950), 2001
IkappaB kinase-1 and IkappaB kinase-2 (IKK1 and IKK2; also called IKKalpha and IKKbeta, respectively) are part of the signal complex that regulates NF-kappaB activity in many cell types, including fibroblast-like synoviocytes (FLS). We determined which of these two kinases is responsible for cytokine-induced NF-kappaB activation in synoviocytes and ...
K, Aupperle, B, Bennett, Z, Han, D, Boyle, A, Manning, G, Firestein   +5 more
openaire   +1 more source

Thiol-reactive metal compounds inhibit NF-kappa B activation by blocking I kappa B kinase.

Journal of immunology (Baltimore, Md. : 1950), 2000
Gold compounds are used in the treatment of rheumatoid arthritis. NF-kappa B is a transcription factor implicated in the expression of many inflammatory genes. NF-kappa B is activated by signal-induced phosphorylation and subsequent degradation of inhibitory I kappa B (inhibitory protein that dissociates from NF-kappa B) proteins, and a multisubunit I ...
K I, Jeon, J Y, Jeong, D M, Jue
openaire   +1 more source

The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling.

Seminars in immunology, 2000
NF-kappa B is a heterodimeric transcription factor that plays a key role in inflammatory and immune responses. In nonstimulated cells, NF-kappa B dimers are maintained in the cytoplasm through interaction with inhibitory proteins, the I kappa Bs. In response to cell stimulation, mainly by proinflammatory cytokines, a multisubunit protein kinase, the I ...
M, Karin, M, Delhase
openaire   +1 more source

Activation of NF-kappa B by the dsRNA-dependent protein kinase, PKR involves the I kappa B kinase complex.

Oncogene, 2000
Besides its known role as a translational controlling factor, the double stranded RNA-dependent protein kinase (PKR) is a key transcriptional regulator exerting antiviral and antitumoural activities. We have recently described that induction of NF-kappa B by PKR is involved in apoptosis commitment.
J, Gil, J, Alcamí, M, Esteban
openaire   +1 more source

I kappa B kinase (IKK)-epsilon targets interferon regulatory factor 1 in activated T lymphocytes

2014
IB kinase (IKK-) has an essential role as a regulator of innate immunity, functioning downstream of pattern recognition receptors to modulate NF-B and interferon (IFN) signaling. In the present study, we investigated IKK- activation following T cell receptor (TCR)/CD28 stimulation of primary CD4 T cells and its role in the stimulation of a type I IFN ...
Sgarbanti M, Marsili G, Remoli AL, Stellacci E, MAI, Antonello, ROTILI, Dante, Perrotti E, Acchioni C, Orsatti R, Iraci N, Ferrari M, Borsetti A, Hiscott J, Battistini A.   +13 more
openaire   +2 more sources

The signal transduction pathway of CD23 (Fc epsilon RIIb) targets I kappa B kinase.

Journal of immunology (Baltimore, Md. : 1950), 1999
Alveolar macrophages play a crucial role in initiating the inflammatory response in allergic asthma through the cross-linking of the low affinity IgE receptors (Fc epsilon RIIb or CD23) by IgE-allergen immunocomplexes. We have previously shown that CD23 cross-linking in monocytes and U937 cells targets I kappa B alpha, leading to the activation of the ...
R M, Ten, M J, McKinstry, S A, Trushin, S, Asin, C V, Paya   +4 more
openaire   +1 more source

Phosphorylation and ubiquitination of the I kappa B kinase complex by two distinct signaling pathways (B29)

The Journal of Immunology, 2007
Abstract The IκB kinase (IKK) complex serves as the master regulator for the activation of NF-κB by various stimuli. It contains two catalytic subunits, IKKα and IKKβ, and a regulatory subunit, IKKγ/NEMO. The activation of IKK complex is dependent on the phosphorylation of IKKα/β at its activation loop, and the K63-linked ubiquitination ...
openaire   +1 more source

The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-kappa B by targeting the I kappa B kinase complex.

Journal of immunology (Baltimore, Md. : 1950), 1999
The transcription factor NF-kappa B is a key regulator of the cellular inflammatory and immune response. Therefore, components of the NF-kappa B-activating signaling pathways are frequent targets for antiinflammatory agents. This study shows that the sesquiterpene lactone parthenolide inhibits a common step in NF-kappa B activation by preventing the ...
S P, Hehner, T G, Hofmann, W, Dröge, M L, Schmitz   +3 more
openaire   +1 more source

Selenium compounds inhibit I kappa B kinase (IKK) and nuclear factor-kappa B (NF-kappa B) in prostate cancer cells.

Molecular cancer therapeutics, 2003
Selenium compounds are potential chemopreventive agents for prostate cancer. There are several proposed mechanisms for their anticancer effect, including enhanced apoptosis of transformed cells. Because the transcription factor nuclear factor-kappa B (NF-kappa B) is often constitutively activated in tumors and is a key antiapoptotic factor in mammalian
Alexander V, Gasparian, Ya Juan, Yao, Junxuan, Lü, Alexander Y, Yemelyanov, Lyudmila A, Lyakh, Thomas J, Slaga, Irina V, Budunova   +6 more
openaire   +1 more source

Targeting I kappa B kinase for the treatment of inflammatory and other disorders.

Current opinion in drug discovery & development, 2003
The nuclear transcription factor NF kappa B plays a critical role in the pathogenesis of a number of human disorders, particularly those with an inflammatory component. Due to the fact that I kappa B kinase (IKK)-catalyzed phosphorylation of I kappa B proteins is an essential step in the signal-induced activation of NF kappa B, targeting this kinase ...
openaire   +1 more source