Results 71 to 80 of about 174,637 (308)

Ascorbic Acid Modulates Collagen Properties in Glucocorticoid‐Induced Osteoporotic Bone: Insights into Chemical, Mechanical, and Biological Regulation

Advanced Healthcare Materials, EarlyView.
Osteoporosis from long‐term glucocorticoid (GIOP) use elevates susceptibility to fracture. This study shows GCs impair ascorbic acid (AA) metabolism in osteoblasts, collagen synthesis and extracellular matrix integrity. AA enhanced collagen biochemical and mechanical properties and restored osteoblast and endothelial function. These findings underscore
Micaila DE Curtis, Yoontae Kim, Rahul Patil, Xinran Zhang, Meth Jayatilake, Orelle Bulgin, Peter Lialios, Sana Surrency, Soraya Tarrah, Argyris K. Lazaris, Alison Grafton, James Williams IV, Seyedeh Boshra Nouraie, Maria Bizaki, Penelope Xeron, Edward Van Keuren, Jonathan E. Seppala, Evagelia C. Laiakis, Joanna B. Kitlinska, Stella Alimperti   +19 more
wiley   +1 more source

Design, synthesis, and biological evaluation of novel EF24 and EF31 analogs as potential IκB kinase β inhibitors for the treatment of pancreatic cancer

Drug Design, Development and Therapy, 2017
Xuemeng Xie, Jinfu Tu, Heyi You, Bingren Hu Department of Laparoscopic Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China Abstract: Given the important role that inhibitory kappa B (I ...
Xie X, Tu J, You H, Hu B
doaj  

Regulation of I(kappa)B kinase complex by phosphorylation of (gamma)-binding domain of I(kappa)B kinase (beta) by Polo-like kinase 1.

The Journal of biological chemistry, 2009
IkappaB kinase (IKK) complex is a key regulator of NF-kappaB pathways. Signal-induced interaction of the IKKgamma (NEMO) subunit with the C-terminal IKKgamma/NEMO-binding domain (gammaBD) of IKKbeta is an essential interaction for IKK regulation. Underlying regulatory mechanism(s) of this interaction are not known.
Tomoyasu, Higashimoto, Nymph, Chan, Yung-Kang, Lee, Ebrahim, Zandi   +3 more
openaire   +1 more source

A p38MAPK/MK2 signaling pathway leading to redox stress, cell death and ischemia/reperfusion injury [PDF]

, 2014
Background Many diseases and pathological conditions are characterized by transient or constitutive overproduction of reactive oxygen species (ROS).
Ashraf, Muhammad Imtiaz, Brandacher, Gerald, Dragun, Duska, Ebner, Matthias, Enthammer, Marion, Haller, Martina, Hermann, Martin, Khalid, Sana, Koziel, Katarzyna, Santer, Peter, Schwelberger, Hubert, Sickinger, Stephan, Soleiman, Afschin, Steger, Christina, Sucher, Robert, Troppmair, Jakob, Vallant, Stephanie, Wallner, Christoph   +17 more
core   +2 more sources

Domain-mediated interactions for protein subfamily identification [PDF]

, 2020
Within a protein family, proteins with the same domain often exhibit different cellular functions, despite the shared evolutionary history and molecular function of the domain.
Han S.K., Kim D., Kim I., KIM, SANGUK, Kong J., Lee H.   +5 more
core   +1 more source

Simvastatin Restores Uteroplacental Hemodynamics and Trophoblast Function in Obstetric Antiphospholipid Syndrome in a Placenta‐on‐a‐Chip Model

Advanced Healthcare Materials, EarlyView.
Simvastatin mitigates placental hypoperfusion in OAPS by ameliorating abnormal uteromaternal hemodynamics and enhancing trophoblast invasion via optimized endothelial cell interactions under pathological shear stress, as evidenced by results from a placenta‐on‐a‐chip platform.
Hongli Liu, Yuan Wang, Yanjun Cai, Ruixin Guo, Shunhua Liu, Tingting Chen, Tingting Sun, Ruiheng Huo, Tengwei Liu, Qingfeng Lv, Xietong Wang   +10 more
wiley   +1 more source

Inhibition of interleukin-1β-stimulated collagenase and stromelysin expression in human tendon fibroblasts by epigallocatechin gallate ester [PDF]

, 2004
The medicinal benefits of green tea (Camellia sinensis) consumption have been attributed to bioavailable polyphenols, notably epigallocatechin gallate (EGCG).
Buttle, David J., Corps, Anthony N., Curry, Valerie A., Hazleman, Brian L., Riley, Graham P.   +4 more
core   +1 more source

Machine Learning‐Informed Nano Co‐Assembly Inhibits Fibroblast Activation Protein and Improves Drug Delivery in Fibrotic Tissue

Advanced Materials, EarlyView.
We present SP‐13786 (SP), a fibroblast activation protein (FAP) inhibitor, as a universal excipient for co‐assembling stable drug nanoparticles (SCAN). Assembly mechanism deciphered by molecular dynamics and explainable machine learning, SCAN attenuate fibrosis‐induced stromal barriers, enhances lesional drug accumulation, and improves therapeutic ...
Zehua Liu, Qiang Long, Yihao Liu, Xiuqiao Sun, Baoding Zhang, Binxin Liao, Weibin Wu, Wangxi Hai, Pei Zhang, Wenhua Lian, Yuewen Zhu, Zheng Wang, Caisheng Wu, Xianming Deng, Hélder A. Santos, Xiaofeng Ye   +15 more
wiley   +1 more source

Dingchuan tang essential oil inhibits the production of inflammatory mediators via suppressing the IRAK/NF-κB, IRAK/AP-1, and TBK1/IRF3 pathways in lipopolysaccharide-stimulated RAW264.7 cells

Drug Design, Development and Therapy, 2018
Yi Zhang,1,2,* Hui Guo,1,* Brian Chi-Yan Cheng,1 Tao Su,1 Xiu-Qiong Fu,1 Ting Li,1 Pei-Li Zhu,1 Kai-Wing Tse,1 Si-Yuan Pan,3 Zhi-Ling Yu1,3,4 1Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon
Zhang Y, Guo H, Cheng BCY, Su T, Fu XQ, Li T, Zhu PL, Tse KW, Pan SY, Yu ZL   +9 more
doaj  

Marine Collagen Peptides Promote Cell Proliferation of NIH-3T3 Fibroblasts via NF-κB Signaling Pathway

Molecules, 2019
Marine collagen peptides (MCPs) with the ability to promote cell proliferation and migration were obtained from the skin of Nibea japonica. The purpose of MCPs isolation was an attempt to convert the by-products of the marine product processing industry ...
Fei Yang, Shujie Jin, Yunping Tang
doaj   +1 more source