Results 81 to 90 of about 16,736,389 (319)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Neutrosophic Quadruple Vector Spaces and Their Properties

Mathematics, 2019
In this paper authors for the first time introduce the concept of Neutrosophic Quadruple (NQ) vector spaces and Neutrosophic Quadruple linear algebras and study their properties.
Vasantha Kandasamy W.B., Ilanthenral Kandasamy, Florentin Smarandache   +2 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

i-Vector with sparse representation classification for speaker verification [PDF]

Speech Communication, 2013
Highlights? Tutorial style introduction to sparse representation classification (SRC) and its applications. ? Investigation on SRC for speaker verification using i-vector from the total variability model. ? Comparative study of SRC systems with different sparseness methods and dictionary composition. ?
Jia Min Karen Kua, Julien Epps, Eliathamby Ambikairajah   +2 more
openaire   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

How effective is integrated vector management against malaria and lymphatic filariasis where the diseases are transmitted by the same vector? [PDF]

, 2014
The opportunity to integrate vector management across multiple vector-borne diseases is particularly plausible for malaria and lymphatic filariasis (LF) control where both diseases are transmitted by the same vector.
Stone, C., Chitnis, N., Chitnis, Nakul, Stone, Christopher M., Nakul Chitnis (187823), Lindsay, S.W., Christopher M. Stone (461877), Lindsay, Steve W., Steve W Lindsay, Nakul Chitnis, Christopher M Stone, Steve W. Lindsay (458382)   +11 more
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

A General Representation Theorem for Integrated Vector Autoregressive Processes [PDF]

We study the algebraic structure of an I(d) vector autoregressive process, where d is restricted to be an integer. This is useful to characterize its polynomial cointegrating relations and its moving average representation, that is to prove a version of ...
Massimo Franchi
core  

Malaria transmission dynamics in Makenene, a forest–savanna transition zone, in Centre Region, Cameroon

IJID One Health
Objectives: Makenene, situated in transition zone between forest and savanna, has a high number of malaria cases, and there is little information on the mosquito fauna sustaining the transmission.
Joël Djoufounna, Borel Djiappi-Tchamen, Marie Paul Audrey Mayi, Julius Visnel Foyet, Paulette Ndjeunia-Mbiakop, Steve Joko, Diane Leslie Nkahe, Parfait Awono-Ambene, Christophe Antonio-Nkondjio, Timoléon Tchuinkam, Roland Bamou   +10 more
doaj   +1 more source