Results 101 to 110 of about 24,397,514 (310)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Multidimensional encoding of restricted and anisotropic diffusion by double rotation of the q vector. [PDF]

Magn Reson (Gott), 2023
Jiang H, Svenningsson L, Topgaard D.
europepmc   +1 more source

Vector Spring 2019

, 2019
Table of Contents: Why Antivaxx has Gone Viral (p. 4) -- Cut and Paste (p. 6) -- Scooter Mayhem (p. 8) -- The Automation Dilemma (p. 10) -- Humanitarian Design (p. 12) -- Inclusivity in Engineering (p. 14) -- Undocumented Students (p.
University of Texas at Austin
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

The dyadic Riesz vector I [PDF]

, 2023
We derive a dyadic model operator for the Riesz vector. We show linear lower $L^p$ bounds for $1 < p < \infty$ between this model operator and the Riesz vector, when applied to functions with values in Banach spaces.
Domelevo, Komla, Petermichl, Stefanie
core  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Molecular genetic methods for quality control of inactivated vaccines using a Chikungunya virus model: vaccine strain identification and completeness of virus inactivation

Биопрепараты: Профилактика, диагностика, лечение
INTRODUCTION. The completeness of virus inactivation and the identity of the vaccine strain are essential parameters for the safety and quality of inactivated virus vaccines, which should be controlled during vaccine development and production. Currently,
A. S. Oksanich, T. G. Samartseva, K. V. Kaa, E. V. Otrashevskaia, A. G. Krasko, A. G. Laputina, N. A. Netesova, G. M. Ignatyev   +7 more
doaj   +1 more source

Dengue Incidence and Aedes Vector Collections in Relation to COVID-19 Population Mobility Restrictions. [PDF]

Trop Med Infect Dis, 2022
Surendran SN, Nagulan R, Tharsan A, Sivabalakrishnan K, Ramasamy R.   +4 more
europepmc   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Susceptibility of Amblyomma sculptum, Vector of Rickettsia rickettsii, Ticks from a National Park and an Experimental Farm to Different Synthetic Acaricides. [PDF]

Pathogens, 2023
Cardoso ERN, Carvalho SF, Dias SA, Santos RA, Tavares MA, Neves LC, Paula WVF, Pádua GT, de Lima NJ, Paludo RLDR, Silva IS, Bittencourt RBM, Dos Santos GC, Nascimento FGJ, de Paula LGF, Dantas-Torres F, Monteiro CMO, Krawczak FDS.   +17 more
europepmc   +1 more source