Results 21 to 30 of about 403,056 (242)

Pseudohypoparathyroidism Ia and Hypercalcitoninemia [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2001
Pseudohypoparathyroidism Ia (PHP Ia) is characterized by resistance to PTH and many other stimuli because of deficiency of stimulatory G protein alpha-subunit. To determine the incidence, natural history, and mechanism of C cell dysfunction in PHP, calcitonin assays were performed in six patients with PHP Ia and four with pseudopseudohypoparathyroidism
V, Vlaeminck-Guillem, M, D'herbomez, P, Pigny, A, Fayard, C, Bauters, M, Decoulx, J L, Wémeau   +6 more
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Los usos de la inteligencia artificial en procesos productivos de pequeñas y medianas empresas. Análisis de su implementación y obstáculos

Kera Yvoty
Actualmente, las empresas están adoptando progresivamente estrategias de transformación digital en sus modelos de negocio. Dicha adopción, personificada en la figura de las TIC (Tecnologías de la Información y Comunicación) les está permitiendo ser más ...
Vicente Castelló Andreu
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

A EMERGÊNCIA DO PROCESSO CRIATIVO ASSITIDO POR INTELIGÊNCIA ARTIFICIAL

Revista Projetar
Este artigo é parte integrante de uma pesquisa de mestrado que está sendo conduzida junto ao programa de Pós-Graduação em Eficiência Energética e Sustentabilidade (PPGEES), e investiga a emergência do processo criativo assistido por Inteligência ...
Alex Leone do Espirito Santo, Gilfranco ALVES   +1 more
doaj   +1 more source

L’IA, le brin d’herbe, la caresse et le regard

Interfaces Numériques, 2020
L’IA est souvent présentée comme un modèle devenu un concurrent de l’intelligence humaine. Mais si on la caractérise qu’elle est une manière artificielle de résoudre des problèmes qui requièrent de la part des humains de l’intelligence, rien n’implique ...
Bruno Bachimont
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

La era del sensacionalismo artificial: análisis de titulares en noticias de sucesos generados por ChatGPT

Revista de la Asociación Española de Investigación de la Comunicación
El presente estudio analiza el impacto del modelo de lenguaje de gran escala (LLM) ChatGPT en la redacción periodística. Esta investigación examina titulares de noticias de sucesos generados de manera automatizada por ChatGPT, para identificar posibles ...
Mónica Melero Lázaro, Francisco José García-Ull, Rosa María Rodríguez-Cárcela   +2 more
doaj   +1 more source

Lifelong self-education in a sociotechincal context

Contextos Educativos: Revista de Educación, 2020
Permanent education is a process of self-construction based on the pedagogical principles of educability, educativity and personal autonomy. The process of human construction implies a process of lifelong and lifewide learning and training in order to ...
Gonzalo Vázquez Gómez
doaj   +1 more source