Results 31 to 40 of about 717,375 (275)
Kera YvotyActualmente, las empresas están adoptando progresivamente estrategias de transformación digital en sus modelos de negocio. Dicha adopción, personificada en la figura de las TIC (Tecnologías de la Información y Comunicación) les está permitiendo ser más ...
Vicente Castelló Andreu
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
A EMERGÊNCIA DO PROCESSO CRIATIVO ASSITIDO POR INTELIGÊNCIA ARTIFICIAL
Revista ProjetarEste artigo é parte integrante de uma pesquisa de mestrado que está sendo conduzida junto ao programa de Pós-Graduação em Eficiência Energética e Sustentabilidade (PPGEES), e investiga a emergência do processo criativo assistido por Inteligência ...
Alex Leone do Espirito Santo +1 more
doaj +1 more source
L’IA, le brin d’herbe, la caresse et le regard
Interfaces Numériques, 2020 L’IA est souvent présentée comme un modèle devenu un concurrent de l’intelligence humaine. Mais si on la caractérise qu’elle est une manière artificielle de résoudre des problèmes qui requièrent de la part des humains de l’intelligence, rien n’implique ...
Bruno Bachimont
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
Revista de la Asociación Española de Investigación de la ComunicaciónEl presente estudio analiza el impacto del modelo de lenguaje de gran escala (LLM) ChatGPT en la redacción periodística. Esta investigación examina titulares de noticias de sucesos generados de manera automatizada por ChatGPT, para identificar posibles ...
Mónica Melero Lázaro +2 more
doaj +1 more source
Lifelong self-education in a sociotechincal context
Contextos Educativos: Revista de Educación, 2020 Permanent education is a process of self-construction based on the pedagogical principles of educability, educativity and personal autonomy. The process of human construction implies a process of lifelong and lifewide learning and training in order to ...
Gonzalo Vázquez Gómez
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Revista de la Asociación Española de Investigación de la ComunicaciónLa integración de la inteligencia artificial (IA) en entornos educativos plantea oportunidades y desafíos significativos, especialmente en términos de pensamiento crítico y percepción estudiantil.
Daniel Arrébola Concejero +1 more
doaj +1 more source