Results 41 to 50 of about 717,375 (275)

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Conocimiento, tecnologia y cultura: los tres pilares de Ia innovaci6n en Ia sociedad del conocimiento

, 2011
La innovación, en las sociedades modernas, juega un papel fundamental debido principalmente a sus impactos sabre Ia economfa, los niveles y estilos de vida de Ia gente, sus formas de interrelación y aun sus maneras de entender el mundo y Ia vida ...

core   +2 more sources

Evaluación de ChatGPT como asistente en el proceso de creación de un guion de cortometraje de ficción

Revista de la Asociación Española de Investigación de la Comunicación
El debate en torno a la Inteligencia artificial generativa se encuentra en momento efervescente sea cual sea su ámbito de aplicación.  La industria audiovisual no es ajena a esto y la profesión se debate entre el rechazo y la curiosidad por esta nueva ...
Rodrigo Mesonero Izquierdo
doaj   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Reseña de Inteligencia artificial e incunables poéticos: un modelo de transcripción automática

Revista de Cancioneros Impresos y Manuscritos
Alejada de la ola contra la IA que desató el lanzamiento de ChatGPT en 2022, esta monografía es una muestra paradigmática de los avances que se pueden alcanzar con la adopción de modelos computacionales de IA en el campo de la filología, en general, y de
Katerine Lizet González Bañuelos
doaj   +1 more source

The colicin Ia receptor, Cir, is also the translocator for colicin Ia [PDF]

Molecular Microbiology, 2010
SummaryColicin Ia, a channel‐forming bactericidal protein, uses the outer membrane protein, Cir, as its primary receptor. To kill Escherichia coli, it must cross this membrane. The crystal structure of Ia receptor‐binding domain bound to Cir, a 22‐stranded plugged β‐barrel protein, suggests that the plug does not move.
Karen S, Jakes, Alan, Finkelstein
openaire   +2 more sources

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

Proximité, distance, qualité de lecture

Actes Sémiotiques
Le projet de « lecture distante » (Moretti 2013), par opposition au processus établi de « lecture attentive », a été lancé parallèlement aux humanités numériques et aux possibilités ouvertes par l’analyse des mégadonnées et d’autres méthodes ...
Paul Cobley
doaj   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source