Results 151 to 160 of about 13,087 (187)
Nonhuman IAPP Variants Inhibit Human IAPP Aggregation [PDF]
Protein & Peptide Letters, 2021 Aim: To identify naturally occurring variants of IAPP capable of inhibiting the aggregation of human IAPP and protecting living cells from the toxic effects of human IAPP. Background: The loss of insulin-producing β-cells and the overall progression of type 2 diabetes appears to be linked to the formation of toxic human IAPP (hIAPP, Islet Amyloid ...
Alissa Oakes +9 more
openaire +3 more sources
Levels of retinal IAPP are altered in Alzheimer's disease patients and correlate with vascular changes and hippocampal IAPP levels [PDF]
Neurobiology of Aging, 2018 Islet amyloid polypeptide (IAPP) forms toxic aggregates in the brain of patients with Alzheimer's disease (AD). Whether IAPP also affects the retina in these patients is still unknown.
Nina Schultz, Malin Wennström
exaly +4 more sources
Food intake and meal pattern in IAPP knockout mice with and without infusion of exogenous IAPP [PDF]
Scandinavian Journal of Gastroenterology, 2012 Objective. The current study used islet amyloid polypeptide (IAPP) knockout mice (KO mice) to investigate the physiological role of IAPP in the regulation of food intake (FI). Material and methods. FI and body weight were measured in KO and wild-type (WT)
Urban Arnelo +2 more
exaly +2 more sources
Some of the next articles are maybe not open access.
Characterization and Comparison of Human IAPP to Animal IAPPs
The FASEB Journal, 2020Islet Amyloid Polypeptides (IAPPs), are insoluble amyloids or small oligomers that are notorious for aggregating into deposits that destroy pancreatic β‐islet cells, the primary producers of insulin. The aggregation of the 37‐amino acid polypeptide human islet amyloid polypeptide (hIAPP) seems to play a role in this aggregation and cell death process ...
Jaris Torres +2 more
openaire +1 more source
Apolipoprotein E Interferes with IAPP Aggregation and Protects Pericytes from IAPP-Induced Toxicity [PDF]
Biomolecules, 2020 Apolipoprotein E (ApoE) has become a primary focus of research after the discovery of its strong linkage to Alzheimer’s disease (AD), where the ApoE4 variant is the highest genetic risk factor for this disease.
Nina Schultz +2 more
exaly +2 more sources
IAPP/amylin gene transcriptional control region: evidence for negative regulation [PDF]
FEBS Letters, 1990 Aberrant expression of the islet amyloid polypeptide (IAPP) gene might be involved in the pathogenesis of nun-insulin-dependent diabetes mellitus (NIDDM). Here, we report that IAPP promoter-luciferase constructs revealed tissue-specific activity.
H S Jansz, J W Höppener, C J Lips
exaly +2 more sources
2001 International Conferences on Info-Tech and Info-Net. Proceedings (Cat. No.01EX479), 2001
In this paper, 3 kinds of distribution system (DS) topologies are introduced. Then 3 IAPP protocols available are analyzed and compared from their complexity and robustness. A new IAPP enhancement protocol based on DSC is proposed, and the handover process and query process are described and are proven to have better robustness than previous protocols.
XIAOHUI JIN, JIANDONG LI
openaire +1 more source
In this paper, 3 kinds of distribution system (DS) topologies are introduced. Then 3 IAPP protocols available are analyzed and compared from their complexity and robustness. A new IAPP enhancement protocol based on DSC is proposed, and the handover process and query process are described and are proven to have better robustness than previous protocols.
XIAOHUI JIN, JIANDONG LI
openaire +1 more source
From Peptide Fragments to Whole Protein: Copper(II) Load and Coordination Features of IAPP [PDF]
Chemistry - A European Journal, 2017 The copper-binding features of rat islet amyloid polypeptide (r-IAPP) are herein disclosed through the determination of the stability constants and spectroscopic properties of its copper complex species. To mimic the metal binding sites of the human IAPP
Enrico Rizzarelli +2 more
exaly +2 more sources
The human serum protein C4b-binding protein inhibits pancreatic IAPP-induced inflammasome activation [PDF]
Diabetologia, 2017 Aims/hypothesis: Inflammasome activation and subsequent IL-1β production is a driver of islet pathology in type 2 diabetes. Oligomers, but not mature amyloid fibrils, of human islet amyloid polypeptide (IAPP), which is co-secreted with insulin, trigger ...
Anna Blom +2 more
exaly +2 more sources