Results 51 to 60 of about 151,906 (307)
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
miR-186 induces tetraploidy in arsenic exposed human keratinocytes
Ecotoxicology and Environmental Safety, 2023 Chronic inorganic arsenic (iAs) exposure in drinking water is a global issue affecting >225 million people. Skin is a major target organ for iAs. miRNA dysregulation and chromosomal instability (CIN) are proposed mechanisms of iAs-induced carcinogenesis.
Ana P. Ferragut Cardoso +4 more
doaj +1 more source
Symposium - International Astronomical Union, 1992 Spectral calculations show that a model based on the thermonuclear explosion of a degenerate carbon/oxygen white dwarf provides excellent agreement with observations of Type Ia supernovae. Identification of suitable evolutionary progenitors remains a severe problem. General problems with estimation of supernova rates are outlined and the origin of Type
openaire +1 more source
The colicin Ia receptor, Cir, is also the translocator for colicin Ia [PDF]
Molecular Microbiology, 2010 SummaryColicin Ia, a channel‐forming bactericidal protein, uses the outer membrane protein, Cir, as its primary receptor. To kill Escherichia coli, it must cross this membrane. The crystal structure of Ia receptor‐binding domain bound to Cir, a 22‐stranded plugged β‐barrel protein, suggests that the plug does not move.
Karen S, Jakes, Alan, Finkelstein
openaire +2 more sources
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Archivos de Prevención de Riesgos LaboralesIntroduction: The outbreak of the COVID-19 pandemic put at risk the resilience of healthcare professionals by exposing them to high levels of stress.
Eva Frigola-Capell +10 more
doaj +1 more source
Frontiers in Plant Science, 2016 Orobanche cumana Wallr. (sunflower broomrape) is a holoparasitic weed that infects roots of sunflower in large areas of Europe and Asia. Two distant O. cumana gene pools have been identified in Spain, one in Cuenca province in the Centre and another one ...
Alberto eMartín-Sanz +4 more
doaj +1 more source
Piano di Emergenza IAS CNR Oristano : scheda informativa per il personale [PDF]
, 2020 Scheda informativa per il personale sia CNR che in visita del Piano di Emergenza dell'Istituto per lo studio degli impatti Antropici e Sostenibilità in ambiente marino (IAS) del CNR, Sede Secondaria di Oristano con numero di telefono e indicazioni nell ...
Cordatore, Marcello +2 more
core
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
MiR‐513a promotes human erythroid differentiation by modulating c‐Jun
FEBS Open Bio, EarlyView.During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim +11 more
wiley +1 more source