Alzheimer's &Dementia, Volume 20, Issue 10, Page 7399-7402, October 2024.Abstract A Nature Medicine paper published in January 2024 describes eight cases of iatrogenic Alzheimer's disease in individuals who received cadaveric pituitary‐derived human growth hormone. The paper's conclusions argue for the transmissibility of Alzheimer's disease, which, if true, would create a significant public health crisis.
Avi Nath +4 more
wiley +1 more source
Diagnosis and Management of Cerebral Amyloid Angiopathy:A Scientific Statement from the International CAA Association and the World Stroke Organization [PDF]
Cerebral amyloid angiopathy (CAA) is a well-recognized and challenging disease for neurologists and other clinicians caring for the rapidly aging worldwide population. CAA is a major cause of spontaneous lobar intracerebral hemorrhage (ICH), and can also
Al-Shahi Salman, Rustam +17 more
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Altering Brain Amyloidosis by Intra-Lingual and Extra-Nasal Exposure of Aβ Aggregates [PDF]
, 2022 Extensive experimental and human-derived evidence suggest that misfolded Aβ particles spread similarly to infectious prions. Moreover, peripheral administration of Aβ seeds accelerates brain amyloidosis in both susceptible experimental animals and humans.
Bravo-Alegria, Javiera +6 more
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Cerebral amyloid angiopathy decades after red blood cell transfusions:a report of two cases from a prospective cohort [PDF]
Background and purpose: Patients who underwent red blood cell (RBC) transfusion from donors who later developed multiple spontaneous intracerebral hemorrhages (ICHs) have recently been identified to have increased risk of ICH themselves.
Kaushik, K. +2 more
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Alzheimer's disease neuropathological change three decades after iatrogenic amyloid-β transmission [PDF]
, 2021 Banerjee, G +11 more
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Recent advances in understanding mammalian prion structure [PDF]
, 2019 Prions are lethal pathogens, which cause fatal neurodegenerative diseases in mammals. They are unique infectious agents and are composed of self-propagating multi-chain assemblies of misfolded host-encoded prion protein (PrP).
Terry, Cassandra +1 more
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Pathology of neurodegenerative disease for the general neurologist [PDF]
, 2023 Neurodegeneration refers to progressive dysfunction or loss of selectively vulnerable neurones from brain and spinal cord regions. Despite important advances in fluid and imaging biomarkers, the definitive diagnosis of most neurodegenerative diseases ...
Bezerra Parmera, Jacy +8 more
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Evidence of amyloid-β cerebral amyloid angiopathy transmission through neurosurgery [PDF]
, 2018 Amyloid-β (Aβ) is a peptide deposited in the brain parenchyma in Alzheimer’s disease and in cerebral blood vessels, causing cerebral amyloid angiopathy (CAA).
Barbosa, R +8 more
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The role of prion-like mechanisms in neurodegenerative diseases [PDF]
, 2020 The prototype of transmissible neurodegenerative proteinopathies is prion disease, characterised by aggregation of abnormally folded conformers of the native prion protein.
Brandner, S, Jaunmuktane, Z
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