Potent prion-like behaviors of pathogenic α-synuclein and evaluation of inactivation methods [PDF]
, 2018 The concept that abnormal protein aggregates show prion-like propagation between cells has been considered to explain the onset and progression of many neurodegenerative diseases.
Arai Tetsuaki +5 more
core +2 more sources
Bloody big data : ensuring the health of blood donors and transfused patients with health registers [PDF]
, 2022 Blood transfusion is widely considered a pillar of modern medicine and is one of the most common medical interventions. A transfusion intimately links two persons and their health through the altruism of blood donors.
Zhao, Jingcheng
core +1 more source
Cross currents in protein misfolding disorders: interactions and therapy. [PDF]
, 2009 Protein Misfolding Disorders (PMDs) are a group of diseases characterized by the accumulation of abnormally folded proteins. Despite the wide range of proteins and tissues involved, PMDs share similar molecular and pathogenic mechanisms.
Green, Kristi M +2 more
core +1 more source
Clinical-radiological presentation and natural history of iatrogenic cerebral amyloid angiopathy [PDF]
Background: We aimed to describe neuroimaging features, clinical profiles and long-term outcomes in patients with iatrogenic cerebral amyloid angiopathy (iCAA).Methods: We performed a systematic literature search for case series of iCAA and included ...
Ambler, Gareth +17 more
core +4 more sources
Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA), updates in 2022-2023. Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease:Opportunities for therapy [PDF]
, 2023 This editorial summarizes advances from the Clearance of Interstitial Fluid and Cerebrospinal Fluid (CLIC) group, within the Vascular Professional Interest Area (PIA) of the Alzheimer's Association International Society to Advance Alzheimer's Research ...
Agarwal, N +25 more
core +2 more sources
Journal of Cellular and Molecular Medicine, Volume 29, Issue 23, December 2025.ABSTRACT Endoplasmic reticulum stress (ERS) emerges as a critical pathophysiological nexus in hypertension and related cardiovascular diseases. Chronic ERS activation via the IRE1α‐XBP1, ATF6, and PERK pathways drives vascular endothelial dysfunction (reduced NO bioavailability, increased ET‐1), renin‐angiotensin system (RAS) hyperactivation ...
Xin Ma +6 more
wiley +1 more source
Neurology InternationalThe number of published cases of presumed iatrogenic cerebral amyloid angiopathy (iCAA) due to the transmission of amyloid β during neurosurgery is slowly rising. One of the potential ways of transmission is through a cadaveric dura mater graft (LYODURA)
Maša Fabjan +4 more
doaj +1 more source
Complement in the pathogenesis of Alzheimer's disease [PDF]
, 2017 The emergence of complement as an important player in normal brain development and pathological remodelling has come as a major surprise to most scientists working in neuroscience and almost all those working in complement.
A Alawieh +87 more
core +2 more sources
Diagnosis, treatment, and follow-up of patients with cerebral amyloid angiopathy-related inflammation [PDF]
, 2022 Purpose Cerebral amyloid angiopathy-related inflammation (CAA-ri) is a rare potentially reversible encephalopathy associated with an autoimmune process against proteins deposited in the walls of cortical and leptomeningeal brain vessels.
Battisti, Carla +8 more
core +2 more sources
Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.Abstract Alzheimer's disease (AD) is a neurodegenerative disorder characterized by amyloid‐beta (Aβ) deposition and tau pathology. Although disease‐modifying therapies, such as anti‐Aβ monoclonal antibodies, have been approved, their clinical efficacy remains modest and accompanied by substantial safety concerns. The glymphatic system, which is a brain‐
Jiangwei Ding +3 more
wiley +1 more source