Results 41 to 50 of about 787 (101)
Journal of Cellular and Molecular Medicine, Volume 29, Issue 23, December 2025.ABSTRACT Endoplasmic reticulum stress (ERS) emerges as a critical pathophysiological nexus in hypertension and related cardiovascular diseases. Chronic ERS activation via the IRE1α‐XBP1, ATF6, and PERK pathways drives vascular endothelial dysfunction (reduced NO bioavailability, increased ET‐1), renin‐angiotensin system (RAS) hyperactivation ...
Xin Ma +6 more
wiley +1 more source
Neurology InternationalThe number of published cases of presumed iatrogenic cerebral amyloid angiopathy (iCAA) due to the transmission of amyloid β during neurosurgery is slowly rising. One of the potential ways of transmission is through a cadaveric dura mater graft (LYODURA)
Maša Fabjan +4 more
doaj +1 more source
Amyloid‐β Seeds in Alzheimer's Disease: Research Challenges and Implications
Journal of Neurochemistry, Volume 169, Issue 11, November 2025.The amyloid cascade hypothesis places amyloid‐β (Aβ) at the center of Alzheimer's disease (AD) pathogenesis. Evidence suggests that AD progresses in two phases: an early phase driven by Aβ aggregation and a later phase that progresses at least partly independently of Aβ.
Natalie Beschorner +3 more
wiley +1 more source
Iatrogenic Creutzfeldt-Jakob disease with Amyloid-β pathology: an international study
Acta Neuropathologica Communications, 2018 The presence of pathology related to the deposition of amyloid-β (Aβ) has been recently reported in iatrogenic Creutzfeldt-Jakob disease (iCJD) acquired from inoculation of growth hormone (GH) extracted from human cadaveric pituitary gland or use of ...
Ignazio Cali +22 more
doaj +1 more source
Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.Abstract Alzheimer's disease (AD) is a neurodegenerative disorder characterized by amyloid‐beta (Aβ) deposition and tau pathology. Although disease‐modifying therapies, such as anti‐Aβ monoclonal antibodies, have been approved, their clinical efficacy remains modest and accompanied by substantial safety concerns. The glymphatic system, which is a brain‐
Jiangwei Ding +3 more
wiley +1 more source
Celebrating neuropathology's contributions to Alzheimer's Disease Research Centers
Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.Abstract Our understanding of Alzheimer's disease (AD) and related dementias (ADRD) has grown exponentially, thanks to significant investments by the National Institute on Aging (NIA). This article celebrates the 40th anniversary of the NIA's Alzheimer's Disease Research Centers, highlighting the pivotal role of neuropathology as the bedrock for ...
D. Luke Fischer +45 more
wiley +1 more source
Case Report: Taxifolin for neurosurgery-associated early-onset cerebral amyloid angiopathy
Frontiers in NeurologyCases of iatrogenic cerebral amyloid angiopathy (CAA) have been increasingly reported recently, particularly those associated with neurosurgery. Preclinical studies have shown taxifolin to be promising for treating CAA.
Maxwell C. Y. Choi +8 more
doaj +1 more source
Fecal Impaction: An Unusual Cause of Acute Kidney Injury in a Kidney Transplant Recipient
Case Reports in Transplantation, Volume 2025, Issue 1, 2025.Acute kidney injury (AKI) is common in kidney transplant recipients, and the etiology varies depending on the time since transplantation. We present an uncommon case of AKI from obstructive uropathy 7 years posttransplant in a 47‐year‐old Caucasian male with moderate intellectual disability and end‐stage kidney disease secondary to glomerulonephritis ...
Hafsa Tariq +8 more
wiley +1 more source
Spontaneous and iatrogenic ARIA: Mechanistic insights from CAA‐related inflammation
Alzheimer's &Dementia, Volume 20, Issue S1, December 2024.Abstract ARIA‐E/H (amyloid‐related imaging abnormalities‐Edema/Hemorrhage) is an umbrella term that defines the radiographic appearance of MRI images abnormality during treatments with Aβ‐lowering monoclonal antibodies (mAbs) for Alzheimer’s disease immunotherapy.
Fabrizio Piazza +8 more
wiley +1 more source