Results 41 to 50 of about 757 (98)

Iatrogenic cerebral amyloid angiopathy

Journal of Neurology, Neurosurgery and Psychiatry, 2022
In the last 6 years, following the first pathological description of presumed amyloid-beta (Aβ) transmission in humans (in 2015) and subsequent experimental confirmation (in 2018), clinical cases of iatrogenic cerebral amyloid angiopathy (CAA)-attributed to the transmission of Aβ seeds-have been increasingly recognised and reported.
Banerjee, Gargi, Samra, Kiran, Adams, Matthew E., Jaunmuktane, Zane, Parry-Jones, Adrian Robert; id_orcid 0000-0002-4462-3846, Grieve, Joan, Toma, Ahmed K., Farmer, Simon F., Sylvester, Richard, Houlden, Henry, Rudge, Peter, Mead, Simon, Brandner, Sebastian, Schott, Jonathan M., Collinge, John, Werring, David J.   +15 more
openaire   +1 more source

A case of iatrogenic transmission of vascular Aß40 amyloid [PDF]

Alzheimers Dement
Abstract Background Iatrogenic cerebral amyloid angiopathy (iCAA) has recently been reported in relatively young adults who received cadaveric dural grafts or neurosurgery during childhood. More than 80 cases of iCAA have been reported; however, insufficient detail regarding Aß40 amyloid transmission was provided in these reports.
Kawarabayashi T, Nakamura T, Takatama S, Miyamoto N, Iwai T, Naito I, Sugawara T, Ishizawa K, Hashimoto K, Amari M, Ikeuchi T, Kasahara H, Ikeda Y, Takatama M, Shoji M.   +14 more
europepmc   +2 more sources

Trends and Projections in Hemorrhagic Stroke‐Related Mortality in the United States: A 1968–2030 CDC WONDER Analysis

Brain and Behavior, Volume 16, Issue 4, April 2026.
Longitudinal analysis of U.S. hemorrhagic stroke mortality trends and future projections, stratified by demographic cohorts, geographic regions, and age‐adjusted mortality rates. Abstract Background Hemorrhagic stroke is a devastating cerebrovascular event with high fatality rates and major economic burden, with hypertension as the primary modifiable ...
Shaheer Bin Shafiq, Muhammad Salik Uddin, Muhammad Hasan, Muhammad Junaid Razzak, Muhammad Tahir, Muhammad Ahmed, Ammad Uddin, Eiman Zeeshan, Khubaib Tariq Mansoor, Hasibullah Aminpoor, Saad Ahmed Waqas   +10 more
wiley   +1 more source

Endoplasmic Reticulum Stress: A Novel Target for the Prevention and Treatment of Hypertension and Its Related Diseases

Journal of Cellular and Molecular Medicine, Volume 29, Issue 23, December 2025.
ABSTRACT Endoplasmic reticulum stress (ERS) emerges as a critical pathophysiological nexus in hypertension and related cardiovascular diseases. Chronic ERS activation via the IRE1α‐XBP1, ATF6, and PERK pathways drives vascular endothelial dysfunction (reduced NO bioavailability, increased ET‐1), renin‐angiotensin system (RAS) hyperactivation ...
Xin Ma, Fei Si, Jie Ma, Chuyan Feng, Yingdong Wang, Luosha Wang, Jing Yu   +6 more
wiley   +1 more source

Recurrent Intracerebral Haematomas Due to Amyloid Angyopathy after Lyodura Transplantation in Childhood

Neurology International
The number of published cases of presumed iatrogenic cerebral amyloid angiopathy (iCAA) due to the transmission of amyloid β during neurosurgery is slowly rising. One of the potential ways of transmission is through a cadaveric dura mater graft (LYODURA)
Maša Fabjan, Ana Jurečič, Miha Jerala, Janja Pretnar Oblak, Senta Frol   +4 more
doaj   +1 more source

Iatrogenic Creutzfeldt-Jakob disease with Amyloid-β pathology: an international study

Acta Neuropathologica Communications, 2018
The presence of pathology related to the deposition of amyloid-β (Aβ) has been recently reported in iatrogenic Creutzfeldt-Jakob disease (iCJD) acquired from inoculation of growth hormone (GH) extracted from human cadaveric pituitary gland or use of ...
Ignazio Cali, Mark L. Cohen, Stéphane Haїk, Piero Parchi, Giorgio Giaccone, Steven J. Collins, Diane Kofskey, Han Wang, Catriona A. McLean, Jean-Philippe Brandel, Nicolas Privat, Véronique Sazdovitch, Charles Duyckaerts, Tetsuyuki Kitamoto, Ermias D. Belay, Ryan A. Maddox, Fabrizio Tagliavini, Maurizio Pocchiari, Ellen Leschek, Brian S. Appleby, Jiri G. Safar, Lawrence B. Schonberger, Pierluigi Gambetti   +22 more
doaj   +1 more source

Glymphatic and meningeal lymphatic dysfunction in Alzheimer's disease: Mechanisms and therapeutic perspectives

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract Alzheimer's disease (AD) is a neurodegenerative disorder characterized by amyloid‐beta (Aβ) deposition and tau pathology. Although disease‐modifying therapies, such as anti‐Aβ monoclonal antibodies, have been approved, their clinical efficacy remains modest and accompanied by substantial safety concerns. The glymphatic system, which is a brain‐
Jiangwei Ding, Chengbin Zhao, Xiaoyan Hao, Hongliang Jiao   +3 more
wiley   +1 more source

Celebrating neuropathology's contributions to Alzheimer's Disease Research Centers

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract Our understanding of Alzheimer's disease (AD) and related dementias (ADRD) has grown exponentially, thanks to significant investments by the National Institute on Aging (NIA). This article celebrates the 40th anniversary of the NIA's Alzheimer's Disease Research Centers, highlighting the pivotal role of neuropathology as the bedrock for ...
D. Luke Fischer, Lea T. Grinberg, Jared T. Ahrendsen, Thomas G. Beach, Kevin F. Bieniek, Rudolph J. Castellani, Rati Chkheidze, Inma Cobos, Mark Cohen, John F. Crary, Dennis W. Dickson, Brittany N. Dugger, Sara R. Dunlop, Kurt Farrell, Bernardino Ghetti, Mohammad Haeri, William Harrison, Elizabeth Head, Annie Hiniker, Eric J. Huang, Anita Huttner, Pouya Jamshidi, Alifiya Kapasi, C. Dirk Keene, Julia Kofler, Caitlin S. Latimer, Ann C. McKee, Karin Mente, Michael B. Miller, Thomas J. Montine, Meaghan Morris, Melissa E. Murray, Peter T. Nelson, Kathy L. Newell, Richard J. Perrin, Biswarathan Ramani, R. Ross Reichard, Subhojit Roy, Johannes C. M. Schlachetzki, William W. Seeley, Geidy E. Serrano, Salvatore Spina, Andrew F. Teich, Shih‐Hsiu J. Wang, Thomas Wisniewski, Edward B. Lee   +45 more
wiley   +1 more source

ePoster

European Journal of Neurology, Volume 33, Issue S1, June 2026.
wiley   +2 more sources

Case Report: Taxifolin for neurosurgery-associated early-onset cerebral amyloid angiopathy

Frontiers in Neurology
Cases of iatrogenic cerebral amyloid angiopathy (CAA) have been increasingly reported recently, particularly those associated with neurosurgery. Preclinical studies have shown taxifolin to be promising for treating CAA.
Maxwell C. Y. Choi, Tiffany H. P. Law, Sirong Chen, William S. K. Cheung, Carmen Yim, Oliver K. S. Ng, Lisa W. C. Au, Vincent C. T. Mok, Peter Y. M. Woo   +8 more
doaj   +1 more source