Results 21 to 30 of about 1,151 (123)

A case of iatrogenic transmission of vascular Aß40 amyloid [PDF]

Alzheimers Dement
Abstract Background Iatrogenic cerebral amyloid angiopathy (iCAA) has recently been reported in relatively young adults who received cadaveric dural grafts or neurosurgery during childhood. More than 80 cases of iCAA have been reported; however, insufficient detail regarding Aß40 amyloid transmission was provided in these reports.
Kawarabayashi T, Nakamura T, Takatama S, Miyamoto N, Iwai T, Naito I, Sugawara T, Ishizawa K, Hashimoto K, Amari M, Ikeuchi T, Kasahara H, Ikeda Y, Takatama M, Shoji M.   +14 more
europepmc   +2 more sources

Amyloid-β Seeds in Alzheimer's Disease: Research Challenges and Implications. [PDF]

J Neurochem
The amyloid cascade hypothesis places amyloid‐β (Aβ) at the center of Alzheimer's disease (AD) pathogenesis. Evidence suggests that AD progresses in two phases: an early phase driven by Aβ aggregation and a later phase that progresses at least partly independently of Aβ.
Beschorner N, Xu Y, Jucker M, Ruiz-Riquelme A.   +3 more
europepmc   +2 more sources

Iatrogenic cerebral amyloid angiopathy: more cases to come [PDF]

Frontiers in Neurology
Till Turloff, Ulf Jensen-Kondering
doaj   +2 more sources

Diagnosis, pathomechanisms and therapy of cerebral amyloid angiopathy-related inflammation (CAA-ri) [PDF]

Neurological Research and Practice
Background Research of the past years has refined our perception of cerebral amyloid angiopathy-related inflammation (CAA-ri) as a subacute autoimmune encephalopathy, which is presumably caused by elevated CSF concentrations of anti-amyloid β (Aβ ...
Rebecca M. Seifert, Randolf Klingebiel, Wolf-Rüdiger Schäbitz   +2 more
doaj   +2 more sources

Seed to Bleed: Iatrogenic Cerebral Amyloid Angiopathy [PDF]

Stroke, 2023
Steven M Greenberg, Andreas Charidimou
exaly   +2 more sources

Spontaneous and iatrogenic ARIA: Mechanistic insights from CAA‐related inflammation [PDF]

Alzheimers Dement
Abstract ARIA‐E/H (amyloid‐related imaging abnormalities‐Edema/Hemorrhage) is an umbrella term that defines the radiographic appearance of MRI images abnormality during treatments with Aβ‐lowering monoclonal antibodies (mAbs) for Alzheimer’s disease immunotherapy.
Piazza F, Lucia D, Guzzi F, Pascarella R, DeBernardi E, Antolini L, Basso G, Zedde M.   +7 more
europepmc   +2 more sources

Spontaneous intracerebral haemorrhage associated with early-onset cerebral amyloid angiopathy and Alzheimer’s disease neuropathological changes five decades after cadaveric dura mater graft

Acta Neuropathologica Communications, 2023
Cerebral amyloid angiopathy (CAA) is a small vessel disease, causing spontaneous intracerebral hemorrhage (ICH) in the elderly. It is strongly associated with Alzheimer disease (AD), as most CAA patients show deposition of Aβ—i.e.
Riccardo Milani, Lucio Aniello Mazzeo, Daniela Vismara, Ilaria Salemi, Emanuele Dainese, Emanuela Maderna, Elisa Pellencin, Marcella Catania, Nicole Campanella, Giuseppe Di Fede, Giorgio Giaccone, Andrea Salmaggi   +11 more
doaj   +1 more source

Rare forms of cerebral amyloid angiopathy: pathogenesis, biological and clinical features of CAA-ri and iCAA

Frontiers in Neuroscience, 2023
Thanks to a more widespread knowledge of the disease, and improved diagnostic techniques, the clinical spectrum of cerebral amyloid angiopathy (CAA) is now broad.
Benedetta Storti, Maria Magdalena Gabriel, Maria Magdalena Gabriel, Stefan Sennfält, Isabella Canavero, Nicola Rifino, Laura Gatti, Anna Bersano   +7 more
doaj   +1 more source

CSF and Plasma Biomarkers in Patients With Iatrogenic Cerebral Amyloid Angiopathy [PDF]

Neurology
Giuliana Pollaci, Gemma Gorla, Isabella Canavero   +2 more
exaly   +2 more sources

Potential human transmission of amyloid β pathology: surveillance and risks [PDF]

, 2020
Studies in experimental animals show transmissibility of amyloidogenic proteins associated with prion diseases, Alzheimer's disease, Parkinson's disease, and other neurodegenerative diseases. Although these data raise potential concerns for public health,
Brandner, S, Collinge, J, Compernolle, V, De Strooper, B, Duyckaerts, C, Edgren, G, Hardy, J, Haïk, S, Helmy, A, Ivinson, AJ, Jaunmuktane, Z, Jucker, M, Knight, R, Lalli, G, Lauwers, E, Lemmens, R, Lin, I-C, Love, S, Mead, S, Perry, VH, Pickett, J, Poppy, G, Radford, SE, Rousseau, F, Routledge, C, Schiavo, G, Schymkowitz, J, Selkoe, DJ, Smith, C, Thal, DR, Theys, T, Tiberghien, P, van den Burg, P, Vandekerckhove, P, Walton, C, Zaaijer, HL, Zetterberg, H   +36 more
core   +6 more sources