Results 31 to 40 of about 1,151 (123)

Exogenous Aβ seeds induce Aβ depositions in the blood vessels rather than the brain parenchyma, independently of Aβ strain-specific information

Acta Neuropathologica Communications, 2021
Little is known about the effects of parenchymal or vascular amyloid β peptide (Aβ) deposition in the brain. We hypothesized that Aβ strain-specific information defines whether Aβ deposits on the brain parenchyma or blood vessels.
Tsuyoshi Hamaguchi, Jee Hee Kim, Akane Hasegawa, Ritsuko Goto, Kenji Sakai, Kenjiro Ono, Yoshinori Itoh, Masahito Yamada   +7 more
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Neuroimaging biomarkers of neurodegenerative diseases and dementia [PDF]

, 2013
Neurodegenerative disorders leading to dementia are common diseases that affect many older and some young adults. Neuroimaging methods are important tools for assessing and monitoring pathological brain changes associated with progressive ...
Risacher, Shannon L., Saykin, Andrew J.
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Transmission of amyloid-beta and tau pathologies is associated with cognitive impairments in a primate

Acta Neuropathologica Communications, 2021
Amyloid-β (Aβ) pathology transmission has been described in patients following iatrogenic exposure to compounds contaminated with Aβ proteins. It can induce cerebral Aβ angiopathy resulting in brain hemorrhages and devastating clinical impacts ...
Suzanne Lam, Fanny Petit, Anne-Sophie Hérard, Susana Boluda, Sabiha Eddarkaoui, Martine Guillermier, The Brain Bank Neuro-C. E. B. Neuropathology Network, Luc Buée, Charles Duyckaerts, Stéphane Haïk, Jean-Luc Picq, Marc Dhenain   +11 more
doaj   +1 more source

Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases. [PDF]

, 2019
The gold standard for a definitive diagnosis of Parkinson disease (PD) is the pathologic finding of aggregated α-synuclein into Lewy bodies and for Alzheimer disease (AD) aggregated amyloid into plaques and hyperphosphorylated tau into tangles.
Brundin, P, Cambi, F, Espay, AJ, Fasano, A, Fernandez, HH, Gan-Or, Z, Greenamyre, JT, Josephs, KA, Kauffman, MA, Lang, AE, Leverenz, JB, Litvan, I, Marsili, L, Mata, IF, Merola, A, Morgante, F, Perry, G, Sardi, SP, Savica, R, Schwarzschild, MA, Sherer, T, Simon, DK, Standaert, DG, Tanner, CM, Vizcarra, JA, Yamasaki, TR, Zabetian, CP   +26 more
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Pre-amyloid oligomers budding:a metastatic mechanism of proteotoxicity [PDF]

, 2016
The pathological hallmark of misfolded protein diseases and aging is the accumulation of proteotoxic aggregates. However, the mechanisms of proteotoxicity and the dynamic changes in fiber formation and dissemination remain unclear, preventing a cure ...
BERNINI, FABRIZIO, BORSARI, Marco, BORTOLOTTI, Carlo Augusto, BRIGATTI, Maria Franca, CASTELLINI, Elena, Del Monte, Federica, DI ROCCO, Giulia, Kayed, Rakez, LANCELLOTTI, LIDIA, MALFERRARI, Daniele, PIGNATARO, MARCELLO   +10 more
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Iatrogenic cerebral amyloid angiopathy: an emerging clinical phenomenon [PDF]

, 2022
In the last 6 years, following the first pathological description of presumed amyloid-beta (Aβ) transmission in humans (in 2015) and subsequent experimental confirmation (in 2018), clinical cases of iatrogenic cerebral amyloid angiopathy (CAA)—attributed
Adams, Matthew E, Banerjee, Gargi, Brandner, Sebastian, Collinge, John, Farmer, Simon F, Grieve, Joan, Houlden, Henry, Jaunmuktane, Zane, Mead, Simon, Parry-Jones, Adrian Robert, Rudge, Peter, Samra, Kiran, Schott, Jonathan M, Sylvester, Richard, Toma, Ahmed K, Werring, David J   +15 more
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Deposits of disease-associated alpha-synuclein may be present in the dura mater in Lewy body disorders: implications for potential inadvertent transmission by surgery [PDF]

, 2020
Deposition of alpha-synuclein in the brain is a hallmark of Lewy body disorders. Alpha-synuclein has been considered to show prion-like properties.
Budka, Herbert, Fischer, Peter, Gelpi, Ellen, Hönigschnabl, Selma, Kovacs, Gabor G., Lang, Anthony, Reiner, Angelika, Visanji, Naomi P.   +7 more
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Prion Diseases: A Unique Transmissible Agent or a Model for Neurodegenerative Diseases? [PDF]

, 2021
The accumulation and propagation in the brain of misfolded proteins is a pathological hallmark shared by many neurodegenerative diseases such as Alzheimer’s disease (Aβ and tau), Parkinson’s disease (α-synuclein), and prion disease (prion protein ...
Barria, Marcelo A., Ritchie, Diane L.
core   +2 more sources

Progression of cerebral amyloid angiopathy: a pathophysiological framework [PDF]

, 2023
Cerebral amyloid angiopathy, which is defined by cerebrovascular deposition of amyloid 13, is a common age-related small vessel pathology associated with intracerebral haemorrhage and cognitive impairment. Based on complementary lines of evidence from in
Buchem, M.A. van, Chhatwal, J.P., Etten, E.S. van, Greenberg, S.M., Koemans, E.A., Kozberg, M.G., Martins, R.N., Osch, M.J.P. van, Shirzadi, Z., Smith, E.E., Sohrabi, H.R., Terwindt, G.M., Veluw, S.J. van, Walderveen, M.A.A. van, Wermer, M.J.H., Werring, D.J.   +15 more
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Amyloid-β pathology and cerebral amyloid angiopathy are frequent in iatrogenic Creutzfeldt-Jakob disease after dural grafting

Swiss Medical Weekly, 2016
QUESTIONS UNDER STUDY: Alzheimer-type amyloid-β (Aβ) pathology was reported in brains of individuals developing iatrogenic Creutzfeldt-Jakob disease (iCJD) after treatment with human cadaveric growth hormone, and interpreted as evidence of human ...
Karl Frontzek, Mirjam I. Lutz, Adriano Aguzzi, Gabor G. Kovacs, Herbert Budka   +4 more
doaj   +1 more source