Results 51 to 60 of about 1,151 (123)

Iatrogenic Creutzfeldt-Jakob disease with Amyloid-β pathology: an international study

Acta Neuropathologica Communications, 2018
The presence of pathology related to the deposition of amyloid-β (Aβ) has been recently reported in iatrogenic Creutzfeldt-Jakob disease (iCJD) acquired from inoculation of growth hormone (GH) extracted from human cadaveric pituitary gland or use of ...
Ignazio Cali, Mark L. Cohen, Stéphane Haїk, Piero Parchi, Giorgio Giaccone, Steven J. Collins, Diane Kofskey, Han Wang, Catriona A. McLean, Jean-Philippe Brandel, Nicolas Privat, Véronique Sazdovitch, Charles Duyckaerts, Tetsuyuki Kitamoto, Ermias D. Belay, Ryan A. Maddox, Fabrizio Tagliavini, Maurizio Pocchiari, Ellen Leschek, Brian S. Appleby, Jiri G. Safar, Lawrence B. Schonberger, Pierluigi Gambetti   +22 more
doaj   +1 more source

Celebrating neuropathology's contributions to Alzheimer's Disease Research Centers

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract Our understanding of Alzheimer's disease (AD) and related dementias (ADRD) has grown exponentially, thanks to significant investments by the National Institute on Aging (NIA). This article celebrates the 40th anniversary of the NIA's Alzheimer's Disease Research Centers, highlighting the pivotal role of neuropathology as the bedrock for ...
D. Luke Fischer, Lea T. Grinberg, Jared T. Ahrendsen, Thomas G. Beach, Kevin F. Bieniek, Rudolph J. Castellani, Rati Chkheidze, Inma Cobos, Mark Cohen, John F. Crary, Dennis W. Dickson, Brittany N. Dugger, Sara R. Dunlop, Kurt Farrell, Bernardino Ghetti, Mohammad Haeri, William Harrison, Elizabeth Head, Annie Hiniker, Eric J. Huang, Anita Huttner, Pouya Jamshidi, Alifiya Kapasi, C. Dirk Keene, Julia Kofler, Caitlin S. Latimer, Ann C. McKee, Karin Mente, Michael B. Miller, Thomas J. Montine, Meaghan Morris, Melissa E. Murray, Peter T. Nelson, Kathy L. Newell, Richard J. Perrin, Biswarathan Ramani, R. Ross Reichard, Subhojit Roy, Johannes C. M. Schlachetzki, William W. Seeley, Geidy E. Serrano, Salvatore Spina, Andrew F. Teich, Shih‐Hsiu J. Wang, Thomas Wisniewski, Edward B. Lee   +45 more
wiley   +1 more source

Intracerebral Hemorrhage among Blood Donors and Their Transfusion Recipients [PDF]

, 2023
Importance: Recent reports have suggested that cerebral amyloid angiopathy, a common cause of multiple spontaneous intracerebral hemorrhages (ICHs), may be transmissible through parenteral injection of contaminated cadaveric pituitary hormone in humans ...
Dahlén, T, De Strooper, B, Edgren, G, Erikstrup, C, Hjalgrim, H, Lauwers, E, Lemmens, R, Ostrowski, SR, Pedersen, OB, Rostgaard, K, Zhao, J   +10 more
core  

Amyloid-β accumulation in the CNS in human growth hormone recipients in the UK [PDF]

, 2017
Human-to-human transmission of Creutzfeldt–Jakob disease (CJD) has occurred through medical procedures resulting in iatrogenic CJD (iCJD). One of the commonest causes of iCJD was the use of human pituitary-derived growth hormone (hGH) to treat primary or
Adlard, Peter, Burns, Kimberley, Chinnery, Patrick F., Head, Mark W., Ironside, James W., Jackson, Rosemary J., Keogh, Michael J., Le Grice, Margaret, Lowrie, Suzanne, Peden, Alexander H., Ritchie, Diane L., Wei, Wei, Yull, Helen   +12 more
core   +4 more sources

Case Report: Taxifolin for neurosurgery-associated early-onset cerebral amyloid angiopathy

Frontiers in Neurology
Cases of iatrogenic cerebral amyloid angiopathy (CAA) have been increasingly reported recently, particularly those associated with neurosurgery. Preclinical studies have shown taxifolin to be promising for treating CAA.
Maxwell C. Y. Choi, Tiffany H. P. Law, Sirong Chen, William S. K. Cheung, Carmen Yim, Oliver K. S. Ng, Lisa W. C. Au, Vincent C. T. Mok, Peter Y. M. Woo   +8 more
doaj   +1 more source

Fecal Impaction: An Unusual Cause of Acute Kidney Injury in a Kidney Transplant Recipient

Case Reports in Transplantation, Volume 2025, Issue 1, 2025.
Acute kidney injury (AKI) is common in kidney transplant recipients, and the etiology varies depending on the time since transplantation. We present an uncommon case of AKI from obstructive uropathy 7 years posttransplant in a 47‐year‐old Caucasian male with moderate intellectual disability and end‐stage kidney disease secondary to glomerulonephritis ...
Hafsa Tariq, Madhuri Ramakrishnan, Pablo Portocarrero, Mallika Gupta, Nicholas Herrera, Jeffrey Klein, Aditi Gupta, Diane Cibrik, Richa Sharma   +8 more
wiley   +1 more source

Fatal Iatrogenic Cerebral Amyloid‐Related Encephalitis in a woman treated with lecanemab for Alzheimer’s disease

Alzheimer's &Dementia, Volume 20, Issue S6, December 2024.
Abstract Background We report the case of a 79‐year‐old woman with Alzheimer’s disease who enrolled in a clinical study of lecanemab. After the third, biweekly infusion she suffered a seizure followed by aphasia and progressive encephalopathy.
Elena Solopova
wiley   +1 more source

Severe traumatic brain injury in early adulthood and cerebral amyloid angiopathy [PDF]

Recent research has increasingly recognized a potential link between severe traumatic brain injury (TBI) decades ago and the later development of cerebral amyloid angiopathy (CAA).
Bošnjak, Matic, Frol, Senta, Straus, Lara, Velnar, Tomaž, Zupan, Matija   +4 more
core   +2 more sources

Prion protein monoclonal antibody (PRN100) therapy for Creutzfeldt–Jakob disease: evaluation of a first-in-human treatment programme [PDF]

, 2022
Background: Human prion diseases, including Creutzfeldt–Jakob disease (CJD), are rapidly progressive, invariably fatal neurodegenerative conditions with no effective therapies.
Brandner, S, Campbell, T, Canning, S, Collinge, J, Darwent, L, Ebsworth, N, Hextall, P, Hyare, H, Jaunmuktane, Z, Khalili-Shirazi, A, Libri, V, Linehan, J, Mead, S, Mok, T, Muirhead, N, Nihat, A, Potter, C, Rudge, P, Schmidt, C, Wakeling, M, Williams, B   +20 more
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Aβ plaques [PDF]

, 2020
Aβ plaques are one of the two lesions in the brain that define the neuropathological diagnosis of Alzheimer’s disease. Plaques are highly diverse structures; many of them include massed, fibrillar polymers of the Aβ protein referred to as Aβ-amyloid, but
Walker, Lary C
core   +2 more sources