Results 41 to 50 of about 822 (142)

In vitro activity of ibrexafungerp and comparators against Candida albicans genotypes from vaginal samples and blood cultures [PDF]

Clinical Microbiology and Infection, 2021
Emergence of azole resistance may contribute to recurrences of vulvovaginal candidiasis. Thus, new drugs are needed to improve the therapeutic options. We studied the in vitro activity of ibrexafungerp and comparators against Candida albicans isolates from vaginal samples and blood cultures.
Mesquida, Aina, Vicente, Teresa, Reigadas, Elena, Palomo, María, Sánchez-Carrillo, Carlos, Muñoz, Patricia, Guinea, Jesús, Escribano, Pilar   +7 more
openaire   +3 more sources

Synthesis and Application of Bioactive N‐Functionalized Aziridines

Angewandte Chemie, Volume 137, Issue 44, October 27, 2025.
This review discusses modern synthetic methods for the preparation of aziridine‐containing small molecules, including biocatalytic, electrocatalytic, and photocatalytic strategies. We highlight the compatibility of various synthetic methods with control of the exocyclic N‐substituent.
Hao Tan, Samya Samanta, Nan Qiu, Alexander Adibekian, David C. Powers   +4 more
wiley   +2 more sources

Novel antifungal agents in clinical trials [version 2; peer review: 2 approved]

F1000Research, 2022
Invasive fungal diseases due to resistant yeasts and molds are an important and increasing public health threat, likely due to a growing population of immunosuppressed hosts, increases in antifungal resistance, and improvements in laboratory diagnostics.
Samantha E. Jacobs, Panagiotis Zagaliotis, Thomas J. Walsh   +2 more
doaj   +1 more source

Fungal Cell Wall: Emerging Antifungals and Drug Resistance

Frontiers in Microbiology, 2019
The cell wall is an essential component in fungal homeostasis. The lack of a covering wall in human cells makes this component an attractive target for antifungal development. The host environment and antifungal stress can lead to cell wall modifications
Soraia L. Lima, Arnaldo L. Colombo, João N. de Almeida Junior   +2 more
doaj   +1 more source

Probiotic‐based strategies in vulvovaginal candidiasis management: A comprehensive review of mechanisms and future directions

Interdisciplinary Medicine, Volume 4, Issue 3, May 2026.
This review focuses on vulvovaginal candidiasis (VVC), examining its epidemiology, the pathogenesis of Candida albicans, and its relationships with vaginal microbiota. It comprehensively reviews probiotic‐based management strategies and their mechanisms of action, and concludes by discussing current limitations, challenges and future research ...
Tong Chen, Yuwei Wu, Ya Chen, Ying Li, Hui Zhao, Lei Wu, He Gao, Tong Jiang, Xiaohong Wang, Moutong Chen, Jumei Zhang, Xinqiang Xie, Tingting Liang, Qingping Wu   +13 more
wiley   +1 more source

Pharmacodynamics, Mechanisms of Action and Resistance, and Spectrum of Activity of New Antifungal Agents

Journal of Fungi, 2022
Several new antifungals are currently in late-stage development, including those with novel pharmacodynamics/mechanisms of action that represent new antifungal classes (manogepix, olorofim, ATI-2307, GR-2397). Others include new agents within established
Nathan P. Wiederhold
doaj   +1 more source

Targeting Staphylococcus aureus Biofilms Through Aurisin Derivatives From Neonothopanus nambi of African Origin

Chemistry &Biodiversity, Volume 23, Issue 2, February 2026.
This study describes the isolation and characterization of potent bioactive compounds from the fungal strain Neonothopanus nambi, followed by structural elucidation. The compounds shown are dimeric aristolane‐type sesquiterpenoids, identified as aurisins D (1) and B (2).
Syeda J. Khalid, Njogu M. Kimani, Yuanyuyue Huang, Mathias Müsken, Jan‐Peer Wennrich, Jonas Bentrup, Miroslav Kolařík, Josphat Clemet Matasyoh, Hedda Schrey   +8 more
wiley   +1 more source

Epidemiology and Outcomes of Sporotrichosis: A Descriptive Real‐World Analysis From a Global Cohort

Mycoses, Volume 69, Issue 2, February 2026.
ABSTRACT Background Sporotrichosis is a dimorphic fungal infection of increasing global relevance. Although usually cutaneous or lymphocutaneous, disseminated disease occurs in immunocompromised hosts. Large‐scale data on its epidemiology, treatment and outcomes remain limited. Objectives To characterise the clinical features, comorbidities, antifungal
Samantha Schapiro, Nicholas Pulciano, Julian Galindo‐Ramirez, Nicholas Rau, Jose Tuells, Nelson Iván Agudelo Higuita, George R. Thompson III, Daniel B. Chastain, Andrés F. Henao‐Martínez   +8 more
wiley   +1 more source

Engineered Fusion Enzyme‐Mediated Non‐Consecutive Cyclization‐Glycosylation Enables Heterologous Synthesis of Antifungal Enfumafungin

Advanced Science, Volume 12, Issue 44, November 27, 2025.
The artificial biosynthetic pathway potentially involved in biosynthesis of enfumafungin is first reconstructed in an optimized Aspergillus oryzae chassis with the increased site‐specific integration efficiency and shortened time for marker recycling, which requires an artificial fusion enzyme EfuA(TC)FsoA(GT).
Yaohui Gao, Jianming Lv, Yue Zhong, Zhiqin Cao, Rui Luo, Yue Qi, Gaoqian Wang, Shaoyang Li, Guodong Chen, Dan Hu, Hao Gao, Xinsheng Yao   +11 more
wiley   +1 more source

Novel Therapeutic Approaches to Invasive Candidiasis: Considerations for the Clinician

Infection and Drug Resistance, 2023
Frederic Lamoth1,2 1Infectious Diseases Service, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; 2Institute of Microbiology, Department of Laboratory Medicine and Pathology, Lausanne University ...
Lamoth F
doaj