Results 61 to 70 of about 822 (142)
Aspiring Antifungals: Review of Current Antifungal Pipeline Developments
Journal of Fungi, 2020 Invasive fungal infections are associated with significant morbidity and mortality, and their management is restricted to a variety of agents from five established classes of antifungal medication.
Thomas J. Gintjee +2 more
doaj +1 more source
Effect of Star Topology Versus Linear Polymers on Antifungal Activity and Mammalian Cell Toxicity
Macromolecular Bioscience, Volume 24, Issue 5, May 2024.Synthetic polymers inspired by natural antimicrobial peptides have shown promise for the treatment of fungal infections. The present study compares linear to star‐like topology of amphiphilic, positively charged polymers. A low‐Xn 3‐arm polymer shows favourable activity against Candida spp. and biocompatibility with fibroblasts.
Sebastian Schaefer +4 more
wiley +1 more source
Recurrent Vulvovaginal Candidiasis: Risk, Prevention and QoL (2020–2026)
Microbiology ResearchRecurrent vulvovaginal candidiasis (RVVC), commonly defined as ≥3 symptomatic episodes per year, affects an estimated 138 million women worldwide. This structured narrative review (PubMed/MEDLINE and open-indexed sources, January 2020–July 2026, as well ...
Sonja M. Novak +5 more
doaj +1 more source
What is the role of microbial biotechnology and genetic engineering in medicine?
MicrobiologyOpen, Volume 13, Issue 2, April 2024.Microbial biotechnology, the technological application of microorganisms, has been instrumental in producing significant natural bioactive products. These include antibiotics, antifungals, anticancer drugs, antiparasitics, antivirals, immunosuppressants, toxoid vaccines, and therapeutic enzymes.
Fernando Santos‐Beneit
wiley +1 more source
Exploring the Depths of Cryptic Aspergillosis: Species Variability, Clinical Spectrum, Diagnostic Quandaries and Therapeutic Options [PDF]
Journal of Clinical and Diagnostic ResearchCryptic aspergillosis, characterised by infections caused by non classical Aspergillus species, presents unique challenges in clinical management due to species variability, diverse clinical manifestations, diagnostic complexities, and limited treatment ...
Almas Fathima Upaisal +1 more
doaj +1 more source
New and emerging options for management of invasive fungal diseases in paediatric patients
Mycoses, Volume 67, Issue 1, January 2024.Abstract Invasive fungal diseases (IFDs) play an important role in the supportive care of paediatric patients with acute leukaemia and those undergoing allogeneic haematopoietic cell transplantation, and they are associated with significantly decreased overall survival rates in affected individuals.
Andreas H. Groll +3 more
wiley +1 more source
Microbiology SpectrumAspergillus fumigatus is the primary etiological agent of aspergillosis. Here, we show that the host defense peptide mimetic brilacidin (BRI) can potentiate ibrexafungerp (IBX) against clinical isolates of A. fumigatus.
Thaila Fernanda dos Reis +4 more
doaj +1 more source
Severe hypercalcemia as a result of disseminated Candida krusei infection
International Journal of Infectious DiseasesCandida krusei disseminated infection is a rare complication of protracted neutropenia. Herein, we report a case of a 31-year-old male with relapsed acute myeloid leukemia who developed Candida krusei fungemia with cutaneous, ocular, splenic, renal, bone
Amenah Alghamdi +9 more
doaj +1 more source
Ibrexafungerp is efficacious in a neutropenic murine model of pulmonary mucormycosis as monotherapy and combined with liposomal amphotericin B. [PDF]
Antimicrob Agents ChemotherABSTRACT Ibrexafungerp (formerly SCY-078) is the first member of the triterpenoid class that prevents the synthesis of the fungal cell wall polymer β-(1,3)-D-glucan by inhibiting the enzyme glucan synthase. We evaluated the in vivo efficacy of ibrexafungerp against pulmonary
Gebremariam T +8 more
europepmc +5 more sources