Results 81 to 90 of about 1,203 (200)

Repositioning Antimicrobial Peptides Against WHO‐Priority Fungi

Advanced Science, Volume 12, Issue 37, October 6, 2025.
The growing burden of drug‐resistant fungal infections, driven by pathogens such as Candida auris, Cryptococcus neoformans, and Aspergillus fumigatus, underscores the urgent need for novel antifungal therapies. This review explores antimicrobial peptides as promising agents with membrane‐disruptive activity, immunomodulatory properties, and delivery ...
Cesar Augusto Roque‐Borda, Kaila Petronila Medina‐Alarcón, João Paulo Soler Gonçalves Pereira, Thais Cristina dos Anjos Sevilhano, Brigitte Aguilar‐Morón, Fernando Díaz‐Cárdenas, Lucas Silva da Cruz, Francisco Humberto Xavier‐Júnior, Eduardo Festozo Vicente, João Perdigão, Beatriz G. de la Torre, Fernando Albericio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

Guideline adherence and survival of patients with candidaemia in Europe:results from the ECMM Candida III multinational European observational cohort study [PDF]

, 2023
Background: The European Confederation of Medical Mycology (ECMM) collected data on epidemiology, risk factors, treatment, and outcomes of patients with culture-proven candidaemia across Europe to assess how adherence to guideline recommendations is ...

core   +1 more source

Virulence and resistance factors of Nakaseomyces glabratus (formerly known as Candida glabrata) in Europe: A systematic review

Journal of the European Academy of Dermatology and Venereology, Volume 39, Issue 2, Page 377-388, February 2025.
Nakaseomyces glabratus (formerly known as Candida glabrata) is an endogenous opportunistic pathogen that causes various clinical manifestations, ranging from mucocutaneous overgrowth to bloodstream infections. This review aims to summarize the biology, epidemiology and pathology of N.
Carmen Rodríguez‐Cerdeira, Rodolfo Pinto‐Almazán, Ditte M. L. Saunte, R. Hay, Jacek C. Szepietowski, Gabriela Moreno‐Coutiño, Mihael Skerlev, Asja Prohic, Erick Martínez‐Herrera   +8 more
wiley   +1 more source

Antifungal Therapy and Probiotics in Women's Health - A Comprehensive Review [PDF]

Candida-induced infections affect millions of women around the world. Therefore, the purpose of this review is to provide a comprehensive analysis of the role of antifungal therapy and probiotics in managing one such infection, vulvovaginal candidiasis ...
Amangeldi, Alma, Baimakhanova, Baiken, Baimakhanova, Gul, Balgimbayeva, Asya, Berezin, Vladimir, Bogoyavlenskiy, Andrey, Kistaubayeva, Aida, Lakh, Olga, Mamirova, Aigerim, Omirbekova, Anel, Orazymbet, Saltanat, Sadanov, Amankeldi, Shorabaev, Erik, Trenozhnikova, Lyudmila, Turlybaeva, Zere   +14 more
core   +2 more sources

Enhancing Flucytosine Anticandidal Activity Using PEGylated Squalene Nanocarrier

ChemMedChem, Volume 20, Issue 1, January 2, 2025.
Our study focused on improving the effectiveness of the antifungal drug 5‐fluorocytosine (5FC) by loading it in micellar structures formed by PEGylated squalene copolymer. The obtained results for 5FC‐loaded micelles showed in vitro prolonged release under physiological conditions and improved in vitro antifungal activity without cytotoxicity for ...
Bogdan‐Florin Craciun, Irina Rosca, Dragos Peptanariu, Mariana Pinteala   +3 more
wiley   +1 more source

Aspiring Antifungals: Review of Current Antifungal Pipeline Developments

Journal of Fungi, 2020
Invasive fungal infections are associated with significant morbidity and mortality, and their management is restricted to a variety of agents from five established classes of antifungal medication.
Thomas J. Gintjee, Monica A. Donnelley, George R. Thompson   +2 more
doaj   +1 more source

Fungal lung disease. [PDF]

Fungal lung disease encompasses a wide spectrum of organisms and associated clinical conditions, presenting a significant global health challenge. The type and severity of disease are determined by underlying host immunity and infecting fungal strain ...
Agarwal, Ritesh, Chotirmall, Sanjay, Delhaes, Laurence, Hage, Chadi, Jaggi, Tavleen, Langelier, Charles, Lydon, Emily, Shah, Anand, Tiew, Pei, Waterer, Grant   +9 more
core   +1 more source

Epidemiological Characterization of Clinical Fungal Isolates from Pauls Stradins Clinical University Hospital, Latvia: : A 4-year Surveillance Report [PDF]

, 2021
Funding Information: The authors are extremely grateful of the management of Pauls Stradin? Clinical University Hospital (PSCUH) and the supporting hospital and laboratory staff for their support in the present study.
Jain, Nityanand, Jansone, Inese, Meisters, Jānis, Obidenova, Tatjana, Reinis, Aigars, Straupmane, Dagnija, Sīmanis, Raimonds   +6 more
core   +1 more source

Hybrid Nanoparticles Dual‐Loaded With Curcumin and Benzydamine Hydrochloride for the Treatment of Vulvovaginal Candidiasis: From Development to Biological Application In Vitro and In Vivo

Advanced Therapeutics, Volume 8, Issue 1, January 2025.
This study offers new possibilities for the development of silica‐based hybrid nanoparticles by microfluidics and highlights the potential combination of curcumin and benzydamine hydrochloride for the treatment of vulvovaginal candidiasis. This disease is a public health challenge due to its reports of high incidence, recurrences and resistance to ...
Gabriela C. Carvalho, Maria Nolasco Viseu Domingues, Gabriel Davi Marena, Ermei Mäkilä, Jiachen Li, Gésinda Geertsema‐Doornbusch, Cleverton Roberto de Andrade, Marc C. A. Stuart, Mohammad‐Ali Shahbazi, Ione Corrêa, Brandon W. Peterson, Jarno Salonen, Helena F. Florindo, Taís Maria Bauab, Marlus Chorilli, Hélder A. Santos   +15 more
wiley   +1 more source

Candida Auris Features and its Treatment: Global Emergency [PDF]

Fungal pathogen Candida auris was identified in 2009, in Japan. Currently, it is identified in 5 continents, in more than 40 countries. Therefore, it is nowadays defined as critical priority pathogen.
Durán, Nelson, Fávaro, Wagner J, Nakazato, Gerson   +2 more
core   +2 more sources