What is the role of microbial biotechnology and genetic engineering in medicine?
MicrobiologyOpen, Volume 13, Issue 2, April 2024.Microbial biotechnology, the technological application of microorganisms, has been instrumental in producing significant natural bioactive products. These include antibiotics, antifungals, anticancer drugs, antiparasitics, antivirals, immunosuppressants, toxoid vaccines, and therapeutic enzymes.
Fernando Santos‐Beneit
wiley +1 more source
New and emerging options for management of invasive fungal diseases in paediatric patients
Mycoses, Volume 67, Issue 1, January 2024.Abstract Invasive fungal diseases (IFDs) play an important role in the supportive care of paediatric patients with acute leukaemia and those undergoing allogeneic haematopoietic cell transplantation, and they are associated with significantly decreased overall survival rates in affected individuals.
Andreas H. Groll +3 more
wiley +1 more source
1248. Efficacy and Safety of Oral Ibrexafungerp in 41 Patients with Refractory Fungal Diseases, Interim Analysis of a Phase 3 Open-label Study (FURI) [PDF]
, 2020 Barbara D. Alexander +21 more
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Epidemiology of Invasive Candidiasis. [PDF]
Invasive candidiasis (IC) is an increasingly prevalent, costly, and potentially fatal infection brought on by the opportunistic yeast, Candida. Previously, IC has predominantly been caused by C. albicans which is often drug susceptible.
Bays, Derek +8 more
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992. Oral Ibrexafungerp Outcomes in Patients with Oropharyngeal and Esophageal Candidiasis from an Interim Analysis of a Phase 3 Open-label Study (FURI) [PDF]
, 2021 José A. Vázquez +21 more
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Severe hypercalcemia as a result of disseminated Candida krusei infection
International Journal of Infectious DiseasesCandida krusei disseminated infection is a rare complication of protracted neutropenia. Herein, we report a case of a 31-year-old male with relapsed acute myeloid leukemia who developed Candida krusei fungemia with cutaneous, ocular, splenic, renal, bone
Amenah Alghamdi +9 more
doaj +1 more source
Pharmacokinetic evaluation of ibrexafungerp for the treatment of vulvovaginal candidiasis and beyond
Expert Opinion on Drug Metabolism & ToxicologyIbrexafungerp is a new triterpenoid antifungal agent with activity against a variety of fungal species, including Aspergillus spp. and echinocandin-resistant Candida spp.This evaluation will summarize currently available clinical evidence on the use of ibrexafungerp in the treatment/prevention of vulvovaginal candidiasis (VVC) and detail the mechanism ...
Gage M, Dixon +2 more
openaire +2 more sources
Diagnostic approach of Fungal Pathogens associated with Nosocomial Infections [PDF]
Background: Hospital-acquired fungal infections continue to increase their concern levels in critically ill patients who receive treatment within intensive care units.
Surabhi Sharma, Dr Umar Farooq , Dr. Sudhir Singh and Dr. Vasundhara Sharma
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Clinical Recommendations for Managing Genitourinary Adverse Effects in Patients Treated with SGLT-2 Inhibitors: A Multidisciplinary Expert Consensus [PDF]
Background: SGLT-2 inhibitors (SGLT-2is) are considered to be a first-line treatment for common conditions like type 2 diabetes, chronic kidney disease, and heart failure due to their proven ability to reduce cardiovascular and renal morbidity and ...
Castro-Conde, Almudena +4 more
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Candidíase Vulvovaginal Recorrente: Estratégias Terapêuticas e Manejo Clínico [PDF]
RESUMO A candidíase vulvovaginal recorrente (CVVR) é uma condição clínica complexa, caracterizada por múltiplos episódios sintomáticos anuais, com impacto significativo na qualidade de vida das pacientes. Este artigo analisa as estratégias terapêuticas e
BARROS DE MACEDO, RYAN RAFAEL +11 more
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