Results 111 to 120 of about 1,203 (200)

The GPCR antagonist PPTN synergizes with caspofungin providing increased fungicidal activity against Aspergillus fumigatus

Microbiology Spectrum
Fungal pathogens pose a serious threat to human health, with Candida and Aspergillus spp. representing some of the most significant opportunistic invaders.
Thaila Fernanda dos Reis, Endrews Delbaje, Camila Figueiredo Pinzan, Rafael Bastos, Suzanne Ackloo, Sara Fallah, Bradley Laflamme, Nicole Robbins, Leah E. Cowen, Gustavo H. Goldman   +9 more
doaj   +1 more source

Towards covalent inhibition of phosphoglucomutase in Aspergillus fumigatus [PDF]

, 2023
Kowalski, Bartosz
core   +1 more source

Fungal endocarditis: microbial insights, diagnostic and therapeutic challenges in the modern era [PDF]

Exploration of Cardiology
Fungal endocarditis (FE) is still an uncommon but devastating infection, especially when immunosuppression, prosthetic valve surgery, or prolonged health care is involved.
Sudeep Edpuganti
doaj   +1 more source

New Ground in Antifungal Discovery and Therapy for Invasive Fungal Infections: Innovations, Challenges, and Future Directions

Journal of Fungi
This review explores current advancements and challenges in antifungal therapies amid rising fungal infections, particularly in immunocompromised patients.
Gustavo A. Niño-Vega, Leonardo Padró-Villegas, Everardo López-Romero   +2 more
doaj   +1 more source

Antifungal Agents in the 21st Century: Advances, Challenges, and Future Perspectives

Infectious Disease Reports
Invasive fungal infections (IFIs) represent a growing global health threat, particularly for immunocompromised populations, with mortality exceeding 1.5 million deaths annually.
Francesco Branda, Nicola Petrosillo, Giancarlo Ceccarelli, Marta Giovanetti, Andrea De Vito, Giordano Madeddu, Fabio Scarpa, Massimo Ciccozzi   +7 more
doaj   +1 more source

A phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy of once monthly oral ibrexafungerp for prevention of recurrent vulvovaginal candidiasis (VVC) [PDF]

, 2023
O Goje, N Azie, King T, D Angulo
openalex   +1 more source

Ibrexafungerp Citrate

American Journal of Health-System Pharmacy, 2021
openaire   +2 more sources

Colistin enhances caspofungin antifungal efficacy against Aspergillus fumigatus by modulating calcium homeostasis and stress responses

Nature Communications
Fungal infections cause more than 2.5 million deaths a year. Due to emerging antifungal drug resistance, novel strategies are urgently needed to combat life-threatening fungal diseases. Here, by screening a collection of 5297 compounds derived from three
Laura Cristina García Carnero, Xingyue Li, Patrícia Alves de Castro, Camila Figueiredo Pinzan, Jonatas Erick Maimoni Campanella, Iran Malavazi, Mami Yoshimura, Luis Alberto Vega Isuhuaylas, Yoko Yashiroda, Charles Boone, Nir Osherov, Sara Fallah, Taylor Davie, Nicole Robbins, Leah Cowen, Ling Lu, Thaila Fernanda dos Reis, Gustavo H. Goldman   +17 more
doaj   +1 more source

Intravaginal cooling provides symptom relief in women with vulvovaginal candidiasis and reduces immunopathology in an accompanying mouse model [PDF]

BACKGROUND: Vulvovaginal candidiasis (VVC), caused primarily by Candida albicans, is currently treated with either prescription or over-the-counter antifungal drugs, often with variable efficacy and relapses.
Fidel, Paul L, Langdon, Kimberly, Noverr, Mairi C, Swor, Michael, Yano, Junko   +4 more
core   +2 more sources

Structural-guided identification of two modulators of β−1,3-glucan synthase FKS1

Nature Communications
FKS1 is a β−1,3-glucan synthase critical for fungal cell wall formation and a target for antifungal drugs such as echinocandin and ibrexafungerp. However, the mechanisms regulating FKS1 activity remain largely unknown.
Jialu Li, Jian Li, Angqi Zhu, Xinli Dai, Juxiu Liu, Huayi Liu, Zhili Xia, Yuefan Dong, Wenyu Qian, Lunzhi Dai, Li Guo, Chuangye Yan, Dong Deng, Yunzi Luo, Xiang Wang   +14 more
doaj   +1 more source