Results 71 to 80 of about 822 (142)

Ibrexafungerp: A Novel Oral Triterpenoid Antifungal

Indian Dermatology Online Journal, 2023
Francis, Deepa, Rajiv, Shwetha V., George, Mamatha   +2 more
openaire   +2 more sources

The GPCR antagonist PPTN synergizes with caspofungin providing increased fungicidal activity against Aspergillus fumigatus

Microbiology Spectrum
Fungal pathogens pose a serious threat to human health, with Candida and Aspergillus spp. representing some of the most significant opportunistic invaders.
Thaila Fernanda dos Reis, Endrews Delbaje, Camila Figueiredo Pinzan, Rafael Bastos, Suzanne Ackloo, Sara Fallah, Bradley Laflamme, Nicole Robbins, Leah E. Cowen, Gustavo H. Goldman   +9 more
doaj   +1 more source

In-vitro and In-silico Investigations of Recent and Traditional Antifungal Agents as Inhibitors of Fungal Chitin Synthesis

BioResources
Invasive fungal infections demand novel approaches targeting cell wall components, particularly poly(β)-(1→4)-(N-acetyl-D-glucosamine) (chitin) and β-glucan.
Samy Selim, Mohammed Ibrahim Alghonaim, Sulaiman A. Alsalamah, Shaza N. Alkhatib, Sahar Abdulaziz Alshareef, Mohammed S. Almuhayawi, Hattan S. Gattan, Mohammed H. Alruhaili   +7 more
doaj  

New Ground in Antifungal Discovery and Therapy for Invasive Fungal Infections: Innovations, Challenges, and Future Directions

Journal of Fungi
This review explores current advancements and challenges in antifungal therapies amid rising fungal infections, particularly in immunocompromised patients.
Gustavo A. Niño-Vega, Leonardo Padró-Villegas, Everardo López-Romero   +2 more
doaj   +1 more source

Antifungal Agents in the 21st Century: Advances, Challenges, and Future Perspectives

Infectious Disease Reports
Invasive fungal infections (IFIs) represent a growing global health threat, particularly for immunocompromised populations, with mortality exceeding 1.5 million deaths annually.
Francesco Branda, Nicola Petrosillo, Giancarlo Ceccarelli, Marta Giovanetti, Andrea De Vito, Giordano Madeddu, Fabio Scarpa, Massimo Ciccozzi   +7 more
doaj   +1 more source

Structural-guided identification of two modulators of β−1,3-glucan synthase FKS1

Nature Communications
FKS1 is a β−1,3-glucan synthase critical for fungal cell wall formation and a target for antifungal drugs such as echinocandin and ibrexafungerp. However, the mechanisms regulating FKS1 activity remain largely unknown.
Jialu Li, Jian Li, Angqi Zhu, Xinli Dai, Juxiu Liu, Huayi Liu, Zhili Xia, Yuefan Dong, Wenyu Qian, Lunzhi Dai, Li Guo, Chuangye Yan, Dong Deng, Yunzi Luo, Xiang Wang   +14 more
doaj   +1 more source

Colistin enhances caspofungin antifungal efficacy against Aspergillus fumigatus by modulating calcium homeostasis and stress responses

Nature Communications
Fungal infections cause more than 2.5 million deaths a year. Due to emerging antifungal drug resistance, novel strategies are urgently needed to combat life-threatening fungal diseases. Here, by screening a collection of 5297 compounds derived from three
Laura Cristina García Carnero, Xingyue Li, Patrícia Alves de Castro, Camila Figueiredo Pinzan, Jonatas Erick Maimoni Campanella, Iran Malavazi, Mami Yoshimura, Luis Alberto Vega Isuhuaylas, Yoko Yashiroda, Charles Boone, Nir Osherov, Sara Fallah, Taylor Davie, Nicole Robbins, Leah Cowen, Ling Lu, Thaila Fernanda dos Reis, Gustavo H. Goldman   +17 more
doaj   +1 more source

Synergistic Liposomal Delivery of Ibrexafungerp Citrate and Marine-Sourced Silver Nanoparticles for Effective Management of Vulvovaginal Candidiasis

Journal of Functional Biomaterials
Background: Increasing antifungal resistance, poor mucosal retention, and systemic side effects limit the effectiveness of currently available drugs. This study explores a novel topical nanotherapeutic approach for the targeted treatment of vulvovaginal ...
Pottabathula Shyam Sundar, Uday Kumar S. Patil, Thombre Pooja Sarjerao, Somnath D. Bhinge, Sunil T. Galatage, Unnam Sambamoorthy, Rahul J. Kadam, Viswas Raja Solomon, Arehalli S. Manjappa   +8 more
doaj   +1 more source

Ibrexafungerp [PDF]

, 2020
openaire   +1 more source

Epidemiology, Diagnostics and Therapy of Vulvovaginal Fungal Infections

Pathogens
Vulvovaginal candidiasis (VVC) is one of the most common superficial fungal infections affecting women. A particularly challenging issue is the treatment of recurrent vulvovaginal candidiasis (RVVC)—defined as ≥4 episodes of VVC within 12 months—which ...
Magdalena Frej-Mądrzak, Agnieszka Jama-Kmiecik, Aleksandra Górzyńska, Nikola Wahdan, Urszula Nawrot   +4 more
doaj   +1 more source