Results 221 to 230 of about 85,965 (264)

Role of ICAM-1 in antigen presentation demonstrated by ICAM-1 defective mutants.

The Journal of Immunology, 1990
Abstract We report a methodology for selecting APC with mutations that have impaired their ability to present Ag to T cells. A20 B lymphoblastoid cells were mutagenized and then repeatedly cocultured with murine T-T hybridomas in the presence of specific Ag.
L H, Dang, M T, Michalek, F, Takei, B, Benaceraff, K L, Rock   +4 more
openaire   +2 more sources

Heterogeneity of ICAM‐1 expression, and cytokine regulation of ICAM‐1 expression, in skin and oral keratinocytes

Journal of Oral Pathology & Medicine, 1996
Differences in expression of intercellular adhesion molecule‐1 (ICAM‐1) and ICAM‐1 mRNA levels were studied in cultured skin and oral keratinocytes before and after stimulation with different pro‐inflammatory cytokines. Basal expression of ICAM‐1 was undetectable on skin keratinocytes but oral keratinocytes expressed ICAM‐1 at high levels.
J, Li, D L, Mahiouz, P M, Farthing, D O, Haskard, M H, Thornhill   +4 more
openaire   +2 more sources

Circulating forms of intercellular adhesion molecule (ICAM)-1 in mice lacking membranous ICAM-1

Blood, 2000
Mice deficient in intercellular adhesion molecule-1 (ICAM-1), lacking membranous ICAM-1, show a normal development but abnormalities of inflammatory and immune functions. Although the membrane-bound form of ICAM-1 is not detectable in the mutant strain, circulating ICAM-1 (cICAM) is present in serum from ICAM-1-deficient mice in similar amounts as in ...
N K, van Den Engel, E, Heidenthal, A, Vinke, H, Kolb, S, Martin   +4 more
openaire   +2 more sources

Role of the Adhesion Molecule ICAM-1 in Asthma

Journal of Asthma, 1995
Cells need to interact with one another for the inflammatory response to occur. The intercellular adhesion molecule-1 (ICAM-1), a member of the immunoglobulin supergene family, plays an important role in inflammation, and circulating ICAM-1 has been reported to be elevated in patients with some inflammatory disorders.
B B, Ceyhan, M, Sungur, T, Celikel, S S, Ozgün   +3 more
openaire   +3 more sources

ICAM-1-dependent fibroblast-lymphocyte adhesion: Discordance between surface expression and function of ICAM-1

Cellular Immunology, 1990
We have previously reported that stimulation of human fibroblasts (FB) with interferon-gamma (IFN-gamma) leads to their increased adhesiveness for resting peripheral blood T lymphocytes. With the use of blocking monoclonal antibodies, we determined that intercellular adhesion molecule-1 (ICAM-1) and its T cell ligand, lymphocyte function-associated ...
T H, Piela, J H, Korn
openaire   +2 more sources

Regulation of ICAM-1 Expression in Mouse Macrophages

Inflammation, 2000
In a mouse model of silica (SI) induced lung injury, SI exposure increases expression of intercellular adhesion molecule-1 (ICAM-1) on lung (alveolar/interstitial) macrophages and alveolar type II epithelial cells. To investigate the regulation of SI induced ICAM-1 expression on mouse macrophages, freshly isolated macrophages (alveolar, peritoneal) and
A K, Hubbard, C, Giardina
openaire   +2 more sources

Circulating ICAM-1 in Alcoholic Liver Cirrhosis

International Archives of Allergy and Immunology, 2009
The intercellular adhesion molecule 1 (ICAM-1) level in the serum of patients with alcoholic liver cirrhosis was measured using a sandwich enzyme-linked immunosorbent assay. Circulating ICAM-1 was significantly elevated in the sera of all 19 patients as compared with normal healthy subjects. There was no correlation with the Child grade of the disease,
Y, Mándi, I, Nagy
openaire   +2 more sources

Circulating ICAM-1 Is Increased in Septic Shock

American journal of respiratory and critical care medicine, 1995
Abstract Adhesion molecules play a critical role in the interaction of circulating neutrophils with vascular endothelium during inflammation. Increased quantities of soluble, circulating intercellular adhesion molecule-1 (cICAM-1) are present in various inflammatory conditions.
C N, Sessler, A C, Windsor, M, Schwartz, L, Watson, B J, Fisher, H J, Sugerman, A A, Fowler   +6 more
openaire   +2 more sources

ICAM-1 expression is upregulated in reflux nephropathy

Pediatric Surgery International, 2003
Reflux nephropathy (RN) is a major cause of end-stage renal failure in children and young adults. Intercellular adhesion molecule-1 (ICAM-1), a cell surface glycoprotein, has a role in the regulation of interaction among immune cells. It has been demonstrated that increased levels of tubular ICAM-1 correlate with an extent of tubular damage in diabetic
Kei, Unemoto, Boris, Chertin, Hideki, Shima, Xun, Bi, Masato, Sakai, Prem, Puri   +5 more
openaire   +2 more sources

Macrophage ICAM-1 functions as a regulator of phagocytosis in LPS induced endotoxemia

Inflammation Research, 2021
Hanhui Zhong, Xiaolei Liu, Jinghua Liu   +2 more
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