Comparative study on the rheological properties and tablettability of various APIs and their composites with titanate nanotubes [PDF]
, 2017 The present study aimed to investigate the processability of API-titanate nanotube composites into direct compressed tablets and therefore to reveal the benefits of the composite formation provided in tablet manufacturing.
Hódi Klára +4 more
core +1 more source
Glucocorticoids promote Von Hippel Lindau degradation and Hif-1α stabilization [PDF]
, 2017 Glucocorticoid (GC) and hypoxic transcriptional responses play a central role in tissue homeostasis and regulate the cellular response to stress and inflammation, highlighting the potential for cross-talk between these two signaling pathways.
Andrea Vettori +14 more
core +1 more source
Effect of troxerutin on serum glucose level and lactate dehydrogenase activity after exhaustive swimming in male rats [PDF]
, 2016 زمینه و هدف: ورزش وامانده ساز منجر به آسیب عضلانی و کاهش منابع انرژی نظیر گلوکز میشود. هدف مطالعه حاضر بررسی اثر مکمل تروگزروتین بر سطح سرمی گلوکز و فعالیت لاکتات دهیدروژناز متعاقب شنا وامانده ساز در موشهای صحرایی نر بود.
Hajizadeh, Mohammad Reza. +4 more
core
SiO2-CaO-P2O5 bioactive glasses: A promising curcuminoids delivery system [PDF]
, 2016 In this paper, we report the study of the loading and the release of curcuminoids by bioactive glasses (BG) and mesoporous bioactive glasses (MBG). Through a detailed spectroscopic study, it was possible to determine the amount and the type of molecules ...
Caselli, Monica +6 more
core +2 more sources
Stem Cells International, 2016 Bone tissue engineering technique is a promising strategy to repair large-volume bone defects. In this study, we developed a 3-dimensional construct by combining icariin (a small-molecule Chinese medicine), allogeneic bone marrow-derived mesenchymal stem
Tianlin Liu +4 more
doaj +1 more source
Using C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseases [PDF]
, 2015 Age-associated neurodegenerative disorders such as Alzheimer’s disease are a major public health challenge, due to the demographic increase in the proportion of older individuals in society.
A Gutierrez-Zepeda +141 more
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The α1‐adrenergic receptor is involved in hepcidin upregulation induced by adrenaline and norepinephrine via the STAT3 pathway [PDF]
, 2018 Elevated body iron stores are associated with hypertension progression, while hypertension is associated with elevated plasma catecholamine levels in patients. However, there is a gap in our understanding of the connection between catecholamines and iron
Bao, Yongping +9 more
core +1 more source
Icariin as a Treatment Proposal in Mammalian Reproduction
PharmaceuticalsIcariin (ICA), one of the main active components of Herba Epimedii, is a natural prenylated flavonol glycoside that possesses a wide range of pharmacological effects, including antioxidant, antiosteoporotic, anti-aging, neuroprotective, immunomodulatory, antitumor, and aphrodisiac effects, and prevents numerous health disorders, such as cardiovascular ...
Manuel Sánchez-Gutiérrez +4 more
openaire +3 more sources
Flavones induce neutrophil apoptosis by down-regulation of Mcl-1 via a proteasomal-dependent pathway [PDF]
, 2013 Neutrophil apoptosis and subsequent nonphlogistic clearance by surrounding phagocytes are key to the successful resolution of neutrophilic inflammation, with dysregulated apoptosis reported in multiple human inflammatory diseases.
Adriano G. Rossi +18 more
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Treatment with gelsolin reduces brain inflammation and apoptotic signaling in mice following thermal injury [PDF]
, 2011 Background Burn survivors develop long-term cognitive impairment with increased inflammation and apoptosis in the brain. Gelsolin, an actin-binding protein with capping and severing activities, plays a crucial role in the septic response.
Qing-Hong Zhang +7 more
core +2 more sources