Results 41 to 50 of about 4,688,154 (248)

Indoor radon in houses built on gravel and sand deposits in southern Finland [PDF]

Bulletin of the Geological Society of Finland, 1993
Studies by the Finnish Centre for Radiation and Nuclear Safety (STUK) have shown that, in Finland, indoor radon concentrations are almost twice as high in houses built on sand or gravel as in houses built on other soil types. The aim of this study was to
K.-L. Hutri, I. Mäkeläinen
doaj   +1 more source

Measuring currents, ice drift, and waves from space: the Sea surface KInematics Multiscale monitoring (SKIM) concept [PDF]

Ocean Science, 2018
We propose a satellite mission that uses a near-nadir Ka-band Doppler radar to measure surface currents, ice drift and ocean waves at spatial scales of 40 km and more, with snapshots at least every day for latitudes 75 to 82°, and every few days for ...
F. Ardhuin, Y. Aksenov, A. Benetazzo, L. Bertino, P. Brandt, E. Caubet, B. Chapron, F. Collard, S. Cravatte, J.-M. Delouis, F. Dias, G. Dibarboure, L. Gaultier, J. Johannessen, A. Korosov, G. Manucharyan, D. Menemenlis, M. Menendez, G. Monnier, A. Mouche, F. Nouguier, G. Nurser, P. Rampal, A. Reniers, E. Rodriguez, J. Stopa, C. Tison, C. Ubelmann, E. van Sebille, J. Xie   +29 more
doaj   +1 more source

Late Pleistocene glaciation and retreat of ice sheet on the shelf of the South Orkney Plateau, West Antarctica

Лëд и снег, 2021
The research aims to provide insight into reconstruction of the Late Pleistocene glaciations and ice retreat that followed the Last Glacial Maximum. The study is based on multi-channel seismic profiling and multibeam survey conducted on the shelf during ...
G. L. Leitchenkov, E. A. Bazhenova
doaj   +1 more source

Reconstructing ice dynamics in the central sector of the last British-Irish Ice Sheet [PDF]

, 2010
The central sector (NW England and Scottish borders) of the last British-Irish Ice Sheet exhibits a palimpsest glacial geological and geomorphological signature characteristic of multi-phase ice flow and ice-marginal fluctuations. Despite its influential
LIVINGSTONE, STEPHEN,JOHN, Livingstone, Stephen John   +1 more
core  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Ice Dynamics and Morphological Changes During Proglacial Lake Development at Exploradores Glacier, Patagonia

Frontiers in Earth Science, 2022
Proglacial lakes are ubiquitous features formed during deglaciarization and are currently increasing in number in Patagonia and elsewhere. Proglacial lakes can affect glacier dynamics, catchment hydrology and have the potential to cause glacial lake ...
Inigo Irarrazaval, Inigo Irarrazaval, Inigo Irarrazaval, Alejandro Dussaillant, Alejandro Dussaillant, Sebastián Vivero, Pablo Iribarren-Anacona, Gregoire Mariethoz   +7 more
doaj   +1 more source

Effects of an Explosive Polar Cyclone Crossing the Antarctic Marginal Ice Zone [PDF]

, 2019
Antarctic sea ice shows a large degree of regional variability, which is partly driven by severe weather events. Here we bring a new perspective on synoptic sea ice changes by presenting the first in situ observations of an explosive extratropical ...
Alberello, A, Bekker, Anriette,, Anriëtte Bekker, Jhon F. Mojica, Toffoli, Alessandro,, Luke Bennetts, Joubert, W, Mojica, JF, Onorato, M, Eayrs, Clare,, Bekker, A., MacHutchon, K, MacHutchon, K., Bennetts, L, Saunders, Clinton,, David Holland, Bennetts, Luke,, Sebastian Skatulla, Alberello, Alberto,, de Jong, E, Onorato, Miguel, Vichi, M, Bennetts, L., de Jong, E., Skatulla, Sebastian, de Jong, Ehlke,, Bennetts, Luke, Mojica, Jhon F.,, Eayrs, C, Toffoli, A, Holland, David, MacHutchon, Keith, Gabriele Messori, Warren Joubert, Saunders, C., Messori, Gabriele, Saunders, Clinton, Joubert, Warren,, Holland, David,, Mojica, J.F., Onorato, Miguel,, Alessandro Toffoli, Eayrs, Clare, Alberello, Alberto, Toffoli, Alessandro, BEKKER, A, Clinton Saunders, Messori, G, Keith MacHutchon, Vichi, Marcello,, MacHutchon, Keith,, Vichi, M., Vichi, Marcello, Joubert, Warren, de Jong, Ehlke, Onorato, M., Skatulla, Sebastian,, Ehlke de Jong, Bekker, Anriette, Skatulla, S., Holland, D., Joubert, W., Messori, Gabriele,, Saunders, C, Alberello, A., Alberto Alberello, Miguel Onorato, Toffoli, A., Messori, G., Mojica, Jhon F., Holland, D, Skatulla, S, Eayrs, C., Marcello Vichi, Clare Eayrs   +74 more
core   +1 more source