Results 61 to 70 of about 16,008 (226)

A High-Resolution Sea Ice Concentration Retrieval from Ice-WaterNet Using Sentinel-1 SAR Imagery in Fram Strait, Arctic

Remote Sensing
High spatial resolution sea ice concentration (SIC) is crucial for global climate and marine activity. However, retrieving high spatial resolution SIC from passive microwave sensors is challenging due to the trade-off between spatial resolution and ...
Tingting Zhu, Xiangbin Cui, Yu Zhang
doaj   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

Advanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole Parent, Xudong Fan, Ariella Shikanov, Matthew L. Kutys, Brendon M. Baker   +17 more
wiley   +1 more source

Micromorphology of modern tills in southwestern Spitsbergen – insights into depositional and post-depositional processes

Polish Polar Research, 2016
Textural properties and microstructures are commonly used properties in the analysis of Pleistocene and older glacial deposits. However, contemporary glacial deposits are seldom studied, particularly in the context of post-depositional changes.
Skolasińska Katarzyna, Rachlewicz Grzegorz, Szczuciński Witold   +2 more
doaj   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Observed bottom warming in the East Siberian Sea driven by the intensified vertical mixing [PDF]

Ocean Science
The East Siberian Sea (ESS) features the broadest continental shelf on Earth and contains nearly 80 % of the world's subsea permafrost. A persistently cold bottom layer, with temperatures at freezing point, inhibits the downward transport of heat, thus ...
X. Wang, X. Wang, X. Wang, L. Mu, X. Chen, X. Chen, X. Chen   +6 more
doaj   +1 more source

A 3D Human Bone and Bone Marrow‐on‐a‐Chip Model for In Vitro Bone Remodeling and Immune Cell Maintenance

Advanced Science, EarlyView.
This study presents a human Bone (and Bone Marrow)‐on‐a‐Chip model based on native human bone scaffolds and autologous cells. Dynamic perfusion and sequential cell seeding replicate the physiological bone remodeling process in vitro, enabling the long‐term culture of functional, mature bone marrow immune subpopulations.
Nina Stelzer, Melanie‐Jasmin Ort, Kristian Händler, Emely Bortel, Ioanna Maria Dimitriou, Martin Textor, Georg N. Duda, Janosch Schoon, Uwe Marx, Uwe Kornak, Annika Winter, Bernhard Hesse, Stefanie Donner, Sebastian Hardt, Oliver Klein, Simon Reinke, Malte Spielmann, Sven Geißler   +17 more
wiley   +1 more source

Fusing Ice Surface Temperature With the AI4Arctic Dataset for Improved Deep Learning-Based Sea Ice Mapping

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Arctic sea ice mapping is vital for supporting marine navigation, climate monitoring, and efforts by northern communities to adapt to variable ice conditions.
Lily de Loe, David A. Clausi, K. Andrea Scott   +2 more
doaj   +1 more source

Time‐Multiplexed Organic Electrochemical Transistor for Saliva‐Based Rapid Detection of Viral Proteins

Advanced Science, EarlyView.
A time‐multiplexed nanobody‐functionalized organic electrochemical transistor enables rapid and sensitive detection of three respiratory viral proteins from saliva. Sequentially addressed multi‐gate electrodes on a shared channel achieve around 1 fm detection within 15 min without sample preprocessing. Clinical validation demonstrates high specificity,
Tianrui Chang, Yuxiang Ren, Shofarul Wustoni, Atheer Alqatari, Adel Hama, Yazhou Wang, Long Chen, Jessica Parrado Agudelo, Luca Salvigni, Keying Guo, Ashraf Dada, Stefan T. Arold, Raik Grünberg, Sahika Inal   +13 more
wiley   +1 more source

Surface topography modelling and ice flow velocity mapping of Dalk Glacier, East Antarctica: application of UAV remote sensing [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences
The Antarctic Ice Sheet is the largest potential contributor to global sea level rise due to global climate warming, making it important to monitor changes in the marginal outlet glacier dynamics and surface topography. The unmanned aerial vehicle (UAV),
Z. Cao, Z. Cao, L. Tang, L. Tang, X. Yuan, X. Yuan, G. Qiao, G. Qiao   +7 more
doaj   +1 more source