Results 101 to 110 of about 18,238 (212)

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

The glacial geomorphology of the tweed valley and surrounding area, eastern British Isles. [PDF]

, 2009
This project focuses on reconstructing the glacial dynamics of the Tweed Valley and surrounding area in the Scottish Borders and northeast Northumberland from the glacial geomorphological record.
Staines, Kate E.H.
core  

Pholidota‐Inspired Electronic Skin Possessing Terahertz‐Wave Reflection–Absorption–Transmission Switchability

Advanced Science, EarlyView.
The pholidota‐inspired electronic skin is successfully constructed, originally realized four‐state reversible switching of terahertz‐wave reflection, absorption, transmission, and secondary reflection. In response to external demands, it issues deformation instructions, verifies the deformation state after the equipment executes the action, and thus ...
Shangjing Li, Jiangsong Hou, Yifeng Ruan, Jiang Du, Jun Qiu   +4 more
wiley   +1 more source

On the interpretation of ice-shelf flexure measurements

Journal of Glaciology, 2017
Tidal flexure in ice shelf grounding zones has been used extensively in the past to determine grounding line position and ice properties. Although the rheology of ice is viscoelastic at tidal loading frequencies, most modelling studies have assumed some ...
SEBASTIAN H. R. ROSIER, OLIVER J. MARSH, WOLFGANG RACK, G. HILMAR GUDMUNDSSON, CHRISTIAN T. WILD, MICHELLE RYAN   +5 more
doaj   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

A facet-based numerical model to retrieve ice sheet topography from Sentinel-3 altimetry [PDF]

The Cryosphere
In this study, we present a facet-based numerical model dedicated to ice sheet radar altimetry. The model simulates Sentinel-3 UnFocused-Synthetic Aperture Radar (UF-SAR) waveforms by calculating the backscattered radar signal over the 10 m facets of the
J. Aublanc, F. Boy, F. Borde, P. Féménias   +3 more
doaj   +1 more source

Breaking the Toughness‐Stretchability Trade‐Off in Hydrogels with Dynamic Hydrogen Bonding

Advanced Science, EarlyView.
A novel nanocomposite hydrogel architecture overcomes the inherent conflict between toughness and stretchability by integrating uniformly dispersed aminopropyl‐hybrid‐phyllosilicate nanosheets within a polyacrylamide matrix. This design leverages a dynamic hydrogen‐bonding network to facilitate efficient energy dissipation and self‐recovery.
Yining Gao, Yong Tao, Roland J.‐M. Pellenq, Fazhou Wang   +3 more
wiley   +1 more source

Synchronous terminus change of East Antarctic outlet glaciers linked to climatic forcing [PDF]

, 2013
In recent years there has been a growing trend of acceleration, thinning and retreat of ocean-terminating outlet glaciers in both the Greenland and West Antarctic Ice Sheets, resulting in an increasing contribution to sea level rise.
MILES, BERTIE
core  

Supraglacial forcing of subglacial drainage in the ablation zone of the Greenland ice sheet [PDF]

, 2011
Peer ...
Steven Palmer, Peter Nienow, Mair, Douglas, Mair, D., Wadham, J., S., Palmer, Douglas Mair, Ian Bartholomew, Sole, Andrew, Andrew Sole, Thomas Cowton, T., Cowton, Nienow, Peter, Jemma Wadham, Palmer, Steven, Wadham, JL, Cowton, Thomas, Bartholomew, Ian, Sole, A., Palmer, S., P., Nienow, Wadham, Jemma, Cowton, T., Bartholomew, I., A., Sole, Nienow, P.   +25 more
core   +1 more source

Improvements on the discretisation of boundary conditions to the momentum balance for glacial ice

Journal of Glaciology
The flow of glacial ice is typically approximated as a nonNewtonian viscous fluid, with the momentum balance described by (an approximation to) the Stokes equations, and the nonlinear rheology described by a flow law.
Constantijn J. Berends, Roderik S. W. van de Wal, Paul A. Zegeling   +2 more
doaj   +1 more source