Results 81 to 90 of about 2,560,774 (293)

Patient‐Derived 3D Heart‐On‐a‐Chip Model of Dilated Cardiomyopathy With Embedded Bead‐Based Mapping of Tissue Contractility

Advanced Healthcare Materials, EarlyView.
A heart‐on‐a‐chip model of dilated cardiomyopathy is developed from patient‐derived induced pluripotent stem cells. The model recapitulates key disease phenotypes and enables functional assessment through integrated bead‐based tracking and pillar deflection measurements.
Ali Mousavi, Ludovic Mouttet, Shihao Cui, Yasaman Hekmatnia, Mehran Mottahedi, Ida Derish, Naimeh Rafatian, Mark Aurousseau, Gregor Andelfinger, Renzo Cecere, Houman Savoji   +10 more
wiley   +1 more source

Exposure age and ice-sheet model constraints on Pliocene East Antarctic ice sheet dynamics [PDF]

Nature Communications, 2015
AbstractThe Late Pliocene epoch is a potential analogue for future climate in a warming world. Here we reconstruct Plio-Pleistocene East Antarctic Ice Sheet (EAIS) variability using cosmogenic nuclide exposure ages and model simulations to better understand ice sheet behaviour under such warm conditions.
Yamane, Masako, Yokoyama, Yusuke, Abe-Ouchi, Ayako, Obrochta, Stephen, Saito, Fuyuki, Moriwaki, Kiichi, Matsuzaki, Hiroyuki   +6 more
openaire   +2 more sources

Spatially extensive estimates of annual accumulation in the dry snow zone of the Greenland Ice Sheet determined from radar altimetry [PDF]

, 2010
We present estimates of accumulation rate along a 200 km transect ranging in elevation from 2750 to 3150 m in the dry snow zone on the western slope of the Greenland Ice Sheet.
Guo, Q., Helm, Veit, Helm, V., de la Peña, S., Mair, D., Shepherd, A., A. Shepherd, Huybrechts, P., Q. Guo, D. Wingham, Cullen, R., S. de la Peña, P. Huybrechts, Hanna, E., Huybrechts, Philippe, V. Helm, Wingham, D., D. Mair, E. Hanna, R. Cullen, Nienow, P., P. Nienow   +21 more
core   +2 more sources

Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong   +10 more
wiley   +1 more source

The potential of marine ice cliff instability for Amundsen Sea glaciers revisited

Annals of Glaciology
Marine ice cliff instability (MICI) is the hypothesis that self-sustained retreat of ice sheets can be initiated when sufficiently tall ice cliffs are exposed.
Sainan Sun, Gudmundur Hilmar Gudmundsson
doaj   +1 more source

Impact of ocean forcing on the Aurora Basin in the 21st and 22nd centuries

Annals of Glaciology, 2016
The grounded ice in the Totten and Dalton glaciers is an essential component of the buttressing for the marine-based Aurora basin, and hence their stability is important to the future rate of mass loss from East Antarctica. Totten and Vanderford glaciers
S. Sun, S. L. Cornford, D. E. Gwyther, R. M. Gladstone, B. K. Galton-Fenzi, L. Zhao, J. C. Moore   +6 more
doaj   +1 more source

Comparing a thermo-mechanical Weichselian Ice Sheet reconstruction to reconstructions based on the sea level equation: aspects of ice configurations and glacial isostatic adjustment [PDF]

Solid Earth, 2014
In this study we compare a recent reconstruction of the Weichselian Ice Sheet as simulated by the University of Maine ice sheet model (UMISM) to two reconstructions commonly used in glacial isostatic adjustment (GIA) modelling: ICE-5G and ANU (Australian
P. Schmidt, B. Lund, J-O. Näslund, J. Fastook   +3 more
doaj   +1 more source

A Three-Dimensional Model of the Antarctic Ice Sheet [PDF]

Annals of Glaciology, 1988
A preliminary version of a three-dimensional ice-sheet model for later use in climate models, but excluding ice shelves and basal sliding, is presented and applied to the Antarctic ice sheet. In the model, the three-dimensional fields of velocity and temperature are calculated in the coupled mode, and the temperature equation is integrated for 150 000 ...
openaire   +2 more sources

Engineered Nanoplatforms Targeting Activated Hepatic Stellate Cells for Liver Fibrosis Therapy via TGF‐β Axis Inhibition and Ferroptosis Induction

Advanced Healthcare Materials, EarlyView.
FeS‐VA@lanifibranor (FVL), an activated hepatic stellate cell (aHSC)‐targeted nanoplatform comprising vitamin A‐functionalized two‐dimensional iron sulfide nanosheets and lanifibranor, is engineered for precision therapy of liver fibrosis. FVL suppresses the TGF‐β signaling pathway by inhibiting SMAD2/3 phosphorylation and induces ferroptosis in aHSCs,
Yinuo Yang, Mengyao Mu, Ke Ren, Hui Liu, Pengju Ma, Yingqi Wang, Mengmeng Zhang, Xueli Xu, Wenzhe Li, Wenshuang Gao, Xiao Sun, Qiang Zhu   +11 more
wiley   +1 more source

The evolution of the Greenland Ice Sheet from the Last Glacial Maximum to present-day: An assessment using glaciological and Glacial Isostatic Adjustment modelling [PDF]

, 2009
In this thesis we constrain a three-dimensional thermomechanical model of Greenland ice sheet (GrIS) evolution from the Last Glacial Maximum (LGM, 21 ka BP) to the present-day using, primarily, observations of relative sea level (RSL) as well as field ...
SIMPSON, MATTHEW,JAMES,ROSS
core