Results 91 to 100 of about 3,902,696 (360)
The reversibility of sea ice loss in a state-of-the-art climate model [PDF]
, 2011 Rapid Arctic sea ice retreat has fueled speculation about the possibility of threshold (or ‘tipping point’) behavior and irreversible loss of the sea ice cover. We test sea ice reversibility within a state-of-the-art atmosphere–ocean global climate model
Armour, K. C. +4 more
core
Why Spin Ice Obeys the Ice Rules [PDF]
Physical Review Letters, 2005 The low temperature entropy of the the spin ice compounds, such as Ho$_2$Ti$_2$O$_7$ and Dy$_2$Ti$_2$O$_7$, is well described by the nearest-neighbor antiferromagnetic Ising model on the pyrochlore lattice, i.e.\ by the ``ice rules''. This is surprising since the dominant coupling between the spins is their long ranged dipole interaction.
Moessner, R. +2 more
openaire +4 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Diagnostic value of far-IR water ice features in T Tauri disks [PDF]
, 2018 This paper investigates how the far-IR water ice features can be used to infer properties of disks around T Tauri stars and the water ice thermal history.
Kamp, Inga +4 more
core +3 more sources
Arctic sea ice is an important temporal sink and means of transport for microplastic
Nature Communications, 2018 Microplastics (MP) are recognized as a growing environmental hazard and have been identified as far as the remote Polar Regions, with particularly high concentrations of microplastics in sea ice. Little is known regarding the horizontal variability of MP
I. Peeken +8 more
semanticscholar +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Hydrometeorological hazards on radiation contaminated territories of the East Ural region of Russia
Наука. Инновации. Технологии, 2022 In work possibility of influence of the dangerous hydrometeorological phenomena on character and scales of distribution of radioactive pollution of environment within radiation polluted areas is shown.
Victor Vladimirovich Razumov +1 more
doaj
A stratigraphic link across 1100 km of the Antarctic Ice Sheet between the Vostok ice-core site and Titan Dome (near South Pole) [PDF]
, 2000 Isochronous internal ice-sheet layering, measured from airborne 60 MHz radar, was traced between Lake Vostok and the Titan Ice Dome (100 km from South Pole Station), Antarctica. Three layers were selected between Ridge B and Titan Dome, and between Ridge
Bamber +11 more
core +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source