Results 121 to 130 of about 385,312 (256)

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

A strong Pacific Walker Circulation during the Little Ice Age. [PDF]

Sci Adv
Hess AV, Wang S, Ummenhofer CC, Rosenthal Y, Oppo DW.   +4 more
europepmc   +1 more source

Author Correction: Split westerlies over Europe in the early Little Ice Age. [PDF]

Nat Commun, 2022
Hu HM, Shen CC, Chiang JCH, Trouet V, Michel V, Tsai HC, Valensi P, Spötl C, Starnini E, Zunino M, Chien WY, Sung WH, Chien YT, Chang P, Korty R.   +14 more
europepmc   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

Genomic Diversity of Aurochs From a Mediterranean Ice-Age Refugium. [PDF]

Mol Ecol
Cubric-Curik V, Novosel D, Mijadžiković Z, Keršić I, Ferenčaković M, Radović S, Capitan A, Boussaha M, Stenderup J, Prohaska A, Willerslev E, Curik I, Miracle PT.   +12 more
europepmc   +1 more source

Global reorganization of deep-sea circulation and carbon storage after the last ice age. [PDF]

Sci Adv, 2022
Rafter PA, Gray WR, Hines SKV, Burke A, Costa KM, Gottschalk J, Hain MP, Rae JWB, Southon JR, Walczak MH, Yu J, Adkins JF, DeVries T.   +12 more
europepmc   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

Widespread tropical cyclone activity during the Late Paleozoic Ice Age. [PDF]

Nat Commun
Yan Q, Macarewich S, Jiang N, Kemp DB, Huan D, Poulsen CJ, Zhang J, Zhang Z, Wang H.   +8 more
europepmc   +1 more source

Colonial coral resilience by decreasing size: reaction to increased detrital influx during onset of the late Palaeozoic Ice Age. [PDF]

Proc Biol Sci, 2023
Yao L, Lin W, Aretz M, Bottjer DJ, Wang X.   +4 more
europepmc   +1 more source

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen   +7 more
wiley   +1 more source