Results 131 to 140 of about 372,439 (264)

The New Ice Age: Cold Applications in Pulmonology. [PDF]

Open Respir Arch
Solís García E, de Vega Sánchez B.
europepmc   +1 more source

Plankton response to global warming is characterized by non-uniform shifts in assemblage composition since the last ice age. [PDF]

Nat Ecol Evol, 2022
Strack T, Jonkers L, C Rillo M, Hillebrand H, Kucera M.   +4 more
europepmc   +1 more source

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

Maintenance of the great late Ediacaran ice age. [PDF]

Nat Commun
Liu P, Liu Y, Wang R, Li S, Sun Y, Wen B, Shen B.   +6 more
europepmc   +1 more source

Little Ice Age abruptly triggered by intrusion of Atlantic waters into the Nordic Seas. [PDF]

Sci Adv, 2021
Lapointe F, Bradley RS.
europepmc   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

The genomic history of Iberian horses since the last Ice Age. [PDF]

Nat Commun
Lira Garrido J, Tressières G, Chauvey L, Schiavinato S, Calvière-Tonasso L, Seguin-Orlando A, Southon J, Shapiro B, Bataille C, Birgel J, Wagner S, Khan N, Liu X, Rodanés JM, Picazo Millán JV, Giralt J, Alonso N, Aguilera I, Orsingher A, Trentacoste A, Payà X, Morán M, Iborra Eres MP, Albizuri S, Valenzuela Lamas S, Mestres Santandreu I, Duran Caixal M, Principal J, Farré Huguet J, Esteve X, Pedro Pasqual M, Sala N, Pablos A, Martín P, Vergès JM, Portero R, Arias P, Ontañón Peredo R, Detry C, Luís C, Cardoso JL, Maeir AM, Valente MJ, Grau E, Estall I Poles V, Alfonso Llorens J, Miguélez González A, Gardeisen A, Cupitò M, Tecchiati U, Bradley DG, Kolska Horwitz L, Rodríguez González E, Nieto Espinet A, Bover P, Ruiz Entrecanales R, Garcés Estallo I, Jiménez Fragoso J, Celestino S, Orlando L.   +59 more
europepmc   +1 more source

Glacial Ice Age Shapes Microbiome Composition in a Receding Southern European Glacier. [PDF]

Front Microbiol, 2021
Garcia-Lopez E, Moreno A, Bartolomé M, Leunda M, Sancho C, Cid C.   +5 more
europepmc   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

The earliest evidence of high-elevation ice age occupation in Australia. [PDF]

Nat Hum Behav
Way AM, Piper PJ, Chalker R, Wilkins D, Wilkins E, Watson Redpath L, Glass P, Carroll MR, Nutman E, Kononenko N, Spate M, Barrows TT, Wright D, Brennan W.   +13 more
europepmc   +1 more source