Results 131 to 140 of about 385,312 (256)

Accelerated mass loss of Himalayan glaciers since the Little Ice Age. [PDF]

Sci Rep, 2021
Lee E, Carrivick JL, Quincey DJ, Cook SJ, James WHM, Brown LE.   +5 more
europepmc   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

Protracted ocean circulation slowdown drove exceptional ice-sheet melting during ice age termination IV. [PDF]

Nat Commun
Hu HM, Marino G, Sánchez Goñi MF, Rohling E, Rodrigues T, Pérez-Mejías C, Ren Q, Jiang X, Michel V, Valensi P, Starnini E, Zunino M, Salonen JS, Hsieh CJ, Tan L, Chaigneau B, Chevalier M, Shen CC.   +17 more
europepmc   +1 more source

Long-term storage of gametes and gonadal tissues at room temperatures: the end of the ice age? [PDF]

J Assist Reprod Genet, 2022
Comizzoli P, Loi P, Patrizio P, Hubel A.
europepmc   +1 more source

Overcoming Artificial Structures in Resolution‐Enhanced Hi‐C Data by Signal Decomposition and Multi‐Scale Attention

Advanced Science, EarlyView.
Deep‐learning‐based signal enhancement is an effective way to recover high‐resolution details from a low‐resolution chromatin contact map. However, due to computational challenges, existing methods commonly divide up the contact map into small patches and create artificial discontinuities at patch boundaries.
Qinyao Li, Kelly Yichen Li, Chiara Nicoletti, Stephen Kwok‐Wing Tsui, Pier Lorenzo Puri, Qin Cao, Kevin Y. Yip   +6 more
wiley   +1 more source

Atrial fibrillation ablation: Is the Ice Age definitively over? [PDF]

Indian Pacing Electrophysiol J
Awada A, de Asmundis C, Chierchia GB.
europepmc   +1 more source

Glacial isostatic adjustment directed incision of the Channeled Scabland by Ice Age megafloods. [PDF]

Proc Natl Acad Sci U S A, 2022
Pico T, David SR, Larsen IJ, Mix AC, Lehnigk K, Lamb MP.   +5 more
europepmc   +1 more source

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

The New Ice Age: Cold Applications in Pulmonology. [PDF]

Open Respir Arch
Solís García E, de Vega Sánchez B.
europepmc   +1 more source

Plankton response to global warming is characterized by non-uniform shifts in assemblage composition since the last ice age. [PDF]

Nat Ecol Evol, 2022
Strack T, Jonkers L, C Rillo M, Hillebrand H, Kucera M.   +4 more
europepmc   +1 more source