Results 151 to 160 of about 372,439 (264)

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

Rapid rise in atmospheric CO₂ marked the end of the Late Palaeozoic Ice Age. [PDF]

Nat Geosci
Jurikova H, Garbelli C, Whiteford R, Reeves T, Laker GM, Liebetrau V, Gutjahr M, Eisenhauer A, Savickaite K, Leng MJ, Iurino DA, Viaretti M, Tomašových A, Zhang Y, Wang WQ, Shi GR, Shen SZ, Rae JWB, Angiolini L.   +18 more
europepmc   +1 more source

Northwestern Pacific tropical cyclone activity enhanced by increased Asian dust emissions during the Little Ice Age. [PDF]

Nat Commun, 2022
Yang Y, Piper DJW, Xu M, Gao J, Jia J, Normandeau A, Chu D, Zhou L, Wang YP, Gao S.   +9 more
europepmc   +1 more source

Protein Disulfide Isomerase Disassembles TDP‐43/G3BP1 Condensates and Antagonizes TDP‐43 Pathological Aggregates

Advanced Science, EarlyView.
Cytoplasmic aggregation of TDP‐43 is a common pathological feature in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and Alzheimer's disease with TDP‐43 pathology. This study reports that wild‐type PDI slows down phase separation of TDP‐43 through direct interaction with TDP‐43.
Jia‐Qi Liu, Hao Liu, Yu‐Xuan Sun, Yuying Li, Xiangyi Liu, Li‐Qiang Wang, Zhaofei Yang, Qi Fu, Xiaojiao Xu, Jie Chen, Yingshuang Zhang, Jun Zhou, Weidong Le, Mengchao Cui, Yi Liang   +14 more
wiley   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Recurrence rates of explosive volcanism in paleo-equatorial Pangaea, and implications for climate near the peak late Paleozoic ice age. [PDF]

Sci Rep
Pfeifer LS, Ramezani J, Van Den Driessche J, Pochat S, Soreghan MJ, Rustic G, Soreghan GS.   +6 more
europepmc   +1 more source

Author Correction: Northwestern Pacific tropical cyclone activity enhanced by increased Asian dust emissions during the Little Ice Age. [PDF]

Nat Commun, 2022
Yang Y, Piper DJW, Xu M, Gao J, Jia J, Normandeau A, Chu D, Zhou L, Wang YP, Gao S.   +9 more
europepmc   +1 more source

ZDHHC9‐Mediated Palmitoylation of ACSL4 Drives Ferroptosis in Diabetes Mellitus–Induced Erectile Dysfunction

Advanced Science, EarlyView.
ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo, Ming Xiao, Mengjun Huang, Dongzi Peng, Ruijiang Zeng, Ruilin Liu, Yuanqiao Zhao, Zhihan Ouyang, Yulong Hong, Zexian Ding, Zhuo Xing, Hao Su, Jinxiang Wang, Wenjun Mao, Xin Jin   +14 more
wiley   +1 more source

Out of the ice age: Preservation of cardiac allografts with a reusable 10 °C cooler. [PDF]

JTCVS Open
Trahanas JM, Harris T, Petrovic M, Dreher A, Pasrija C, DeVries SA, Bommareddi S, Lima B, Wang CC, Cortelli M, Fortier A, Tracy K, Simonds E, Keck CD, Scholl SR, Siddiqi H, Schlendorf K, Bacchetta M, Shah AS.   +18 more
europepmc   +1 more source

Recurrent transitions to Little Ice Age-like climatic regimes over the Holocene. [PDF]

Clim Dyn, 2021
Helama S, Stoffel M, Hall RJ, Jones PD, Arppe L, Matskovsky VV, Timonen M, Nöjd P, Mielikäinen K, Oinonen M.   +9 more
europepmc   +1 more source