Results 31 to 40 of about 385,312 (256)

Evaluation of ice volume in the Okhotsk Sea by the ice age characteristics for the period of 2001–2019

Известия ТИНРО, 2020
Age of ice in the Okhotsk Sea in 2001–2019 is determined by analysis of satellite data from passive and active microwave spectroradiometers. The areas with certain age composition are contoured with monthly discreteness.
V. M. Pishchalnik, I. G. Minervin, P. A. Truskov   +2 more
doaj   +1 more source

Where is the 1-million-year-old ice at Dome A? [PDF]

The Cryosphere, 2018
Ice fabric influences the rheology of ice, and hence the age–depth profile at ice core drilling sites. To investigate the age–depth profile to be expected of the ongoing deep ice coring at Kunlun station, Dome A, we use the depth-varying anisotropic ...
L. Zhao, L. Zhao, J. C. Moore, J. C. Moore, J. C. Moore, B. Sun, X. Tang, X. Guo   +7 more
doaj   +1 more source

Effects of nonlinear rheology, temperature and anisotropy on the relationship between age and depth at ice divides [PDF]

The Cryosphere, 2012
Ice flow in divide areas is strongly anisotropic. The evolution of ice fabric, from the onset of divide flow towards steady state with a fully developed fabric, has been shown to profoundly affect both the stratigraphy and surface topography of ice ...
C. Martín, G. H. Gudmundsson
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Relating the Age of Arctic Sea Ice to its Thickness, as Measured during NASA’s ICESat and IceBridge Campaigns

Remote Sensing, 2016
Recent satellite observations yield estimates of the distribution of sea ice thickness across the entire Arctic Ocean. While these sensors were only placed in operation within the last few years, information from other sensors may assist us with ...
Mark A. Tschudi, Julienne C. Stroeve, J. Scott Stewart   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Southernmost Eurasian Record of Reindeer (Rangifer) in MIS 8 at Galería (Atapuerca, Spain): Evidence of Progressive Southern Expansion of Glacial Fauna Across Climatic Cycles

Quaternary
During the Pleistocene, the successive ice ages prompted the southward expansion of the “Mammoth Steppe” ecosystem, a prevalent habitat that supported species adapted to cold environments such as the mammoth, woolly rhinoceros, and reindeer.
Jan van der Made, Ignacio A. Lazagabaster, Paula García-Medrano, Isabel Cáceres   +3 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Ice genesis and its long-term mass balance and dynamics in Scărişoara Ice Cave, Romania [PDF]

The Cryosphere, 2011
The paleoclimatic significance of the perennial ice deposit in Scărişoara Ice Cave has been remarked on since the early 20th century, but a lack of understanding of the processes involved in the genesis, age and long-term dynamics and volume fluctuations
A. Perşoiu, A. Pazdur
doaj   +1 more source