Results 51 to 60 of about 385,312 (256)

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

A climate data record of sea ice age using Lagrangian advection of a triangular mesh [PDF]

Earth System Science Data
We present LM-SIAge, a new Climate Data Record (CDR) of Arctic sea ice age spanning the period from 1991 through 2024. The dataset is based on a novel Lagrangian advection scheme applied to a triangular mesh, which conserves sea ice age fractions and ...
A. Korosov, A. Korosov, L. Edel, L. Edel, H. Regan, H. Regan, T. Lavergne, S. Aaboe, E. J. Down   +8 more
doaj   +1 more source

Investigating cold based summit glaciers through direct access to the glacier base: a case study constraining the maximum age of Chli Titlis glacier, Switzerland [PDF]

The Cryosphere, 2018
Cold glaciers at the highest locations of the European Alps have been investigated by drilling ice cores to retrieve their stratigraphic climate records.
P. Bohleber, P. Bohleber, H. Hoffmann, J. Kerch, J. Kerch, L. Sold, L. Sold, A. Fischer   +7 more
doaj   +1 more source

On the Origin of the Ice Ages

, 1984
Ice sheet dynamics provide a possible explanation for the 100 kyr power in climatic records. Some numerical experiments presented here show that even the transition from an essentially ice-free earth to a glacial can be produced by a northern hemisphere ice-sheet model, provided that a slow general cooling on the northern hemisphere continents is ...
openaire   +2 more sources

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Study on Bohai sea ice based on MODIS data

E3S Web of Conferences, 2018
Based on MODIS L1B data, we identify information of sea ice area, peripheral line and density, and also use Landsat data with higher resolution to verify the results obtained from MODIS data. Using pseudo color processing technology is more intuitive and
ye Zhou, Zhaopeng Fan
doaj   +1 more source

Estimation of the age of ice hummocks in the freezing seas

Лëд и снег, 2019
A method of estimating the ice ridge age proposed in the 1990s was analyzed and some disadvantages of this method were shown. Analysis of the ice thickness distribution in the ice ridges demonstrated that in many cases the average value of the thickness ...
E. U. Mironov, V. S. Porubaev
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

A combined approach of remote sensing and airborne electromagnetics to determine the volume of polynya sea ice in the Laptev Sea [PDF]

The Cryosphere, 2013
A combined interpretation of synthetic aperture radar (SAR) satellite images and helicopter electromagnetic (HEM) sea-ice thickness data has provided an estimate of sea-ice volume formed in Laptev Sea polynyas during the winter of 2007/08.
L. Rabenstein, T. Krumpen, S. Hendricks, C. Koeberle, C. Haas, J. A. Hoelemann   +5 more
doaj   +1 more source