Results 41 to 50 of about 385,312 (256)
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
Influence of anisotropy on velocity and age distribution at Scharffenbergbotnen blue ice area [PDF]
The Cryosphere, 2014 We use a full-Stokes thermo-mechanically coupled ice-flow model to study the dynamics of the glacier inside Scharffenbergbotnen valley, Dronning Maud Land, Antarctica.
T. Zwinger +3 more
doaj +1 more source
Ground-ice origin and age on Herschel Island (Qikiqtaruk), Yukon, Canada
Quaternary Science Advances, 2023 Glacial legacies preserved in permafrost such as buried glacial ice of the last ice age are of increasing concern in the Western Canadian Arctic. Permafrost collapse due to melting ground ice largely follows the margins of the maximum Laurentide Ice ...
Sebastian Wetterich +5 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
On Sea Ice/Water Discrimination by Airborne Weather Radar
IEEE Access, 2020 We consider a conceptual approach for the applicability of airborne weather radar for the sea ice/water discrimination and estimation of the sea ice age.
Alexey Nekrasov +6 more
doaj +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Preservation of the climatic signal in the old ice layers at Dome B area (Antarctica)
Лëд и снег, 2021 In this work we have presented the results of numerical modeling of the age and temperature distribution in ice layers at Dome B site (79,02° S, 93,69° E, altitude 3807 m a.s.l., ice thickness about 2.5 km), located 300 km to the west from Russian ...
A. A. Ekaykin +2 more
doaj +1 more source