Results 101 to 110 of about 7,279,413 (322)

Atmospheric Response to Kilometer‐Scale Changes in Sea Ice Concentration Within the Marginal Ice Zone

Geophysical Research Letters, 2018
Sea ice kilometer‐scale characteristics are not explicitly represented in weather and climate model systems. However, due to the large differences of the surface temperature between sea ice and ocean, sea ice‐free areas (leads, polynyas, etc.) can have a
Yurii Batrak, Malte Müller
semanticscholar   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Beryllium-7 and Lead-210 in the atmosphere and surface snow over the Greenland ice sheet in the summer of 1989 [PDF]

, 1990
The concentrations of 7Be and 210Pb were measured in surface air and fresh and aging snow samples from Summit (72°20′N, 38°45′W) and Dye 3 (65°10′N, 44°45′W) Greenland, during June and July 1989.
Dibb, Jack E.
core   +2 more sources

Internal Waves in the Arctic: Influence of Ice Concentration, Ice Roughness, and Surface Layer Stratification

Journal of Geophysical Research: Oceans, 2018
The Arctic ice cover influences the generation, propagation, and dissipation of internal waves, which in turn may affect vertical mixing in the ocean interior.
S. Cole, J. Toole, L. Rainville, Craig M. Lee   +3 more
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Research on Sea Ice and Local Ice Load Monitoring System for Polar Cargo Vessels

Journal of Marine Science and Engineering
Sea ice and the resulting loads are major safety concerns for vessels operating in ice-covered regions. This study presents a tailored sea ice and local ice load monitoring system specifically designed for polar cargo vessels.
Jinhui Jiang, Shuaikang He, Herong Jiang, Xiaodong Chen, Shunying Ji   +4 more
doaj   +1 more source

Block freeze-concentration of coffee extract: Effect of freezing and thawing stages on solute recovery and bioactive compounds [PDF]

, 2014
Coffee extract was freeze-concentrated using the total block technique. The effects of four parameters were evaluated: the initial coffee mass fraction (5 and 15% w/w), the cooling temperature ( 10 and 20 C), the heating temperature (20 and 40 C ...
Hernández Yáñez, Eduard, Moreno, F.L., Raventós Santamaria, Mercè, Ruiz, Y.   +3 more
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Assimilation of sea-ice concentration in a global climate model — physical and statistical aspects [PDF]

, 2012
We investigate the initialisation of Northern Hemisphere sea ice in the global climate model ECHAM5/MPI-OM by assimilating sea-ice concentration data. The analysis updates for concentration are given by Newtonian relaxation, and we discuss different ways
Jungclaus, J. H., Marotzke, J., Notz, D., Tietsche, S.   +3 more
core   +2 more sources