Results 91 to 100 of about 161,313 (308)

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Indirect ultraviolet photodesorption from CO:N2 binary ices - an efficient grain-gas process [PDF]

, 2013
UV ice photodesorption is an important non-thermal desorption pathway in many interstellar environments that has been invoked to explain observations of cold molecules in disks, clouds and cloud cores. Systematic laboratory studies of the photodesorption
Bertin, Mathieu, Fayolle, Edith C., Fillion, Jean-Hugues, Jeseck, Pascal, Linnartz, Harold, Michaut, Xavier, Philippe, Laurent, Poderoso, Hugo A. M., Romanzin, Claire, Öberg, Karin I.   +9 more
core   +5 more sources

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Discussion of the reliability of CO2, CH4 and N2O records from polar ice cores (scientific paper) [PDF]

, 2003
Air in polar ice has about the same composition as atmospheric air at the time of ice formation. This allows to determine the composition, especially the concentration of greenhouse gases, in the past.
Aoki ,Shuji, Fluckiger,Jacqueline, Monnin,Eric, Nakazawa ,Takakiyo, Stauffer,Bernhard   +4 more
core   +1 more source

Sedimentary processes at the base of a West Antarctic ice stream: Constraints from textural and compositional properties of subglacial debris [PDF]

, 1998
Samples of sediments from beneath Ice Stream B (at camp UpB), West Antarctica, provide the first opportunity to study the relationship between sediment properties and physical conditions in a sub-ice-stream environment.
Engelhardt, Hermann F., Kamb, Barclay, Scherer, Reed P., Tulaczyk, Slawek   +3 more
core   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Culturable bacteria isolated from seven high-altitude ice cores on the Tibetan Plateau

Journal of Glaciology, 2019
Microorganisms are the most abundant organisms on Earth, and microbial abundance records preserved in ice cores have been connected to records of environmental change.
YONGQIN LIU, JOHN C. PRISCU, TANDONG YAO, TRISTA J. VICK-MAJORS, ALEXANDER B. MICHAUD, LIANG SHENG   +5 more
doaj   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Consistency of the orbital chronologies derived for Vostok and EPICA DC ice cores based on the dependence of ice air content on local insolation

Лëд и снег
Total air content (TAC) is a multi­proxy property of polar ice, which is thought to contain evidence of past changes in local insolation, summer temperature, meteorological conditions, and the elevation of glaciersat the site of ice formation.
V. A. Khomyakova, N. A. Tebenkova, V. Ya. Lipenkov, D. Raynaud   +3 more
doaj   +1 more source